Asunto(s)
Dihidrotestosterona/sangre , Inhibidores Enzimáticos/administración & dosificación , Finasterida/administración & dosificación , Hirsutismo/tratamiento farmacológico , Administración Tópica , Colestenona 5 alfa-Reductasa , Relación Dosis-Respuesta a Droga , Sistema Endocrino/fisiología , Femenino , Hirsutismo/metabolismo , Humanos , Oxidorreductasas/antagonistas & inhibidores , Oxidorreductasas/metabolismo , Testosterona/sangre , Insuficiencia del TratamientoRESUMEN
Injection of carbachol into the brainstem of rats produced an increase in rapid eye movement (REM) sleep which was site- and dose-dependent. Effective locations for carbachol to stimulate REM sleep included the pontine reticular formation at the level of the trigeminal motor nucleus and the dorsal parabrachial area in the caudal midbrain. The carbachol effect in the caudal pons was dose-dependent. Additionally, this effect was blocked by concomitant administration of the muscarinic antagonist atropine. Control experiments suggested that the drug-induced phenomenon appeared to be an increase in normal physiological REM sleep.
Asunto(s)
Tronco Encefálico/fisiología , Fibras Colinérgicas/fisiología , Sueño REM/fisiología , Animales , Atropina/farmacología , Autorradiografía , Conducta Animal/efectos de los fármacos , Tronco Encefálico/efectos de los fármacos , Carbacol/análisis , Carbacol/farmacología , Fibras Colinérgicas/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Electroencefalografía , Masculino , Ratas , Ratas Endogámicas , Sueño REM/efectos de los fármacosRESUMEN
Acute administration of the organophosphate diisopropyl-fluorophosphate (DFP) produces behavioral and physiological symptoms indicative of excessive cholinergic stimulation. This behavioral toxicity was found to be incompatible with the occurrence of sleep, despite the fact that chronic administration of DFP has been shown to increase the rapid eye movement stage of sleep. DFP was found to decrease all stages of sleep and to increase wakefulness in a dose-dependent manner. Atropine sulfate, at doses of 3.0 mg/kg, was ineffective in blocking the DFP effects upon sleep.
Asunto(s)
Conducta Animal/efectos de los fármacos , Isoflurofato/toxicidad , Sueño/efectos de los fármacos , Animales , Atropina/farmacología , Peso Corporal , Relación Dosis-Respuesta a Droga , Femenino , Inyecciones , Isoflurofato/metabolismo , Ratas , Ratas Endogámicas , Fases del Sueño/efectos de los fármacos , Vigilia/efectos de los fármacosRESUMEN
In this experiment, rats were treated chronically with moderate doses of the acetylcholinesterase inhibitor di-isopropyl-fluorophosphate (DFP). After an initial injection of 1.0 mg/kg DFP, the rats received a 0.5 mg/kg injection every third day thereafter for a total of 5 injections (13 days). Following the treatment regimen, the rats were found to have increased amounts of REM sleep compared to vehicle control rats. The time spent awake and in slow wave sleep was relatively unaffected. The increase in REM sleep appears to be due to increased numbers of REM sleep episodes and not an increase in the average length of the REM sleep episodes. Furthermore, the increased REM sleep does not appear to be due to REM rebound or to disruptions of circadian rhythm.
Asunto(s)
Isoflurofato/farmacología , Sueño REM/efectos de los fármacos , Animales , Encéfalo/fisiología , Fibras Colinérgicas/fisiología , Femenino , Ratas , Ratas Endogámicas , Sueño REM/fisiología , Estimulación QuímicaRESUMEN
An automated technique for the continuous analysis of selected EEG frequency bands as a function of drug treatment is described. Experiments utilizing this analytical method have shown that the convulsive effects of GHB are antagonized by dipropylacetate, but that the effects of GHB exhibit a latent irreversibility.
