RESUMEN
Spinal cord stimulation (SCS) is a therapeutic modality for the treatment of various chronic pain conditions that has rapidly evolved over the past 50 years. Unfortunately, over time, patients implanted with SCS undergo a habituation phenomenon leading to decreased pain relief. Consequently, the discovery of new stimulation waveforms and SCS applications has been shown to prolong efficacy and reduce explantation rates. This article explores various SCS waveforms, their applications, and proposes a graded approach to habituation mitigation. We suspect the neural habituation phenomenon parallels that seen in pharmacology. Consequently, we urge further exploration of the early introduction of these stimulation strategies to abate spinal cord stimulation habituation.
RESUMEN
In this article, we propose a new diagnostic paradigm known as Chronic Abdominal Discomfort Syndrome (CADS). Patient's presentation centers around chronic abdominal pain not explained by acute pathology with or without accompanying dyspepsia, bloating, nausea and vomiting among other symptoms. The pathophysiology is noted to be neurogenic, possibly stemming from visceral sympathetic nerves or abdominal wall afferent nerves. Diagnosis is supported by signs or symptoms traversing clinical, diagnostic and functional criteria. Included is a tool which can assist clinicians in diagnosing patients with CADS per those domains. We hope to facilitate primary care physicians' and gastroenterologists' utilization of our criteria to provide guidance for selecting which patients may benefit from further interventions or evaluation by a pain physician. The pain physician may then offer interventions to provide the patient with relief.
RESUMEN
The Covid-19 virus pandemic is leading to a large number of deaths. There are forecasts that there will be an exponential increase in the number of such deaths across the globe because of this deadly virus. To arrest the spread of the virus in this situation, the supply of medical materials including PPE and body bags (also known as human remains pouch or cadaver bag) should be designed to stop the spread of the Covid-19 virus. Conventional body bags have shortcomings, which need to be addressed by a refined redesigning and use of appropriate materials to adequately match the requirements in the current Covid-19 situation. Current designs of the body bags do not allow the family member's sentiments towards the deceased and to cater to the desire of the family members to view the face of the deceased without exposing them to a strong possibility of infection from the cadaver. This is, therefore, a very traumatic experience to the family and in many cases, the cadaver is not handled with respect due to the unavailability of safe design body bags, which also exposes health workers to avoidable risk from the infections. Technopark@iitk has proposed an integrated 5-layer body bag to tackle this situation for Covid-19 deceased such that it is (1) leak-proof, (2) impermeable/water-proof, (3) strong enough for the purpose, (4) ergonomically designed, and (5) has provision to view the face of the dead body for family viewing before cremation/burial. This new design would keep the handling of the deceased body to a minimum during transportation from the hospital/site of death to a mortuary, and then to the home of the deceased/burial ground/crematorium, where it may be disposed-off along with the body in it, in a respectable manner, without putting people involved to the risk of infection.
RESUMEN
This paper describes a robust autonomous disinfection tunnel to disinfect external surfaces of COVID-19 virus such as clothes and open body sections in public places such as airports, office complexes, schools, and malls. To make the tunnel effective and highly efficient, it has been provided with two chambers with three disinfection processes. Due to the multiple processes, the possibility of neutralizing the virus is quite high and higher than other solutions available at this point for this purpose. Chamber 1 sprays the solution of a disinfectant on the person. This solution can be either a dilute solution of approved chemical or any Ayurvedic/herbal disinfectant. Once the person enters chamber 2, he/she is exposed to hot air at 70 °C along with far-ultraviolet C rays (207-222 nm). Both chambers function autonomously by detecting a person in a chamber using ultrasonic sensors. The proposed tunnel is developed under industry-academia collaboration jointly by Technopark@iitk and ALIMCO under the ambit of the Ministry of Human Resources Development and the Ministry of Social Justice and Empowerment, respectively. The tunnel is referred to as the 'Techno Advanced Disinfection Tunnel' (TADT).
RESUMEN
With over 7 million people infected globally and over 5 lakh deaths reported worldwide by COVID-19 virus, World Health Organization (WHO) has declared it as a pandemic. India is also suffering badly because of the current crisis, with more than 4 lakh people infected and 13000 deaths reported as on 20th June 2020. There is no respite in sight as of now as the numbers continue to increase exponentially with each passing day. The only possible control to the virus is the availability of a vaccine, which will take a few months to be available to masses. Till then, the global economy has to start reopening slowly with several precautionary measures in place as advised by the WHO, such as mandatory wearing of masks in public places, frequent hand washing, practising good personal hygiene, and social distancing. Recently, the government of India (GoI) has also opened its economy with all the precautionary measures in place. Disinfecting of places of work, modes of transport, hospitals, and common areas is emerging as a mammoth challenge. With the objective of arresting the spread of COVID-19 virus and providing an efficient solution to the above problem, a portable disinfectant device is designed. Undertaken as an Industry-academia collaboration, it is a joint initiative between Technopark@iitk (IIT Kanpur Research and Technology Park) and Industry. The novelty of this device lies in its innovative design that combines spraying of sanitising liquid and UV light-based disinfection methodologies. For this, the device uses two separate disinfection systems: (1) the pump-nozzle assembly for spraying the disinfectant, and (2) UV-C radiations to increase the virus kill efficiency.
RESUMEN
RATIONALE: Cocaine produces significant aversive/anxiogenic actions whose underlying neurobiology remains unclear. A possible substrate contributing to these actions is the serotonergic (5-HT) pathway projecting from the dorsal raphé (DRN) to regions of the extended amygdala, including the bed nucleus of the stria terminalis (BNST) which have been implicated in the production of anxiogenic states. OBJECTIVES: The present study examined the contribution of 5-HT signaling within the BNST to the anxiogenic effects of cocaine as measured in a runway model of drug self-administration. METHODS: Male Sprague-Dawley rats were fitted with bilateral infusion cannula aimed at the BNST and then trained to traverse a straight alley once a day for a single 1 mg/kg i.v. cocaine infusion delivered upon goal-box entry on each of 16 consecutive days/trials. Intracranial infusions of CP 94,253 (0, 0.25, 0.5, or 1.0 µg/side) were administered to inhibit local 5-HT release via activation of 5-HT1B autoreceptors. To confirm receptor specificity, the effects of this treatment were then challenged by co-administration of the selective 5-HT1B antagonist NAS-181. RESULTS: Intra-BNST infusions of the 5-HT1B autoreceptor agonist attenuated the anxiogenic effects of cocaine as reflected by a decrease in runway approach-avoidance conflict behavior. This effect was reversed by the 5-HT1B antagonist. Neither start latencies (a measure of the subject's motivation to seek cocaine) nor spontaneous locomotor activity (an index of motoric capacity) were altered by either treatment. CONCLUSIONS: Inhibition of 5-HT1B signaling within the BNST selectively attenuated the anxiogenic effects of cocaine, while leaving unaffected the positive incentive properties of the drug.