1.
Infect Immun
; 65(6): 2454-6, 1997 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-9169790
RESUMEN
In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor necrosis factor alpha independent and required the presence of monocytes and plasma. Since IL-6 can stimulate replication of the human immunodeficiency virus in monocytic cells, these findings may be clinically relevant.
Asunto(s)
Cryptococcus neoformans/fisiología , Interleucina-6/biosíntesis , Monocitos/metabolismo , Síndrome de Inmunodeficiencia Adquirida/metabolismo , Humanos , Glicoproteínas de Membrana/farmacología , Polisacáridos/farmacología , Polisacáridos Bacterianos/farmacología , Factor de Necrosis Tumoral alfa/fisiología
2.
Adv Exp Med Biol
; 418: 945-7, 1997.
Artículo
en Inglés
| MEDLINE
| ID: mdl-9331806