Burning Mouth Syndrome in Association With Angular Cheilitis: A Case Report.

A burning sensation in the mouth without any obvious mucosal alterations is the hallmark of burning mouth syndrome, a chronic pain syndrome. BMS can worsen pain if it coexists with angular cheilitis, a condition characterized by inflammation around the corners of the mouth. Conventional therapies for angular cheilitis and burning mouth syndrome sometimes have unfavorable side effects and offer only little relief. When ozone is combined with oil, it accelerates tissue repair and oxygenation while destroying germs, fungi, and viruses. Triphala is a traditional treatment for oral health problems because of its anti-inflammatory, antioxidant, and antibacterial qualities. The effectiveness of alternative medicines, particularly ozonated oil, and triphala, a traditional herbal combination, in treating these diseases is examined in this case study. A 72-year-old woman reported a burning sensation in her mouth. The patient described the prolonged heat or burning sensation in the anterior two-thirds of her tongue. She was diagnosed with angular cheilitis and burning mouth syndrome. Conventional treatments, such as topical steroids and antifungal drugs, have not been effective. The patient was instructed to apply ozonated oil topically to the affected regions twice daily and to rinse their mouth with triphala. The patient reported full healing of the angular cheilitis lesions and considerable alleviation from burning feelings following two weeks of therapy. The patient noticed a significant decrease in the burning sensation in her mouth, characterized by a lack of discomfort, irritation, or pain. Throughout the treatment, no side effects were seen. According to this case study, ozonated oil and triphala may be useful in treating the symptoms of angular cheilitis and burning mouth syndrome, providing an alternative to traditional treatments.

Clinical Management of Dewey's Type 3 Anterior Crossbite in Angle Class I Malocclusion: A Case Report.

Anterior crossbite is a significant malocclusion characterized by the lingual eruption of one or more maxillary front teeth, often impeded by the mandibular deciduous counterparts. This clinical case study focused on a patient with an anterior crossbite involving the central and lateral incisors, detailing the diagnosis, treatment course, and outcomes. During the clinical evaluation, both aesthetic concerns related to attrition and occlusal malocclusion were identified. Diagnostic tests, including radiographs and extraoral and intraoral examinations, were conducted before initiating treatment. The treatment aimed to correct the anterior crossbite while enhancing function and aesthetics. Fixed orthodontic appliances were introduced to facilitate precise tooth movement. Throughout the first year, the alignment, crossbite correction, and occlusal refinement were meticulously documented through photographs. The treatment resulted in improved occlusal relationships, functional bite, and enhanced smile aesthetics. This case report underscores the importance of comprehensive and functional orthodontic treatment in effectively resolving anterior crossbite and providing optimal patient care.

A More Aesthetically Pleasing Smile: A Case Report on the Impact of Scalpel Technique on Gingival Depigmentation.

Gingival hyperpigmentation can significantly affect how the smile looks cosmetically, leading patients to seek treatment. This case report addresses the use of a scalpel approach combined with bur abrasion for gingival depigmentation in a 19-year-old female patient who was displeased with her "black" gums. A local anesthetic was required for the surgical removal of the pigmented epithelium and a thin layer of connective tissue. Post-operative care included antibiotics and analgesics, with chlorhexidine mouthwash use for optimal healing. Follow-up examinations showed successful depigmentation without complications. This simple method is a good choice for gingival pigmentation management since it provides satisfactory cosmetic results and patient satisfaction.

Gingivectomy as a Treatment for Orthodontic-Induced Gingival Enlargement.

The side effects of an antipsychotic drug, such as fibrous overgrowth and gingival inflammation, or a combination of both, can lead to gingival enlargement. Causes for developing plaque include neglected cleanliness, architectural differences disturbing contact, faulty restorative buildup, cavities, and orthodontic appliances. Hence, in actual clinical scenarios, finding out the exact reason with precision is the key to appropriate therapeutic intervention. The presented clinical case is about a 29-year-old female patient who was referred to the Department of Periodontics due to a swollen gums complaint. The drug administration was first done, with the second step constituting surgical reduction of excessive gingival tissue under local anesthesia using gingivectomy. After the surgery, an application of GC Coe-Pack (GC America Inc., USA) was made that acted as a dressing for the tissue and promoted healing. Follow-up was done to assess the patient's gingival and periodontal conditions as requested through recall. In the post-procedure circumstances following that, the ideal gingival height was reached. All the results were healthy in the given case presentation with no remaining supra bony pockets, achieving natural-looking gingival architecture, thus enhancing esthetics and decreasing plaque accumulation. The interventions of surgical gingivectomy can be deemed effective in this case.

Retained Primary Teeth and Their Complication and Treatment: A Case Report.

In dentistry, over-retained deciduous teeth pose a distinct issue due to their endurance during the expected exfoliation period. This case study describes a clinical situation with a male patient who is seven years old and complaining of painful swelling over the maxillary anterior region of the jaw and clinically showing dark red-colored, firm, non-tender, purulent swelling extending from alveolar mucosa of the upper anterior to the gingival margin of the 51, 52, 53 region. The treatment plan includes the extraction of the primary teeth. This case report also highlights the importance of minimal surgical intervention for treating peri-radicular cysts to minimize healing time and damage to the underlying developing permanent tooth.

Misdiagnosis of an Odontogenic Infection as a Skin Lesion: The Diagnostic Dilemma.

Extraoral sinus tracts of endodontic origin might be confused for a variety of dermatological conditions. Differential diagnosis of this clinical condition plays an essential role in providing appropriate clinical care because misdiagnosis is the most prevalent cause of prolonged therapy and healing failure. As a result, every cutaneous sinus structure affecting the face or neck should be investigated for dental issues. Its diagnosis can sometimes be difficult until the treating clinician examines the potential of a dental cause. Once an appropriate diagnosis has been established, definitive treatment, consisting of root canal therapy or tooth extraction, to remove the primary source of infection is a straightforward and successful operation.

Novel drug delivery systems in colorectal cancer: Advances and future prospects.

Colorectal cancer (CRC) is an abnormal proliferation of cells within the colon and rectum, leading to the formation of polyps and disruption of mucosal functions. The disease development is influenced by a combination of factors, including inflammation, exposure to environmental mutagens, genetic alterations, and impairment in signaling pathways. Traditional treatments such as surgery, radiation, and chemotherapy are often used but have limitations, including poor solubility and permeability, treatment resistance, side effects, and post-surgery issues. Novel Drug Delivery Systems (NDDS) have emerged as a superior alternative, offering enhanced drug solubility, precision in targeting cancer cells, and regulated drug release. Thereby addressing the shortcomings of conventional therapies and showing promise for more effective CRC management. The present review sheds light on the pathogenesis, signaling pathways, biomarkers, conventional treatments, need for NDDS, and application of NDDS against CRC. Additionally, clinical trials, ongoing clinical trials, marketed formulations, and patents on CRC are also covered in the present review.

Determining the Emotional Intelligence and Compassion Fatigue Among Postgraduate Dental Students Using the Emotional Intelligence Scale and the Quality of Life Scale: An Observational Study.

Introduction Compassion fatigue (CF) is a problem for professionals who work with traumatized individuals. CF manifests as reliving personal sorrow, nightmares, flashbacks, intrusive thoughts, numbing or avoiding memories of the experience, and elevated physiological arousal. CF makes professionals more likely to make bad choices, such as misplacing treatments or mistreating patients. Emotional intelligence (EI) is essential to comprehending human behavior, performance, and well-being. EI is a crucial component of professional competency in medical education, as postgraduate dental students are also at risk of having CF. They are professionals and have to work with traumatized patients, so the study was conducted to evaluate their CF and EI. This study aimed to evaluate EI and CF among postgraduate dental students at Sharad Pawar Dental College and Hospital, Wardha, India. Materials The observational study was conducted at Sharad Pawar Dental College and Hospital among postgraduate dental students. The data was collected from 80 postgraduate students who responded to the Professional Quality of Life Version 5 and the Emotional Intelligence Scale questionnaires. Result A total of 80 postgraduate dental students responded to the Professional Quality of Life Version 5 and the Emotional Intelligence Scale questionnaires, and all the responses were included in the study. Findings revealed that postgraduate dental students treating patients have high levels of CF and EI. Conclusion This study indicates that there is a high level of CF and EI in postgraduate dental students. As high CF is harmful and can affect physical and mental well-being, proper management should be done through psycho-education and self-care.

Botox: Current and Emerging Trends for Dental Practitioners in Esthetic Dentistry.

There are numerous medical and dental disorders for which there are no effective traditional therapy options. For various medical and dental disorders, botulinum toxin (BT) can be employed as an alternate therapeutic option that uses the chemodenervation approach. The range of dentistry treatment choices is expanding quickly. Applications of non-traditional therapy alternatives, such as the use of BT, are becoming more and more common in this situation. Although BT has been shown to be effective in a number of circumstances, its application in esthetic operations, such as the treatment of facial wrinkles, has gained widespread acceptance. This research is especially interested in applications of BT related to dentistry in the craniofacial region. For many diseases that a dentist would be interested in treating, BT provides a temporary, reversible, and generally safe therapy option. Due to their extensive knowledge of the anatomy of the faciomaxillary region, dental surgeons are a potential pool of operators who, with a small amount of skill enhancement, can use BT in their toolkit. This broadens the scope of minimally invasive alternatives to invasive protocols or refractory conditions. An online search was conducted for the use of BT in dentistry; all studies and articles pertaining to the subject were chosen, and dental-related content was removed and summarized. The fundamentals of BT and some of its applications in dentistry are covered in this article. The comprehensive details of its application in dentistry will be covered in the upcoming sections.

Pin-Retained Amalgam: An Intricate Restorative Case Study.

Amalgam has made dental restorations more manageable, especially in difficult cases, due to its strength, durability, and relatively low cost. There can be pros and cons of each dental material depending on which class of cases it is applied or not applied for, depending on the patient's need, and, of course, the dentist's choice. These materials are used frequently for their hardness and durability and are ideal for extensive restoration procedures. On the other hand, composite resins are considered to be more aesthetic for the profitable areas where esthetics are more important. In contrast, glass ionomer cement is considered to be ideal for low-stress-bearing areas. The following case report of pin-retained amalgam restoration presents an example of its application in practical situations and the factors that must be considered to justify the use of this material against others. This paper explains various factors in considering pin-retained amalgam restorations and the procedure for a better and positive outcome.

Quercetin in Oncology: A Phytochemical with Immense Therapeutic Potential.

Quercetin is a natural flavonoid with various pharmacological actions such as anti-inflammatory, antioxidant, antimicrobial, anticancer, antiviral, antidiabetic, cardioprotective, neuroprotective, and antiviral activities. Looking at these enormous potentials, researchers have explored how they can be used to manage numerous cancers. It's been studied for cancer management due to its anti-angiogenesis, anti-metastatic, and antiproliferative mechanisms. Despite having these proven pharmacological activities, the clinical use of quercetin is limited due to its first-- pass metabolism, poor solubility, and bioavailability. To address these shortcomings, researchers have fabricated various nanocarriers-based formulations to fight cancer. The present review overshadows the pharmacological potential, mechanisms, and application of nanoformulations against different cancers.

Management of Aberrant Frenum and Gingival Overgrowth in Orthodontic Patients: A Case Report.

The frenum, a fold of mucous membrane, connects the lip and cheek to the alveolar mucosa, gingiva, and underlying periosteum. When the frenum is positioned excessively near the gingival margin, it has the potential to compromise gingival health, impeding plaque control efforts and inducing muscular stress. A frenectomy is a commonly employed corrective measure for anomalous frenum attachments. In a recent clinical case, a 21-year-old female patient was referred from the Department of Orthodontics to the Department of Periodontics due to a papillary-type aberrant labial frenum attachment and excessive gingival tissue surrounding the upper right and left central incisors. The patient underwent a frenectomy, gingivectomy, and gingivoplasty procedures under local anesthesia to address the abnormal frenum attachment and gingival overgrowth using a scalpel. This approach has been demonstrated to yield optimal outcomes in orthodontic therapy for patients exhibiting elevated frenum attachment and gingival overgrowth. Following the achievement of hemostasis, a periodontal pack was applied to facilitate healing and preserve the soft tissue.

Evaluating the Impact of Chronic Care Model on Smoking Cessation: An Interventional Study.

BACKGROUND: This study aims to assess the effectiveness of the chronic care model (CCM) in helping primary healthcare workers quit smoking. The intervention involves implementing the CCM, which includes six key elements: the healthcare system, clinical care planning, clinical management information, self-management guidance, community resources, and decision-making. MATERIAL AND METHODS: The study is based on a population of 60 primary healthcare workers who smoke. The main outcome measure is smoking cessation, determined by cotinine levels in urine at the baseline, and at 6 and 12 months after the intervention. Other potential results include alterations in smoking-related behaviors and attitudes. Data analysis involves using descriptive statistics and inferential tests to determine the intervention's effectiveness in smoking cessation among primary healthcare workers. RESULTS:  The CCM is expected to have contributed to a substantial decrease in the smoking rate among primary healthcare workers. It is also seen that there is a great reduction in urine cotinine levels during the 12-month intervention period. Moreover, a positive shift in the smoking-related behaviors and attitudes of the participants is expected. CONCLUSION:  This study provides key data about the effectiveness of the CCM in helping primary healthcare workers stop smoking. This statement emphasizes the importance of considering socioeconomic factors in the design and implementation of smoking cessation interventions. This ensures that people of different incomes and social statuses have equal access to quitting smoking and achieve similar results.

Investigating the potent TOPO IIα inhibitors in breast cancer through the study of computational drug discovery research approaches.

Breast cancer (BC) is the second-leading cause of cancer after lung cancer. The disease has affected millions of people and resulted in many deaths. In the metastasis of breast cancer cells, Topoisomerase IIα plays a vital role. Therefore, this investigation aims to identify potential flavonoid compounds against BC by inhibiting this enzyme at an early stage. Based on previous studies, we selected and screened several plant-derived flavonoid compounds with potential anti-breast cancer activity using PyRx 0.8 and Schrodinger applications for preliminary molecular docking: the highest docking scores of Myricetin (-11.6 kcal/mol) and Quercetin (-10.0 kcal/mol). Next, we evaluated the top four compounds on the Way2Drug server to complete the cytotoxicity evaluation, which demonstrated anti-cancer and anti-breast cancer activity in various cell lines. According to pharmacokinetics studies, four compounds exhibited outstanding values and functioned similar to drug-like molecules. Moreover, Myricetin, Quercetin, and Morin displayed the highest number of hydrogen bonds, with the corresponding receptor forming residues asn120, thr147, and lys168. The protein-ligand complexes were validated using the Desmond simulator, and their data were compared to the anti-breast cancer drug Doxorubicin. In the simulation analysis, various parameters were evaluated, including RMSD, RMSF, Rg, SASA, MolSA, PSA, and hydrogen bond interaction. Finally, validated our dynamic simulation result with MM-GBSA operation, and Myricetin and Quercetin had the greatest score of -72.74344651, -66.66771823 kcal/mol, which is outstanding than the control drug. Hence, the computational research approach determined that Myricetin, Quercetin, and Morin could be industrially developed for the alternative treatment of breast cancer following additional confirmation from animal and cell line studies.

A Comparative Analysis of Skeletal and Dental Parameters in Bilateral Cleft Lip and Palate vs. Non-bilateral Cleft Lip and Palate Patients in the Central Indian Population: A NemoCeph Study.

Introduction Orthodontic diagnosis and treatment planning encounter distinctive complexities when dealing with cleft lip and palate anomalies. This research endeavors to thoroughly examine skeletal and dental characteristics through cephalometric analyses among individuals with bilateral cleft lip and palate (BCLP) within the central Indian population. Due to anatomical variations and growth constraints, traditional cephalometric mean values derived from standard population studies are often inadequate for these cases. Advanced technology, such as NemoCeph (Nemotech, Madrid, Spain) software, enhances measurement accuracy. Methods Fifty patients, including 25 with BCLP and 25 without BCLP, aged 10 to 18, were selected for this cross-sectional study. Lateral cephalograms were traced and analyzed using NemoCeph software. Skeletal and dental parameters were measured, and a comparison was made between BCLP patients and the general population. Statistical analysis was conducted using the Student's unpaired t-test. Both SPSS Statistics Version 24.0 (IBM Corp., Armonk, NY, USA) and GraphPad Prism Version 7.0 (GraphPad Software, San Diego, CA, USA) were used for data analysis. Results The investigation revealed significant disparities across several parameters, including sella-nasion-A point angle (SNA), sella-nasion-B point angle (SNB), A point-nasion-B point angle (ANB), the inter-incisal angle (the angle between the long axes of the upper and lower incisors), and UP 1 to A-pog (a specific vertical measurement between anatomical markers labeled "upper 1" and "A point to pogonion"), with associated p-values for the skeletal and dental parameters of 0.310, 0.259, 0.195, 0.0001, and 0.0001, respectively. A comparison between manual tracing and digital methods indicated a reduction in errors and an improvement in measurement precision. Notably, patients diagnosed with BCLP exhibited distinctive skeletal and dental traits, highlighting the necessity for tailored treatment approaches. Conclusion This study emphasizes the importance of personalized cephalometric evaluations for patients with BCLP. Standard mean values may not be applicable due to unique anatomical considerations in these cases. Advanced technology and patient-specific assessments are crucial for accurate diagnosis, treatment planning, and orthognathic procedures in individuals with cleft lip and palate conditions. Embracing digital tools and tailored approaches can enhance patient care quality and lead to better clinical outcomes.

Copper(II)-Mediated, Site-Selective C(sp2)-H Sulfonamidation of 1-Naphthylamines.

An operationally simple and efficient protocol for copper(II)-mediated, picolinamido-directed C8-H sulfonamidation of 1-naphthylamine derivatives with various sulfonamides has been developed. Remarkably, this cross-dehydrogenative C-H/H-N coupling reaction exhibits a broad substrate scope with excellent functional group tolerance, is scalable, and enables an expeditious route to a library of unsymmetrical N-arylated sulfonamides in good to excellent yields with exclusive site selectivity.

Noninvasive Technique for the Screening and Diagnosis of Oral Squamous Cell Carcinoma.

Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancy. Squamous cell carcinoma is the second-most prevalent type of cutaneous malignancy after basal cell carcinoma. Biopsy followed by histopathological assessment is the primary basis for assessing squamous cell carcinoma, but nowadays optical non-invasive screening modalities are gaining more importance. There has been an emphasis on implementing relatively quick, affordable, and non-invasive screening methodologies because of various limitations associated with conventional screening techniques, including the encroaching characteristic of the biopsy technique, and the increased price value for treatment. Liquid biopsy, optical detection systems, oral brush cytology, and microfluidic detection, are a few examples of these, each of which has advantages and disadvantages of their own. Dermoscopy is one of the fundamental non-invasive screening techniques used for the examination of cutaneous lesions in clinical practice. Optical coherence tomography and high-frequency ultrasound are considered to be beneficial, particularly for assessing the dimensions of tumors before surgery. The primary site of the lesions, tumor diameter, and the state of the operative borders are some factors that can influence prognosis.