Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 5 de 5
Filtrar
Más filtros












Base de datos
Intervalo de año de publicación
2.
JBR-BTR ; 95(5): 297-9, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-23198368

RESUMEN

Hydatid disease (HD) is a unique parasitic infection that is endemic in many parts of the world. Although the disease primarly affects the liver, HD can be encountered almost anywhere in the body depending on its hematogenous dissemination. In this case report, we describe a 61-year-old man who presented with abdominal pain and urinary complaints. Imaging studies revealed a huge liver and pelvic region lesions that exhibited characteristic imaging findings for type 3 HD.The second lesion was interpreted as occurring due to dissemination from the liver HD. Due to the extensiveness of the disease, both surgery and percutaneous drainage of the lesions were excluded and the patient was put on albendazole treatment.


Asunto(s)
Dolor Abdominal/parasitología , Equinococosis Hepática/diagnóstico , Albendazol/uso terapéutico , Antihelmínticos/uso terapéutico , Diagnóstico Diferencial , Diagnóstico por Imagen , Equinococosis Hepática/tratamiento farmacológico , Humanos , Masculino , Persona de Mediana Edad
3.
Phys Rev Lett ; 100(17): 172501, 2008 May 02.
Artículo en Inglés | MEDLINE | ID: mdl-18518283

RESUMEN

Inclusive inelastic electron scattering off the deuteron under 180 degrees has been studied at the S-DALINAC close to the breakup threshold at momentum transfers q=0.27 fm;{-1} and 0.74 fm;{-1} with good energy resolution sufficient to map in detail the spin flip M1 response, which governs the starting reaction pn-->dgamma of big-bang nucleosynthesis over most of the relevant temperature region. Results from potential model calculations and (for q=0.27 fm;{-1}) from pionless nuclear effective field theory are in excellent agreement with the data.

4.
Biochem Mol Med ; 59(2): 174-81, 1996 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-8986641

RESUMEN

Recent studies have suggested that the insulin receptor tyrosine kinase inhibitor, membrane glycoprotein PC-1, may play a role in certain insulin resistant states. In the present study, we examined whether either insulin receptor function or PC-1 activity was altered during the development of insulin resistance that occurs with high fat feeding in normal rats. Over the course of 14 days of high fat feeding, both maximal and submaximal (physiological) insulin-stimulated skeletal muscle glucose uptake decreased gradually; after 14 days of high fat feeding, submaximal and maximal insulin-stimulated glucose uptake decreased by approximately 40 and approximately 50%, respectively. In contrast, in the same muscles (tibialis anterior) of these animals, neither insulin receptor content nor insulin-stimulated insulin receptor autophosphorylation was altered after 14 days of high fat feeding. PC-1 has both nucleotide pyrophosphatase (EC 3.6.1.9) and alkaline phosphodiesterase I (EC 3.1.4.1) enzyme activities. These enzyme activities showed no changes during the course of 14 days of high fat feeding. Individual data revealed that there was no significant correlation between insulin-stimulated glucose uptake and alkaline phosphodiesterase or nucleotide pyrophosphatase activity (P > 0.05). Together, these data indicate that neither defects in insulin receptor function nor elevated PC-1 activities are involved in the development of insulin resistance in rats with high fat feeding, and the insulin resistance induced with high fat feeding is likely due to postreceptor defects in skeletal muscle.


Asunto(s)
Grasas de la Dieta/administración & dosificación , Resistencia a la Insulina , Glicoproteínas de Membrana/metabolismo , Hidrolasas Diéster Fosfóricas , Pirofosfatasas , Receptor de Insulina/metabolismo , Animales , Insulina/fisiología , Masculino , Glicoproteínas de Membrana/antagonistas & inhibidores , Ratas , Ratas Wistar , Receptor de Insulina/antagonistas & inhibidores
5.
Invest Ophthalmol Vis Sci ; 36(7): 1433-40, 1995 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-7775121

RESUMEN

PURPOSE: The myotoxic drug doxorubicin can treat blepharospasm and hemifacial spasm permanently when injected directly into the eyelid of patients. One side effect of this treatment is the dose-related occurrence of injury to the skin overlying the injection site. The purpose of this study was to determine if injection of the immunosuppressive agent cyclosporin into rabbit eyelids before doxorubicin treatment could reduce the occurrence of injury to the overlying skin and to determine the effect of cyclosporin pretreatment on doxorubicin-induced muscle fiber loss. METHODS: Anesthetized rabbits received injections of varying doses of cyclosporin 20 minutes before injection of either 0.5, 1, or 2 mg doxorubicin. The rabbits were examined daily, and epithelial changes were recorded as to duration, time of onset, and healing. When the skin was completely healed, the animals were killed and eyelid tissue was prepared for morphometric determination of muscle fiber number. Acute inflammation was quantitatively assessed using an Evans blue assay. RESULTS: At specified doses, cyclosporin improved the doxorubicin chemomyectomy protocol in three ways. It delayed the onset of skin injury at the higher doses of doxorubicin, and it markedly decreased the duration of skin injury. At some doses, cyclosporin completely prevented the formation of epithelial defects. The combination, however, did not increase muscle loss compared to doxorubicin alone; in fact, it had a slightly myoprotective effect. A dose range for cyclosporin administration was determined that resulted in a quantitative and dose-dependent reduction in inflammation at the injection site. CONCLUSIONS: The injection of cyclosporin into the eyelids before doxorubicin treatment delayed the onset, reduced the duration, and limited the extent of development of eyelid skin injury. Perhaps by limiting cytokine release, cyclosporin decreased the inflammatory reaction compared to that seen with doxorubicin alone. This combination has the potential to improve patient acceptance of doxorubicin chemomyectomy for the treatment of blepharospasm and hemifacial spasm.


Asunto(s)
Ciclosporina/uso terapéutico , Doxorrubicina/efectos adversos , Enfermedades de los Párpados/prevención & control , Enfermedades de la Piel/prevención & control , Animales , Blefaroespasmo/tratamiento farmacológico , Ciclosporina/administración & dosificación , Doxorrubicina/uso terapéutico , Enfermedades de los Párpados/inducido químicamente , Párpados/efectos de los fármacos , Músculos Faciales/efectos de los fármacos , Inyecciones , Desnervación Muscular/métodos , Músculos Oculomotores/efectos de los fármacos , Conejos , Piel/efectos de los fármacos , Enfermedades de la Piel/inducido químicamente , Espasmo/tratamiento farmacológico
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...