Persistence of infectivity in elderly individuals diagnosed with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection 10 days after onset of symptoms: A cross-sectional study.

We performed viral culture of nasopharyngeal specimens in individuals aged 79 and older, infected with severe acute respiratory coronavirus virus 2 (SARS-CoV-2), 10 days after symptom onset. A positive viral culture was obtained in 10 (45%) of 22 participants, including 4 (33%) of 12 individuals with improving symptoms. The results of this small study suggest that infectivity may be prolonged among older individuals.

Progressive disseminated histoplasmosis in an apparently immunocompetent patient with a bioprosthetic aortic valve.

Histoplasma capsulatum is an endemic fungus in eastern Canada. This organism has a wide spectrum of manifestations ranging from isolated pulmonary to disseminated disease. The latter usually occurs in immunocompromised hosts or those with substantial environmental exposure. In rare instances, disseminated histoplasmosis can present as an endovascular infection or chronic progressive disseminated histoplasmosis. If not recognized, these entities are almost uniformly fatal. We report a case of an immunocompetent man with a history of longstanding constitutional symptoms. An infectious cause was initially presumed to be unlikely given the chronic nature of his presentation and an extensive series of negative investigations. A diagnosis was only obtained post-mortem upon the unusual detection of both yeast and hyphal forms in blood culture bottles inoculated with a bone marrow aspirate.

L'Histoplasma capsulatum est une mycose endémique dans l'est du Canada. Cet organisme présente un vaste spectre de manifestations, de l'atteinte pulmonaire isolée à la maladie disséminée. En général, la forme disséminée s'observe chez des hôtes immunodéprimés ou qui y ont été largement exposés dans l'environnement. Dans de rares cas, l'histoplasmose disséminée peut prendre la forme d'une infection endovasculaire ou d'une histoplasmose disséminée progressive chronique. Non diagnostiquées, ces entités sont pratiquement toujours fatales. Les auteurs déclarent le cas d'un homme ayant une histoire de symptômes constitutionnels de longue date. Au départ, la cause infectieuse était considérée comme peu probable étant donné la présentation chronique et la longue série d'explorations négatives. Le diagnostic n'a été posé qu'après le décès, lors de la détection inhabituelle des formes à levures et à mycélium dans les flacons d'hémoculture inoculés d'un aspirat de moelle osseuse.

Prevalence of Auto-antibodies in Pulmonary Tuberculosis.

The relationship between pulmonary tuberculosis and auto-antibodies remains undefined. In a study of 75 patients with pulmonary tuberculosis and 75 controls, the prevalence of auto-antibodies was assessed in a reference laboratory using a comprehensive panel with standardized methodology. No significant relationship was found between auto-antibody prevalence and pulmonary tuberculosis.

Sink-Related Outbreaks and Mitigation Strategies in Healthcare Facilities.

PURPOSE OF REVIEW: In this review, we summarize recent outbreaks attributed to hospital sinks and examine design features and behaviors that contributed to these outbreaks. The effectiveness of various risk mitigation strategies is presented. Finally, we examine investigational strategies targeted at reducing the risk of sink-related infections. RECENT FINDINGS: Outbreaks of hospital sink-related infections involve a diverse spectrum of microorganisms. They can be attributed to defects in sink design and hospital wastewater systems that promote the formation and dispersion of biofilm, as well as healthcare practitioner and patient behaviors. Risk mitigation strategies are often bundled; while they may reduce clinical cases, sink colonization may persist. Novel approaches targeting biofilms show promise but require more investigation. Emphasis should be placed on optimizing best practices in sink design and placement to prevent infections. Hospitals should consider developing a rational surveillance and prevention strategy based on the current design and state of their sinks.

A Cluster of Three Cases of Hantavirus Pulmonary Syndrome among Canadian Military Personnel.

Hantavirus pulmonary syndrome (HPS) is a rare illness in eastern Canada. We present three cases of HPS among military personnel in Quebec. The three cases shared a common exposure to mouse excreta while engaged in military training in Alberta, a western province of Canada.