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Introduction: Lung cancer is still the leading cause of cancer among cancer patients. Although there are novel therapies as second line treatment for NSCLC, there is an issue for elderly patients. Patients and Methods: We collected retrospectively data from 60 patients >75 years of age. Thirty of these patients received nab-paclitaxel and first line treatment and were compared to thirty patients that received only best supportive care. Results: The median life of patients at the date of disease progression, although increased by the administration of the drug (92 days versus 70) was not confirmed statistically significantly (Mann-Whitney test: W = 280, p = 0.138). The administration of drug seems to keep stable the biological condition of patients (McNemar's test: χ2 = 0.033, p = 0.99). Patients with chemotherapy the death rate was increased by 50% as compared to those with best supportive care (12 vs 8), the median life until the unfortunate event surpassed statistically significantly the latter (150 days of life as compared to 108, Mann-Whitney test: W = 57.5, p = 0.045). Discussion: Nab-paclitaxel as a monotherapy could be considered as a first line treatment option for patients > 75 years of age without any previous cardiological medical history when compared to best supportive care.
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BACKGROUND: The aim of our study was to assess the health status and Physical Activity Level (PAL) of the elderly population and determine the role of health status and socioeconomic factors in PAL. MATERIAL/METHODS: A total of 84 subjects (65 men and 19 women) participated in this study. These individuals were living independently, and attending rehabilitation centers for the elderly in Thessaloniki, Greece. The mean age of the subjects was 74.4 years (SD 7.9). Data was collected with a special questionnaire regarding health status and PAL, during individual interviews. RESULTS: The mean PAL value was 1.519, SD 0.115. Significant positive correlation was found between PAL and educational level (r=0.286, p<0.05). Regarding the relation of illnesses to PAL, one-way ANOVA indicated that individuals under treatment for heart arrhythmia and myocardial infarction, as well as those who had undergone a by-pass operation, had higher PAL values (1.659+/-0.0649, 1.551+/-0.093 and 1.613+/-0.0978, respectively) compared to those not suffering from any of these disorders (1.512+/-0.112, 1.515+/-0.118 and 1.508+/-0.112 respectively, p<0.05 for each comparison). Cancer affected PAL negatively. CONCLUSIONS: In conclusion, the elderly spent most of their time carrying out low-intensity activities and did not participate in leisure activities of high or moderate intensity. Educational level was the only socio-economic factor that was correlated to PAL. The positive effect of certain disorders on PAL might be attributed to patients' compliance with physicians' instructions. Further research is necessary.
