RESUMEN
Evaluation of lipid peroxidation in patients with occupational allergic dermatoses revealed activation of free radical oxidation. Serum levels of diene conjugates and end products of free radical lipid peroxidation appeared to be informative parameters for assessing influences on body system and for estimating the disease severity and the individual protective means efficiency.
Asunto(s)
Industria Química , Dermatitis Profesional/metabolismo , Peroxidación de Lípido/fisiología , Exposición Profesional/efectos adversos , Adulto , Antioxidantes/metabolismo , Antioxidantes/envenenamiento , Dermatitis Profesional/sangre , Dermatitis Profesional/clasificación , Femenino , Depuradores de Radicales Libres/metabolismo , Depuradores de Radicales Libres/envenenamiento , Humanos , Masculino , Persona de Mediana Edad , Índice de Severidad de la Enfermedad , Factores de Tiempo , Recursos HumanosRESUMEN
Evaluation of genes polymorphic system of xenobiotics biotransformation in patients with occupational allergodermatoses showed significantly higher percentage of incidence of polymorphic variants of genes CYP 1A1 *2C and EPHX1 AND-415G compared with population control. A combination of 3 or more adverse hetero--and homozygous gene alleles CYP 1A1, CYP3A4, EPHX1 and deletions of genes GSTM1 and GSTT1, is characterized by earlier (with the experience of work in harmful conditions up to 5 years) development, severe and unfavorable prognosis of occupational pathology of the skin.
