[Immunoelectrophorogram and serum levels of immunoglobulins G, A and M in automobile tire factory workers]. / Immunoelektroforogram oraz stezenia immunoglobulin G, A i M w surowicy krwi pracowników zakladow opon samochodowych.

Electrophoresis and immunoelectrophoresis of serum proteins and concentrations of IgG, IgA and IgM in serum were estimated in 87 rubber tire workers producing rubber mixtures (44 males) and tubes (25 males and 18 females). The total serum protein concentration, as compared with controls, was not changed, however the percentage of gamma globulins was elevated and that of albumins and alpha and beta globulins reduced. The immunoelectrophoretic distribution frequently showed a rise of acute phase proteins and immunoglobulins, most frequently those of IgG and IgA. Quantitative determinations showed a significant rise of serum IgG and IgA and in workers employed at the production of rubber mixtures also a fall of IgM concentrations, as compared to control groups.

Effect of organophosphoric pesticides on the behaviour of NBT-dye reduction and E rosette formation tests in human blood.

Investigations have been undertaken to determine the effect of occupational exposure to organophosphoric pesticides on the behaviour of NBT-dye reduction and spontaneous E rosette formation tests. A significant decrease of the values of the examined cellular parameters of human immunity and of the absolute lymphocyte count in peripheral blood was found in 31 workers, as compared to 30 controls. Moreover, the NBT-dye reduction decrease showed a positive linear correlation with a reduced acetylcholinesterase (AChE) activity. The exposure time showed a negative linear correlation of the phagocytic index of the NBT-dye reduction test. It is concluded that depressed NBT-dye reduction and diminished spontaneous E rosette formation may be regarded as a probable mode of the effect of organophosphoric chemicals on metabolic and membrane damage of human cells. A possible role of endogenous acetylcholine poisoning in the development of these pathologic conditions is also discussed.

[Serum levels of immunoglobulins and C 3 component of complement in persons occupationally exposed to chlorinated pesticides]. / Zawartosc immunoglobulin i skladnika C-3 dopelniacza w surowicy ludzi zawodowo narazonych na dzialanie pestycydów chlorowcopochodnych.

Serum concentrations of IgA, M, G and C-3 complement have been compared between 51 men occupationally exposed to chlorinated pesticides and 28 men of the control group. IgG has been found to be statistically significantly increased, whereas the concentration of IgM and C-3 complement--lower in the whole test group, as compared to the control group. These protein changes have been particularly strongly marked in the subgroup exposed to polycyclic chlorinated hydrocarbons. In the authors' opinion, the elevated IgG concentration in the occupationally exposed subgroup may result from immunostimulating effects of chlorinated pesticides, thus the decreased C-3 component of the complement in the serum in the test groups seems to be indicative of immune-complexes contribution to the pathogenesis of diseases resulting from the occupational exposure concerned. Furthermore, the authors suggest that the cyclic conformation of chlorinated pesticides may affect the pathomechanism of those diseases.

[Cytochemical analysis of selected dehydrogenases in peripheral blood leukocytes of workers exposed to polychlorinated pesticides]. / Badania cytochemiczne wybranych dehydrogenaz w leukocytach krwi obwodowej u pracowników narazonych na dzialanie pestycydów polichlorowych.

In 36 workers occupationally exposed to polychlorinated pesticides (Gammexane, DDT) and in a control group, cytochemical investigations of lactate and succinate dehydrogenases (LDH and SDH, respectively) in peripheral blood leukocytes were performed. In comparison with the control group, in workers exposed to pesticides, reduction of colour intensity in neutrophiles for SDH and in lymphocytes both for SDH and LDH was observed. In discussion, an attempt was made to interpret the obtained investigation results which seem to indicate disturbances in pyruvate metabolism in peripheral blood lymphocytes.