[Pathological parameters of endometrial cancer and presence of metastases in pelvic lymph nodes]. / Patomorfologiczne cechy raka endometrium, a obecnosc przerzutów w wezlach chlonnych miednicznych.

Endometrial cancer has become a more frequent neoplasm of the female genital tract. The role of lymphadenectomy in surgical treatment of this neoplasm has not been finally defined. The aim of the study was to determine relationship between pathological parameters of endometrial cancer and presence of metastases in pelvic lymph nodes. Forty one patients with endometrial cancer were treated by extended hysterectomy with pelvic lymphadenectomy. The precise Fisher test and logistic regression test were applied in the analysis of relationship. An intrinsic connection between presence of metastases in pelvic lymph nodes and cancer grade, depth of myometrium infiltration depth and infiltration of vascular spaces was found. On the other hand, histological type of neoplasm and characteristic of its growth does not seem to have connection with presence of metastases in pelvic lymph nodes. Pelvic lymphadenectomy seems to give profound information of of process advancement and indications for supplementary treatment.

[Changes in ovaries after hysterectomy]. / Zmiany zachodzace w jajnikach po usunieciu macicy.

Although simple hysterectomy is one of the most frequent gynecological operations, there is still the lack of clear criterions to the procedure with macroscopic unchanged ovaries in perimenopausal term. The aim of study was to examine setting changes in ovaries after hysterectomy. The study included 40 women aged between 40 and 49 years, who underwent hysterectomy due to myoma, leaving their bilateral changes in ovaries connected with age two study groups were distinguished, the first group included 21 patients aged 40-44 years and the second one--19 patients aged 45-49 years. The occurring of pathological changes in remaining ovaries and changes in ovaries function were estimated. The period of observation lasted two years. The function of ovaries was observed by estimation of FSH and of E2 and of total volume of ovaries before operations and after 6, 12, 24 months following hysterectomy. The results of observation were compared with similar marks of female patients with intact uterus and were exactly in the same age group. Pathological changes of uterine appendages as ovary cyst that needed a repeat operation was in 1 patient-(2.5%) The fundamental statistical differences in level of FSH and of E2, volume of ovaries between examined and controlled groups were not important. Also the trends in changes of the level of these parameters taking place during the observation in both study groups were not statistically significant. On the basis of the examinations it can be stated that the hysterectomy in the group of women at the age 40-49--doesn't have an influence on function of remaining ovaries. The decision how to treat the ovaries in case of hysterectomy should take into consideration the results of an interview and individual patient's preferences.

[A clinical assessment of a 3 month replacement therapy effectiveness with low norethisterone acetate (Activelle) in postmenopausal women]. / Ocena kliniczna trzymiesiecznej terapii substytucyjnej przy zastosowaniu niskich dawek estradiolu i octanu norethisteronu w postaci leku Activelle u kobiet po menopauzie.

AIM: The clinical evaluation of Activelle formula in treatment of climacteric symptoms in postmenopausal women. MATERIAL AND METHODS: Formula Activelle (oral 1 mg 17 beta-estradiol combined with 0.5 mg norethisterone acetate) was applied daily in 100 post-menopausal women during 3 months. The control group consisted of 20 women. Initially and at the 3rd month body mass, body mass index, systolic and diastolic blood pressure, AspAT and AIAT levels as well as total cholesterol, triglycerides, FSH and 17 beta-estradiol levels were measured. Green scale was used to assess the severity of menopausal symptoms. RESULTS: Mean FSH levels decreased and mean estradiol level increased in plasma significantly in women who were given Activelle formula. Only vasomotoric group of symptoms in Green scale was reduced after 3 month therapy in women who had activelle administered. No significant change was found in regard to other parameters. CONCLUSION: Formula Activelle seems to be efficient in removal of vasomotoric menopausal symptoms after 3 month of therapy. The administration of Activelle formula enables to reach the serum estradiol level which is sufficient in prophylaxis of osteoporosis.