RESUMEN
In experiments on Wistar rats, a simulated defect in the flat bones of the skull was filled with a collagen sponge of animal origin impregnated with BMP-2 or pure sponge; in control rats, the defect was left open. During follow-up, X-ray density of the collagen sponge in the experimental groups differed significantly. The results attest to the absence of spontaneous remodeling of the bone tissue under conditions modeled focal defect. Moreover, stimulation of reparative processes by the collagen matrix did not lead to positive dynamics. Saturation of the collagen sponge with BMP-2 in a concentration of 0.05 mg/ml allowed increasing Xray density of the bone starting from week 4.
Asunto(s)
Proteína Morfogenética Ósea 2/farmacología , Regeneración Ósea/efectos de los fármacos , Colágeno/química , Fracturas Óseas/terapia , Osteogénesis/efectos de los fármacos , Factor de Crecimiento Transformador beta/farmacología , Animales , Apósitos Biológicos , Densidad Ósea , Proteína Morfogenética Ósea 2/farmacocinética , Regeneración Ósea/fisiología , Colágeno/farmacología , Fracturas Óseas/diagnóstico por imagen , Fracturas Óseas/patología , Humanos , Masculino , Hueso Parietal/diagnóstico por imagen , Hueso Parietal/efectos de los fármacos , Hueso Parietal/cirugía , Ratas , Ratas Wistar , Proteínas Recombinantes/farmacocinética , Proteínas Recombinantes/farmacología , Factor de Crecimiento Transformador beta/farmacocinética , Microtomografía por Rayos XRESUMEN
The authors noted a number of peculiarities and positive moments in case of application of hip joint transosseous access after Kulish with 87 patients, aged 14-64 years, with deforming coxarthrosis, femoral head aseptic necrosis, coxa vara, congenital hip dislocation and femoral head epiphyseolysis. The access is simple, effective, comparatively low traumatic and can be successfully applied in hip joint reconstructive orthopedics.
Asunto(s)
Artroplastia/métodos , Articulación de la Cadera/cirugía , Adolescente , Adulto , Epífisis Desprendida/cirugía , Necrosis de la Cabeza Femoral/cirugía , Luxación Congénita de la Cadera/cirugía , Humanos , Persona de Mediana Edad , Osteoartritis de la Cadera/cirugía , Osteotomía/métodosRESUMEN
The authors have proposed a method of surgical treatment of posttraumatic coxa vara. The treatment was given to 19 patients aged 16 to 43 years. The essence of the operation consists in oblique intertrochanteric osteotomy of the femur, osteotomy of the lesser trochanter and a muscular pedicle graft formation from the lesser trochanter which is used in grafting the defect observed after the correction of the spatial position of the proximal end of the femur.