Survey the Occurrence of Globocephalus urosubulatus (Nematoda: Ancylostomatidae) in Wild Boars (Sus scrofa) in the State of São Paulo, Brazil.

Although previous studies have characterized the helminth fauna of wild boars kept in captivity in Brazil, records on these helminths in free-ranging animals are still scarce. In view of this, we aimed in our work to investigate the occurrence and morphological and morphometric characteristics of gastrointestinal helminths in wild Sus scrofa from the northwest region of the State of São Paulo, Brazil. The digestive systems of 10 animals (5 males and 5 females of different ages) were used in this study. Each anatomical segment was washed and sieved under running water, and the helminths were separated and identified using light and scanning electron microscopy, according to their morphological characteristics. A total of 2750 (1152 males and 1598 females) nematode specimens were collected from the small intestine of these wild boars, and all of them presented the morphological characteristics of Globocephalus urosubulatus. However, one characteristic is of particular interest because it has not yet been reported in the literature: a marked asymmetry between the lobes and their respective rays of the copulatory bursa, with the left one being larger than the right one. In this research, we identified the presence of G. urosubulatus in all the examined free-ranging wild boars and reported for the first time in the literature the asymmetry in the copulatory bursa.

Nanostructured gadolinium(III) micelles: Synthesis, characterization, cytotoxic activities, and MRI applications in vivo.

Gadolinium-based contrast agents (GBCAs) are used in around 40 % of MRI procedures. Despite initial perceptions of minimal risk, their long-term use has emphasized the need to reduce toxicity and develop more efficient GBCAs with extended blood retention. Advancements in nanomaterials have led to improved GBCAs, enhancing MRI diagnostics. This study synthesizes and characterizes nanostructured gadolinium(III) micelles as superior MRI contrast agents. The complexes, [Gd(L)2], where L is a ligand of the N-alkyl-N-methylglucamine surfactant series (L8, L10 or L12, L10), form nanostructured micelles in aqueous solution. Gd(L8)2 and Gd(L10)2 relaxivities remained stable across concentrations. Compared to Gd-DTPA, Gd(III) micelles showed enhanced T1-weighted MRI contrast. Gd(L12)2 micelles exhibited cytotoxicity against B16F10 melanoma cells (IC50 42.5 ± 2.2 µM) and L292L929 fibroblasts (IC50 52.0 ± 2.5 µM), with a selectivity index of 1.2. In vivo application in mice brain T2-weighted images suggests nanostructured Gd(III) micelles are promising MRI contrast agents for targeting healthy organs or tumors.

Phylogenetic position inferred on SSU rDNA sequence gene and description of a new parasitic cnidarian (Endocnidozoa: Myxobolidae) infecting Markiana nigripinnis (Teleostei: Stevardiinae) from a small marginal lake floodplain, Brazil.

Herein, a detailed molecular phylogeny analysis was developed to determine the phylogenetic position of a new freshwater histozoic myxosporean cnidarian, Henneguya markiana sp. nov. from the world's largest tropical wetland area, Pantanal, Brazil. The new species is described using an integrative taxonomy approach including morphology, biological traits and molecular data. Phylogenetic analysis inferred by Maximum Likehood method showed the new Henneguya species in a well-supported clade of myxosporean gill parasites of South American characids fishes. In this same clade, the new Henneguya described appeared in a sub-clade clustering with H. lacustris and H. chydadea. Nevertheless, the sequences of the new species and H. lacustris and H. chydadea have a large genetic divergence of 10.4% (148 nucleotides-nt) and 10.5% (147 nt) respectively. To the best of our knowledge, this is the first report of a cnidarian myxosporean species parasitizing a fish from Stevardiinae from South America. In the light of the differences observed from the integrative taxonomy, we are confident that this isolate is a new species of Henneguya, increasing the knowledge of diversity of this enigmatic group of cnidarians.

New insights into a poorly known parasite, Dero lutzi (Oligochaeta: Naididae), associated with tree frogs of the genus Scinax: morphological evaluation and genotypic data.

The oligochaete Dero lutzi follows a life strategy that alternates between free-living periods in aquatic environments and endoparasitic phases. Most occurrences of D. lutzi in anurans are reported in species with arboreal habits, with studies limited to the recording of the oligochaete's presence in the host. Our study recovered specimens of D. lutzi from the tree frogs Scinax fuscovarius and Scinax. nasicus. We performed a morphological assessment of the parasite using light microscopy, for the first time, scanning electron microscopy. Molecular characterization of D. lutzi was carried out using the mitochondrial gene 16S rRNA and the nuclear gene 28S rRNA. Additionally, a phylogenetic tree was constructed to assess the species´position in relation to other group members. In our results, we confirmed the phenotypic morphological characteristics of the endoparasitic phase of D. lutzi. We also presented its phylogenetic position with other oligochaetes in the group, demonstrating the proximity between the endoparasite D. lutzi and the free-living oligochaete D. superterrenus.

"Cê anda igual bandido!": o que dizem os jovens sobre a construção midiática do criminoso? / "You look like a thug!": how do young people view the media's construction of the criminal? / « "T'as l'air d'un voyou! ¼: comment les jeunes perçoivent-ils la construction médiatique du criminel? / "¡Pareces un bandido!': ¿qué dicen los jóvenes sobre la construcción del criminal en los medios de comunicación?

Resumo A partir do cenário brasileiro, marcado por diferentes expressões da violência, são construídas práticas midiáticas que representam a juventude pauperizada de forma a criminalizar tal grupo. Este artigo apresenta uma discussão a respeito dos sentidos produzidos por jovens de 14 a 16 anos sobre as representações midiáticas expressas por setores da mídia hegemônica. Trata-se de uma pesquisa participante, delineada a partir da perspectiva do sociólogo Orlando Fals-Borda e da ideia de coautoria de Mikhail Bakhtin. A pesquisa foi realizada em uma cidade do estado de Minas Gerais, e foram construídos sete grupos de discussão, em que reportagens nas quais jovens são associados a episódios tidos como criminosos foram discutidas. Por meio dos diálogos construídos, foi possível identificar que o conteúdo midiático pode resultar em uma série de violências nas vidas desses jovens, que resistem através da busca por estratégias criativas, envolvendo a arte e mídias alternativas.

Abstract From a scenario marked by different expressions of violence emerge media practices set on criminalizing impoverished youth. This article examines the meanings produced by youth aged 14 to 16 years about the media representations broadcasted by hegemonic sectors. A participative research designed based on sociologist Orlando Fals-Borda's work and Mikhail Bakhtin's co-authorship was conducted with youth from the state of Minas Gerais. Seven discussion groups were created to debate the association between youth and criminal activity on the news. Analysis of the dialogues showed that media content can impart a series of violence in their lives. However, they resist through creative strategies involving art and alternative media.

Résumé A partir d'un scénario marqué par différentes expressions de la violence ressortent des pratiques médiatiques visant à criminaliser la jeunesse appauvrie. Cet article discute les significations produits par des jeunes de 14 à 16 ans à propos des représentations médiatiques formulées par les secteurs hégémoniques. Une recherche intervenante, esquissée d'après la perspective du sociologue Orlando Fals-Borda et du concept de cocréation de Mikhail Bakhtin, a été réalisée dans une ville de l'État du Minas Gerais. Sept groupes de discussion ont été créé pour débattre des reportages où des jeunes sont associés à des épisodes criminels. L'analyse des dialogues a montré que le contenu des médias peut mener à une série de violences dans leur vie. Pourtant, ils résistent grâce à des stratégies créatives faisant appel à l'art et aux médias alternatifs.

Resumen A partir del escenario brasileño, marcado por diferentes expresiones de violencia, se construyen prácticas mediáticas, para criminalizar a la juventude más pobre. Este artículo discute los sentidos producidos por jóvenes de 14 a 16 años respecto a las representaciones mediáticas, expressadas por sectores de los medios hegemónicos. Se trata de una investigação participante, diseñada a partir de la perspectiva del sociólogo Orlando Fals-Borda y la idea de coautoría de Mikhail Bakhtin. La investigación fue realizada en una ciudad del estado de Minas Gerais, mediante siete grupos de discusión, donde se analizaron las asociaciones que hacen de los jóvenes con episodios delictivos. A partir de los diálogos establecidos, se encontró que lo proyectado por los medios de comuncación puede resultar de considerables violencias en la vida de aquellos jóvenes, quienes se resisten a través de la búsqueda de estrategias creativas como el arte y medios alternativos.

Anquilobléfaro filiforme congênito / Ankyloblepharon filiforme adnatum

RESUMO O anquiloblefáro filiforme congênito é uma rara anomalia congênita, caracterizada por uma fusão palpebral, parcial ou completa, cuja incidência é de 4,4 por 100 mil recém-nascidos. Normalmente, o anquiloblefáro filiforme congênito constitui uma malformação solitária, de ocorrência esporádica, no entanto, pode estar associado a outras malformações. O pediatra possui papel imprescindível para observar as alterações clínicas do recém-nascido e dar orientação para o tratamento adequado. O objetivo deste estudo foi relatar o caso de recém-nascido de termo que teve diagnóstico precoce de anquiloblefáro filiforme congênito associado a outras malformações congênitas, tendo desfeito as aderências em procedimento cirúrgico oportuno, evitando-se a evolução para futuras complicações visuais do paciente.

ABSTRACT Ankyloblepharon filiforme adnatum is a rare congenital anomaly, characterized by partial or complete palpebral fusion, with an incidence of 4.4 per 100,000 newborns. Normally, ankyloblepharon filiforme adnatum constitutes a solitary malformation, with sporadic occurrence, however, it can be associated with other malformations. Pediatricians play an essential role in observing clinical changes in newborns and providing guidance on appropriate treatment. The this study aims to report the case of a full-term newborn who had an early diagnosis of ankyloblepharon filiforme adnatum associated with other congenital malformations.

Amblyomma sculptum ticks on a giant otter from the Brazilian Pantanal.

The giant otter (Pteronura brasiliensis) is a semiaquatic carnivore and a top predator in the trophic chain, considered a sentinel of freshwater ecosystems. Ticks are common ectoparasites of worldwide distribution and potential vectors of diseases. In this study, we report the ectoparasitism by ticks on a giant otter carcass found during monitoring activity at the Negro River, that holds a viable population of this endangered species in the Brazilian Pantanal. A total of three tick specimens were collected: two adults were identified as Amblyomma sculptum and a nymph as Amblyomma spp. There is a lack of information about the health of free-ranging giant otters and this report contributes to elucidate some of the host-parasite relationships, although much more research is needed to expand the knowledge about which kinds of pathogens are circulating in the species, especially among those transmitted by ticks.

A Combination of Ex Vivo and In Vivo Strategies for Evaluating How Much New Oral Anticoagulants Exacerbate Experimental Intracerebral Bleeding.

Background Intracerebral hemorrhage is the most serious complication of anticoagulant therapy but the effects of different types of oral anticoagulants on the expansion of these hemorrhages are still unclear. Clinical studies have revealed controversial results; more robust and long-term clinical evaluations are necessary to define their outcomes. An alternative is to test the effect of these drugs in experimental models of intracerebral bleeding induced in animals. Aims To test new oral anticoagulants (dabigatran etexilate, rivaroxaban, and apixaban) in an experimental model of intracerebral hemorrhage induced by collagenase injection into the brain striatum of rats. Warfarin was used for comparison. Methods Ex vivo anticoagulant assays and an experimental model of venous thrombosis were employed to determine the doses and periods of time required for the anticoagulants to achieve their maximum effects. Subsequently, volumes of brain hematoma were evaluated after administration of the anticoagulants, using these same parameters. Volumes of brain hematoma were evaluated by magnetic resonance imaging, H&E (hematoxylin and eosin) staining, and Evans blue extravasation. Neuromotor function was assessed by the elevated body swing test. Results and Conclusions The new oral anticoagulants did not increase intracranial bleeding compared with control animals, while warfarin markedly favored expansion of the hematomas, as revealed by magnetic resonance imaging and H&E staining. Dabigatran etexilate caused a modest but statistically significant increase in Evans blue extravasation. We did not observe significant differences in elevated body swing tests among the experimental groups. The new oral anticoagulants may provide a better control over a brain hemorrhage than warfarin.

Itinerários terapêuticos de mulheres em situação de rua: as múltiplas faces do cuidado / Itinerarios terapéuticos de mujeres en situación de calle: las múltiples caras del cuidado / Therapeutic itineraries of homeless women: the multiple faces of care

Resumo O presente trabalho teve como objetivo refletir sobre a relação entre os itinerários terapêuticos de mulheres em situação de rua e os serviços de saúde e da assistência social. Utilizou-se como estratégia metodológica a etnografia multilocal, e como técnicas de construção dos dados, a observação participante e o diário de campo. Duas mulheres em situação de rua foram acompanhadas em suas trajetórias de busca por cuidados em saúde, e as observações foram feitas também na Casa de Passagem para mulheres, no Fórum da População em Situação de Rua, e junto ao Consultório na Rua. Os resultados apontam que os itinerários terapêuticos das mulheres se referem, principalmente, às possibilidades de produção de vida e apontam como os sentidos sobre o que é necessário precisam ser abarcados e compreendidos pelas redes de cuidado.

Resumen Este estudio tuvo como objetivo reflexionar sobre la relación entre los itinerarios terapéuticos de mujeres en situación de calle y los servicios de salud y de asistencia social. Fue utilizada como estrategia metodológica la etnografía multilocal, y como técnicas de recolección de datos, la observación participante y el diario de campo. Se acompaño a dos mujeres en situación de calle en sus trayectorias de búsqueda de atención en salud, y las observaciones fueron realizadas en la Casa de Passagem (Centro de Rehabilitación) para mujeres, en el Fórum da População em Situação de Rua (Foro de la Población en Situación de Calle), y en el Consultório na Rua (Oficina en la Calle). Los resultados apuntan que los itinerarios terapéuticos de las mujeres se refieren, principalmente, a las posibilidades de producción de vida y apuntan cómo los significados sobre lo necesario deben ser abarcados y comprendidos por las redes de atención en salud.

Abstract The aim of this study was to reflect on the relationship between the therapeutic itineraries of homeless women and health and social assistance services. Multilocal ethnography was used as a methodological strategy, and participant observation and field diary were used as data construction techniques. Two homeless women were accompanied in their search for health care, and observations were also made at the Casa de Passagem (Halfway House) for women, at the Fórum da População em Situação de Rua (Homeless Population Forum), and at the Consultório na Rua (Office on the street). The results point out that the women's therapeutic itineraries refer, mainly, to the possibilities of life production and point out how the meanings of what is necessary must be embraced and understood by the care networks.

Pobreza, subalternidade e rupturas: problematizações acerca dos sujeitos na política de assistência social / Poverty, subalternity and ruptures: problems regarding subjects in social assistance policy / Pobreza, subalternidad y rupturas: problematizaciones acerca de los sujetos en la política de asistencia social

O presente trabalho visa analisar como os sujeitos destinatários da política de assistência social compreendem e se relacionam com as ações e programas sociais desenvolvidos. Recorremos, portanto, ao uso da entrevista semiestruturada, que contou com dez participantes, bem como do diário de campo proveniente do período de acompanhamento das atividades desenvolvidas em um Centro de Referência em Assistência Social (CRAS). O material construído e analisado abarca as seguintes categorias: (a) Assistência social: direito ou benesse? (b) Assistência social e (vs) trabalho: da (re) negação à busca por direitos; (c) Dilemas postos na condição de "assistido": tutela, subalternidade e rupturas. Os resultados sugerem, assim, que a perspectiva histórica da subalternidade presente no campo da assistência social, a qual vem sendo reforçada pela agenda neoliberal, impõe desafios para o avanço nas condições materiais e subjetivas de vida dos sujeitos "assistidos", podendo, por vezes, favorecer processos psicossociais de resignação e comprometer mecanismos de participação e controle social.

The present work aims to analyze how the "users" of the social assistance policy understand and relate to the social actions and programs. We resorted, therefore, to the use of semi-structured interviews, which included ten participants, as well as a field diary from the period of monitoring the activities developed in a Reference Center for Social Assistance (CRAS). The material built and analyzed covers the following categories: (a) Social assistance: right or benefit? (b) Social assistance and (vs) work: from (re)denial to the search for rights; (c) Dilemmas placed in the condition of "assisted": guardianship, subalternity and ruptures. The results suggest, therefore, that the historical perspective of subalternity present in the field of social assistance, which has been reinforced by the neoliberal agenda, poses challenges for the advancement of the material and subjective conditions of life of the "assisted" subjects, and may, sometimes favor psychosocial processes of resignation and compromise mechanisms of participation and social control.

El presente trabajo tiene como objetivo analizar cómo las personas atendidas por la política de asistencia social entienden y se relacionan con las acciones y programas sociales desarrollados. Por lo tanto, utilizamos la entrevista semiestructurada, que incluyó a diez participantes, así como el diario de campo del período de seguimiento de las actividades desarrolladas en un Centro de Referencia en Asistencia Social (CRAS). El material construido y analizado incluye las siguientes categorías: (a) Asistencia social: ¿derecho o ayuda? (b) Asistencia social y (vs) trabajo: de la (re)negación a la búsqueda de derechos; (c) Dilemas planteados en la condición de "asistidos": tutela, subalternidad y rupturas. Los resultados sugieren, por lo tanto, que la perspectiva histórica de subalternidad presente en el campo de la asistencia social, que ha sido reforzada por la perspectiva neoliberal, impone desafíos para el avance en las condiciones materiales y subjetivas de vida de las personas "asistidas", pudiendo contribuir, algunas veces, con los procesos psicosociales de resignación y comprometer los mecanismos de participación y control social.

First report of myiasis caused by Cochliomyia hominivorax in free-ranging giant otter (Pteronura brasiliensis).

Giant otters are territorial semi-aquatic mammals. It is common to find several individuals exhibiting wounds and scars due to intraspecific conflicts. Myiasis is a parasitic infestation on living tissues of vertebrates caused by dipterous larvae, that usually develops in freshly open wounds and can seriously threaten the host's health. Ectoparasites seem to be rare among giant otters and myiasis had not been recorded in this species until now. Here, is presented one record of myiasis in a free-ranging giant otter found dead in the Pantanal, Brazil. An ulcerative lesion was found in the frontoparietal region, from which 22 larvae were recovered and identified as Cochliomyia hominivorax. The low occurrence of ectoparasites in giant otters might reflect their semi-aquatic habits and their grooming behavior, which makes it difficult for parasites to remain on the skin. The injured otter probably got the larvae after an intraspecific fight. Agonistic encounters between groups of giant otters have been reported before and these fights can result in serious wounds or even death. It was hypothesized that the myiasis caused by C. hominivorax deteriorated the health of the infested giant otter, which prevented recovery and accelerated its death.

As artimanhas da titularidade feminina: análise a partir das histórias de vida das mulheres do Bolsa Família / The tricks of female ownership: analysis from the life stories of "Bolsa Família" women (Brazilian Family Assistance Program women) / Las artimañas de la titularidad femenina: análisis a partir de las historias de vida de las mujeres de "Bolsa Família" (Programa de Asistencia Económica Familiar)

Este artigo objetivou evidenciar as concepções das mulheres do Bolsa Família acerca da titularidade feminina. Para tanto, quatro entrevistas semiestruturadas, baseadas no método da história de vida foram realizadas, cuja técnica de análise dos dados empregada foi do tipo temática. Dentre os resultados, identificamos que para as mulheres, a titularidade é compreendida como um avanço político importante por contribuir nas tomadas de decisão no espaço doméstico. Elas também não identificaram problemas no tocante ao cumprimento das condicionalidades, o que tencionamos tratar de ações compreendidas como da ordem "materna". Ademais, elas pouco se compreenderam enquanto sujeitos ativos do processo de transformação da realidade, o que nos exige repensar a nossa prática profissional. Por fim, conclui-se que as artimanhas da titularidade feminina tendem a retroalimentar a fusão entre a ideologia patriarcal e o neoliberalismo, na medida em que o Estado se ausenta e transfere para as titulares-mães responsabilidades na erradicação da pobreza.

This article aimed to highlight the conceptions of Bolsa Família women (Family Assistance Program women) about female ownership. Therefore, four semi-structured interviews were carried out, based on the life history method, which data analysis technique was of the thematic type. Among the results, we identified that for women, ownership is understood as an important political advance for contributing to decision-making in the domestic space. They also did not identify problems regarding the fulfillment of conditionalities, which we intend to deal with actions understood as of the "maternal" order. Furthermore, they were poorly comprehended as active subjects in the process of transforming reality, which requires us to rethink our professional practice. Finally, it is concluded that the tricks of female ownership tend to feed back the fusion between patriarchal ideology and neoliberalism, insofar as the State is absent and transfers responsibilities in the eradication of poverty to the owner-mothers.

Este artículo tuvo como objetivo resaltar las concepciones de las mujeres de Bolsa Família (Programa de Asistencia Económica Familiar) sobre la titularidad femenina. Para ello, se realizaron cuatro entrevistas semiestructuradas, basadas en el método de historia de vida, cuya técnica de análisis de datos fue de tipo temático. Entre los resultados, identificamos que para las mujeres la titularidad es entendida como un avance político importante para contribuir a la toma de decisiones en el espacio doméstico. Tampoco identificaron problemas en cuanto al cumplimiento de condicionalidades, que pretendemos atender con acciones entendidas como de orden "materno". Además, fueron poco comprendidas como sujetos activos en el proceso de transformación de la realidad, lo que nos obliga a repensar nuestra práctica profesional. Finalmente, se concluye que las artimañas de la titularidad femenina tienden a retroalimentar la fusión entre la ideología patriarcal y el neoliberalismo, en la medida en que el Estado está ausente y transfiere las responsabilidades de la erradicación de pobreza a las madres-titulares.

Raillietia auris (Mesostigmata: Raillietiidae) in cattle in the state of Mato Grosso do Sul, Brazil.

Parasitic otitis in cattle, caused by mites, has been reported from several continents. The present study aimed to determine the distribution, prevalence, intensity, mean intensity, and range of the agent in cattle in the state of Mato Grosso do Sul, Brazil. The samples were designed at random, with an acceptable margin of error of 3% and a confidence interval of 99%. A total of 449 animals were sampled immediately after slaughter from 34 different municipalities in the state using the technique of flushing both ear canals. Only Raillietia auris (Leidy, 1872) were found, with a prevalence of 98.6%, mean intensity of 53.78 mites/animal, and a range of 1-323. Impressively, the prevalence found was identical to another survey carried out 39 years ago in the same region. Details about the parasite intensity in different age categories of the animals are presented. The study demonstrates that the prevalence and intensity of infestation by Raillietia auris are high, and in older cattle are higher than young ones.

Hyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage.

Aim: Intracerebral hemorrhage (ICH) has limited therapeutic options. We have shown that an intravenous injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSC) 24 h after an ICH in rats reduced the residual hematoma volume after a moderate hemorrhage but was inefficient in severe ICH. Here, we investigated whether a treatment in the hyperacute phase would be more effective in severe ICH. Materials & methods: Wistar rats were randomly selected to receive an intravenous injection of hUC-MSC or the vehicle 1 h after a severe ICH. Results: The hyperacute treatment with hUC-MSC did not affect the 22-day survival rate, the motor function or the residual hematoma volume. Conclusion: These results indicate the need for optimization of hUC-MSC-based therapies for severe ICH.

Mídia, criminalização da juventude e adesão subjetiva à barbárie / Media, youth criminalization and subjective adherence to barbarism / Media, criminalizacion de la juventude y la adhesion subjetiva a la barbárie

A partir das representações midiáticas, são apresentadas cotidianamente cenas marcadas pela violência urbana. Protagonizando as reportagens, a juventude oriunda de classes subalternas é compreendida como responsável por essa realidade. Enquanto isso, a população clama por medidas punitivas. A presente revisão narrativa propõe uma discussão sobre a possível relação entre a mídia hegemônica, as representações sobre violência urbana e a criminalização dessa faceta da juventude, sustentando práticas sociais que compõem a adesão subjetiva à barbárie. Primeiramente, são apresentados o debate a respeito das mídias e o cenário brasileiro. Em seguida, é discutida a imagem do "jovem bandido" através do olhar da criminologia crítica. Por fim, apresenta-se a discussão sobre a construção de consensos a partir da mídia brasileira. Através de estratégias de desumanização dos sujeitos, as práticas midiáticas hegemônicas contribuem para que estejamos aderidos à barbárie que violenta, principalmente, os jovens inseridos no âmbito das periferias brasileiras. (AU)

From the media representations, scenes marked by urban violence are daily presented. Protagonising the news, youth from lower classes are understood as responsible for this reality. Meanwhile, the population claims for punitivemeasures. This narrative review proposes a discussion about the possible relationship between hegemonic media, representations of urban violence and the criminalization of this facet of youth, supporting social practices that composes the subjective adherence to barbarism. First, the debate about the media and the brazilian scenario is presented. Then, the image of the "young bandit" is discussed through the view of critical criminology. Finally, the discussion on the construction of consensus from the brazilian media is presented. Through strategies of dehumanization of subjects, hegemonic media practices contribute to adherence to the barbarism that mainly violates young people inserted in the brazilian peripheries. (AU)

Desde las representaciones mediáticas, se visibilizaescenas cotidianas marcadas por la violencia urbana, apareciendo en los reportajes que jóvenes en condiciones de pobreza extrema son responsables de esa realidad y la población solicitando para ellos medidas punitivas. La presente revisión narrativa discute la posible relación entre: Medios hegemónicos, representaciones sociales alrededor de la violencia urbana y la criminalización de esa faceta de la juventud, las cuales respaldan prácticas de "adhesión subjetiva a la barbarie". En primer lugar es presentado el debate sobre medios y escenarios Brasileños; posteriormente, se muestra la imagen del "joven bandido" desde la postura de la criminología crítica; en última instancia, se discute sobre la construcción de consensos a partir de los medios Brasileños. Mediante la estrategia deshumanizante de los sujetos, las prácticas mediáticas hegemónicas contribuyen a la adhesión colectiva hacia la barbarie, perjudicando de manera violenta especialmente a jóvenes inmersos en las periferias Brasileña. (AU)

Identification of NID1 as a novel candidate susceptibility gene for familial non-medullary thyroid carcinoma using whole-exome sequencing.

The genetics underlying non-syndromic familial non-medullary thyroid carcinoma (FNMTC) is still poorly understood. To identify susceptibility genes for FNMTC, we performed whole-exome sequencing (WES) in a Brazilian family affected by papillary thyroid carcinoma (PTC) in three consecutive generations. WES was performed in four affected and two unaffected family members. Manual inspection in over 100 previously reported susceptibility genes for FNMTC showed that no variants in known genes co-segregated with disease phenotype in this family. Novel candidate genes were investigated using PhenoDB and filtered using Genome Aggregation (gnomAD) and Online Archive of Brazilian Mutations (ABraOM) population databases. The missense variant p.Ile657Met in the NID1 gene was the only variant that co-segregated with the disease, while absent in unaffected family members and controls. The allele frequency for this variant was <0.0001 in the gnomAD and ABbraOM databases. In silico analysis predicted the variant to be deleterious or likely damaging to the protein function. Somatic mutations in NID1 gene were found in nearly 500 cases of different cancer subtypes in the intOGen platform. Immunohistochemistry analysis showed NID1 expression in PTC cells, while it was absent in normal thyroid tissue. Our findings were corroborated using data from the TCGA cohort. Moreover, higher expression of NID1 was associated with higher likelihood of relapse after treatment and N1b disease in PTCs from the TCGA cohort. Although replication studies are needed to better understand the role of this variant in the FNMTC susceptibility, the NID1 variant (c.1971T>G) identified in this study fulfills several criteria that suggest it as a new FNMTC predisposing gene.

Gênero, pobreza e saúde: revisão sistemática sobre a saúde de mulheres em situação de rua / Gender, poverty and Health: systematic review on the health of homeless women

As mulheres em situação de rua, parte de um fenômeno que se constitui como uma problemática global e inerente ao modo de produção capitalista (MPC), estão submetidas a uma série de opressões e desigualdades, especialmente alarmantes no que se refere a sua saúde. O objetivo do presente trabalho foi realizar uma revisão sistemática de literatura a fim de conhecer o que tem sido pesquisado sobre a saúde desse grupo de mulheres no contexto nacional e internacional, considerando-se as especificidades relacionadas à condição de gênero. Foram realizadas buscas nas bases de dados Lilacs, Redalyc, Psychinfo, SciELO, ERIC e no Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/Brasil). A partir dos descritores homeless women, health, health care, health care policy e therapeutic itineraries, chegou-se a uma amostra final composta por 21 artigos, cuja análise foi expressa em três categorias: violência, pobreza e viver nas ruas: implicações para a saúde das mulheres; maternidade, trabalho e saúde: ambivalência sentida nos corpos; e acesso aos serviços de saúde e assistência social. Os achados evidenciam a interseção entre condição de gênero, situação de rua e saúde, apontando o caráter transcultural do fenômeno, e a necessidade de se investir em mais investigações na área.

Homeless women, part of a phenomenon that constitutes as a global problem and inherent to the capitalist mode of production (CMP), are subject to a series of oppression and inequalities that are especially alarming with regard to their health. This study aimed to understand what has been researched about this group of woman, in the nacional and internacional context, from a systematic literature review, and taking into account gender particularities. The following databases were consulted: Lilacs, Redalyc, SciELO, ERIC, and the website of Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/Brazil). The key words selected were homeless women, health, health care, health care policy and therapeutic itineraries, through which a final sample of 21 articles were found, having their analysis expressed in three categories: Violence, poverty and living on the streets: implications for women's health; motherhood, work and health: ambivalence felt in the bodies; access to health and social assistance services. The findings show the intersection between gender, the life in the streets and health, highlighting the cross-cultural character of the phenomenon, and the need to invest in further research in the area.

Intersetorialidade nas Políticas Públicas sobre Drogas: Relações entre Saúde e Assistência Social / Intersectoriality in Drug Public Policies: Relations between Healthcare and Welfare Resources / Intersectorialidad en las Políticas Públicas sobre Drogas: Relaciones entre Salud y Asistencia Social

As políticas, programas e serviços no campo de álcool e outras drogas devem ocorrer a partir dos princípios da integralidade e intersetorialidade, assegurando a participação social. Nessa direção, o objetivo do presente trabalho foi compreender como se dão as relações entre as redes de saúde e assistência social, com vistas a assegurar ações orientadas pela intersetorialidade no cuidado aos usuários de substâncias psicoativas em um município de Minas Gerais, Brasil. Foram realizadas entrevistas individuais com os gestores destes setores, além de um grupo focal com profissionais que atuam no Sistema Único de Saúde e Sistema Único de Assistência Social. Os resultados foram organizados nos seguintes eixos de análise: (1) (des)articulação da rede: impasse para o trabalho intersetorial; (2) redes em movimento: práticas profissionais no cotidiano de cuidado; (3) tensões entre diferentes atores na rede de cuidado em álcool e drogas. Tais resultados expressam a realidade de grande parte dos municípios brasileiros, em que as ações no âmbito das políticas públicas ocorrem de maneira desarticulada, sendo ainda o princípio da intersetorialidade um horizonte a ser construído. (AU)

Policies, programs and services in the field of alcohol and other drugs (AOD) must be based upon the principles of integrality and intersectoriality, ensuring social participation. These aspects might guide Brazilian psychosocial care network. In this direction, the present study aimed to understand the relationship between health networks and social assistance regarding the health care of psychoactive substances users in a city at Minas Gerais, Brazil. Individual interviews were conducted with the managers of these sectors, as well as a focus group with professionals working in Brazilian National Systems of Healthcare and Social Services. The results were organized in the following axes of analysis: (1) (dis)articulation of the network: challenge for intersectoral work; (2) networks in movement: professional practices in daily care; (3) tensions between different actors in the alcohol and other drugs (AOD) network. These results express the reality of most Brazilian municipalities, in which public policies occur in a disjointed way, and the principle of intersectoriality is a horizon to be constructed. (AU)

Las políticas, programas y servicios en el campo de alcohol y otras drogas deben ocurrir a partir de los principios de la integralidad e intersectorialidad, asegurando la participación social. En esta dirección, el objetivo del presente trabajo fue comprender la relación entre las redes de salud y asistencia social en cuanto a la atención a los usuarios de sustancias psicoactivas en un municipio de Minas Gerais, Brasil. Se realizaron entrevistas individuales con los gestores de estos sectores, además de un grupo focal con profesionales que actúan en el Sistema Único de Salud y Sistema Único de Asistencia Social. Los resultados se organizaron en los siguientes ejes analíticos: (1) (des)articulación de la red: impasse para el trabajo intersectorial; (2) redes en movimiento: prácticas profesionales en el cotidiano de cuidado; (3) tensiones entre los diferentes actores de la red de atención de alcohol y drogas. Tales resultados expresan la realidad de gran parte de los municipios brasileños, en los que las acciones en el ámbito de las políticas públicas ocurren de manera desarticulada, siendo aún el principio de la intersectorialidad un horizonte a ser construido. (AU)

Conscientização para Transformação social: Apontamentos para a Psicologia Social Comunitária / Conscientization for social transformation: appointments for community social psychology

O presente artigo trata-se de um estudo teórico que objetivou analisar a incorporação da categoria "conscientização" no campo da Psicologia Social Comunitária (PSC), de modo a refletir sobre o complexo arcabouço teórico que constitui tal pressuposto e os desafios que são colocados para a prática profissional da(o) psicóloga(o) comunitário(a) inserida(o) no atual contexto social brasileiro. Para tanto, buscamos delinear as bases teóricas da categoria conscientização a partir de Paulo Freire e sua adoção por percussores da psicologia social latino-americana, como Ignácio Martín-Baró e Maritza Montero. Em seguida, discorremos sobre os possíveis impasses teórico-metodológicos enfrentados por profissionais da psicologia para a concretização de ações de conscientização nos espaços de atuação profissional e comunitária. Consideramos que os limites e possibilidades colocados para a tarefa de conscientização perpassam por uma análise histórica dos fenômenos sociais e subjetivos, em sua relação dialética, tornando-se cada vez mais necessário o resgate e fortalecimento de perspectivas críticas de atuação que assumam, em sua radicalidade, o ideário ético-político de Libertação

This article is a theoretical study that aimed to analyze the incorporation of the category "conscientization" in the field of Community Social Psychology (PSC), in order to reflect on the complex theoretical framework that constitutes such an assumption and the challenges that are posed for the professional practice of the community psychologist in the current Brazilian social context. Therefore, we seek to delineate the theoretical bases of the category of conscientization based on Paulo Freire and its adoption by latin american social psychology, such as Ignácio Martín-Baró and Maritza Montero. Then, we discuss the possible theoretical-methodological impasses faced by professionals in psychology to implement the conscientization in the spaces of professional and community action. We considers that the limits and possibilities placed on the task of conscientization involve a historical analysis of social and subjective phenomena, in their dialectical relationship, making it increasingly necessary to rescue and strengthen critical perspectives of action that they assume, in their radicality, the ethical-political perspective of Liberation