Age Differences in Gaze Following: Older Adults Follow Gaze More than Younger Adults When free-viewing Scenes.

Previous research investigated age differences in gaze following with an attentional cueing paradigm where participants view a face with averted gaze, and then respond to a target appearing in a location congruent or incongruent with the gaze cue. However, this paradigm is far removed from the way we use gaze cues in everyday settings. Here we recorded the eye movements of younger and older adults while they freely viewed naturalistic scenes where a person looked at an object or location. Older adults were more likely to fixate and made more fixations to the gazed-at location, compared to younger adults. Our findings suggest that, contrary to what was observed in the traditional gaze-cueing paradigm, in a non-constrained task that uses contextualized stimuli older adults follow gaze as much as or even more than younger adults.

Adult Age Differences in Using Information From the Eyes and Mouth to Make Decisions About Others' Emotions.

OBJECTIVES: Older adults are often less accurate than younger counterparts at identifying emotions such as anger, sadness, and fear from faces. They also look less at the eyes and more at the mouth during emotion perception. The current studies advance understanding of the nature of these age effects on emotional processing. METHODS: Younger and older participants identified emotions from pictures of eyes or mouths (Experiment 1) and incongruent mouth-eyes emotion combinations (Experiment 2). In Experiment 3, participants categorized emotions from pictures in which face masks covered the mouth region. RESULTS: Older adults were worse than young at identifying anger and sadness from eyes, but better at identifying the same emotions from the mouth region (Experiment 1) and they were more likely than young to use information from the mouth to classify anger, fear, and disgust (Experiment 2). In Experiment 3, face masks impaired perception of anger, sadness, and fear more for older compared to younger adults. DISCUSSION: These studies indicate that older people are more able than young to interpret emotional information from the mouth, they are more biased to use information from the mouth, and suffer more difficulty in emotion perception when the mouth is covered with a face mask. This has implications for social communication in different age groups.

The Effects of Adult Aging and Culture on Theory of Mind.

OBJECTIVES: Older adults tend to have poorer Theory of Mind (ToM) than their younger counterparts, and this has been shown in both Western and Asian cultures. We examined the role of working memory (WM) in age differences in ToM, and whether this was moderated by education and culture (the United Kingdom vs. Malaysia). METHODS: We used 2 ToM tests with differing demands on updating multiple mental states (false belief) and applying social rules to mental state processing (faux pas). We also looked at the role of education, socioeconomic status, and WM. A total of 298 participants from the United Kingdom and Malaysia completed faux pas, false belief, and WM tasks. RESULTS: Age effects on some aspects of ToM were greater in the Malaysian compared to the UK sample. Malaysian older adults were poorer at faux pas detection, aspects of false belief, and WM compared to young adults. In subsequent moderated mediation analyses, we found that, specifically in the Malaysian sample, the mediating effects of WM on the age and ToM relationship occurred at the lowest levels of education. DISCUSSION: This pattern of results may reflect changes in the familiarity and cognitive load of explicit mental state attribution, along with cultural differences in the pace and nature of cognitive aging. Cultural differences in education and WM should be considered when researching age differences in ToM.

The interplay between gaze and consistency in scene viewing: Evidence from visual search by young and older adults.

Searching for an object in a complex scene is influenced by high-level factors such as how much the item would be expected in that setting (semantic consistency). There is also evidence that a person gazing at an object directs our attention towards it. However, there has been little previous research that has helped to understand how we integrate top-down cues such as semantic consistency and gaze to direct attention when searching for an object. Also, there are separate lines of evidence to suggest that older adults may be more influenced by semantic factors and less by gaze cues compared to younger counterparts, but this has not been investigated before in an integrated task. In the current study we analysed eye-movements of 34 younger and 30 older adults as they searched for a target object in complex visual scenes. Younger adults were influenced by semantic consistency in their attention to objects, but were more influenced by gaze cues. In contrast, older adults were more guided by semantic consistency in directing their attention, and showed less influence from gaze cues. These age differences in use of high-level cues were apparent early in processing (time to first fixation and probability of immediate fixation) but not in later processing (total time looking at objects and time to make a response). Overall, this pattern of findings indicates that people are influenced by both social cues and prior expectations when processing a complex scene, and the relative importance of these factors depends on age.

The Effects of Adult Ageing and Culture on the Tower of London Task.

Planning ability is important in everyday functioning, and a key measure to assess the preparation and execution of plans is the Tower of London (ToL) task. Previous studies indicate that older adults are often less accurate than the young on the ToL and that there may be cultural differences in performance on the task. However, potential interactions between age and culture have not previously been explored. In the current study we examined the effects of age on ToL performance in an Asian culture (Malaysia) and a Western culture (British) (n = 191). We also explored whether working memory, age, education, and socioeconomic status explained variance in ToL performance across these two cultures. Results indicated that age effects on ToL performance were greater in the Malaysian sample. Subsequent moderated mediation analysis revealed differences between the two cultures (British vs Malaysians), in that the age-related variance in ToL accuracy was accounted for by WM capacity at low and medium education levels only in the Malaysian sample. Demographic variables could not explain additional variance in ToL speed or accuracy. These results may reflect cultural differences in the familiarity and cognitive load of carrying out complex planning tasks.

Multiple sclerosis, emotion perception and social functioning.

People with multiple sclerosis (MS) can experience problems in interpreting others' emotions from faces or voices. However, to date little is known about whether difficulties in emotion perception in MS are related to broader aspects of social functioning. Also, there are few studies reporting the effect of MS on more ecologically valid assessments of emotion perception using multimodal videos. The current study looks at (1) the effect of MS on perceiving emotions from faces, voices and multimodal videos; (2) the possible role of slowed processing and executive dysfunction in emotion perception problems in MS and (3) the relationship between emotion perception and broader social functioning in MS. 53 people with MS and 31 healthy controls completed tasks of emotion perception and cognition, and assessed their levels of social support and social participation. Participants with MS performed worse than demographically matched controls on all measures of emotion perception. Emotion perception performance was related to cognitive measures in those with MS. Also, significant associations were found between emotion perception difficulties in MS and poorer social function. In particular, people with MS who had poorer emotion perception also reported lower levels of social support from their friends, and regression analysis showed that this prediction was maintained even when disease severity and cognitive function were taken into account. These results show that problems with emotion perception in MS extend to more realistic tasks and may predict key aspects of social functioning.

Imprinting methylation predicts hippocampal volumes and hyperintensities and the change with age in later life.

Epigenetic imprinting is important for neurogenesis and brain function. Hippocampal volumes and brain hyperintensities in late life have been associated with early life circumstances. Epigenetic imprinting may underpin these associations. Methylation was measured at 982 sites in 13 imprinted locations in blood samples from a longitudinal cohort by bisulphite amplicon sequencing. Hippocampal volumes and hyperintensities were determined at age 64y and 72y using MRI. Hyperintensities were determined in white matter, grey matter and infratentorial regions. Permutation methods were used to adjust for multiple testing. At 64y, H19/IGF2 and NESPAS methylation predicted hippocampal volumes. PEG3 predicted hyperintensities in hippocampal grey matter, and white matter. GNASXL predicted grey matter hyperintensities. Changes with age were predicted for hippocampal volume (MEST1, KvDMR, L3MBTL, GNASXL), white matter (MEST1, PEG3) and hippocampal grey matter hyperintensities (MCTS2, GNASXL, NESPAS, L3MBTL, MCTS2, SNRPN, MEST1). Including childhood cognitive ability, years in education, or socioeconomic status as additional explanatory variables in regression analyses did not change the overall findings. Imprinting methylation in multiple genes predicts brain structures, and their change over time. These findings are potentially relevant to the development of novel tests of brain structure and function across the life-course, strategies to improve cognitive outcomes, and our understanding of early influences on brain development and function.

Visual attentional orienting by eye gaze: A meta-analytic review of the gaze-cueing effect.

Given limitations in the amount of visual information that a person can simultaneously process through to conscious perception, selective visual attention is necessary. Visual signals in the environment aid this selection process by triggering reflexive shifts of covert attention to locations of potential importance. One such signal appears to be others' eye gaze. Indeed, a gaze-cueing effect, whereby healthy adults respond faster to targets that are presented at locations cued rather than miscued by eye gaze has been consistently observed in the empirical literature. Critically though, the influences of task and cue features on this effect are not well understood. To address this gap, we report a meta-analytic integration of 423 gaze-cueing effects using a multilevel approach. A gaze-cueing effect emerged across all levels of the assessed task and cue features, indicating that others' eye gaze reliably directs observers' attention. We found that the magnitude of the gaze-cueing effect was moderated by whether direct gaze cues preceded directional gaze cues or not; the cue-target stimulus onset asynchrony (SOA), whether participants had to detect, localize, or categorize targets; and the cue's facial expression. Whether or not the gaze cue remained on screen after the target appeared, and whether schematic faces, computer-generated faces, or images of real faces were used as cues, did not appear to reliably function as moderators. The theoretical implications of these findings are discussed, particularly in relation to the social attention system. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Task characteristics influence facial emotion recognition age-effects: A meta-analytic review.

Relative to their young counterparts, older adults are poorer at recognizing facial expressions. A 2008 meta-analysis of 17 facial emotion recognition data sets showed that these age-related difficulties are not uniform. Rather, they are greatest for the emotions of anger, fear, and sadness, comparative with happiness and surprise, with no age-effect found for disgust. Since then, there have been many methodological advances in assessing emotion recognition. The current comprehensive meta-analysis systematically tested the influence of task characteristics (e.g., photographs vs. videos). The meta-analysis included 102 data sets that compared facial emotion recognition in older and young adult samples (N = 10,526). With task type combined, the pattern of age-effects across emotions was mostly consistent with the previous meta-analysis (i.e., largest age-effects for anger, fear, sadness; no effect for disgust). However, the magnitude and direction of age-effects were strongly influenced by elements of task design. Specifically, videos produced relatively moderate age-effects across all emotions, which indicates that older adults may not exhibit a positivity effect for facial emotion recognition. For disgust recognition, older adults demonstrated superior accuracy to young adults for the most common image set (Pictures of Facial Affect). However, they were poorer than young adults at recognizing this emotion for all other stimulus formats and image sets, which suggests that they do not retain disgust recognition. We discuss the implications that such diversity in the age-effects produced by different facial emotion recognition task designs has for understanding real-world deficits and task selection in future emotion recognition studies. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Visual attention, biological motion perception, and healthy ageing.

Biological motion perception is the ability of the visual system to perceive complex human movement patterns. The previous studies have shown a direct link between attentional abilities and performance on biological motion tasks, both of which have been shown to deteriorate with age. However, it is not known whether there is a direct link between age-related deficits in biological motion processing and attention. Here, we investigated whether age-related changes in biological motion perception are mediated by impaired attentional abilities. To assess basic biological motion performance, we asked 42 younger (M = 21 years) and 39 older adults (M = 69 years) to indicate the facing direction of point-light actions. Performance did not differ between age groups. We assessed visual spatial and selective attentional abilities, using a range of tasks: conjunctive visual search, spatial cueing, and the Stroop task. Across all tasks, older adults were significantly slower to respond and exhibited larger interference/cueing effects, compared to younger adults. To assess attentional demands in relation with biological motion perception, participants performed a biological motion search task for which they had to indicate the presence of a target point-light walker among a varied number of distracters. Older adults were slower, and generally worse than younger adults at discriminating the walkers. Correlations showed that there was no significant relationship between performance in attention tasks and biological motion processing, which indicates that age-related changes in biological motion perception are unlikely to be driven by general attentional decline.

The nature of anger in people with multiple sclerosis: a qualitative study.

Objective: People with multiple sclerosis (pwMS) who experience higher levels of anger also report poorer quality of life (QoL). This qualitative study explored the subjective experience of anger amongst pwMS, and how anger influenced their lives.Methods: A series of semi-structured, face-to-face interviews were conducted with 20 pwMS. Interviews were recorded, transcribed and then Interpretative Phenomenological Analysis was used to analyse the emerging themes.Results: The most common experience of anger was frustration that MS-related symptoms restricted participation in everyday activities. Also, some experiences of anger-with-self were focused on frustration at the inability to overcome symptom-related activity limitations. Participants reported frustration with others' insensitivity to the effects of the disease process, as well as usual daily irritations with family and colleagues. Some of the participants reported the use of coping strategies to deal with anger episodes.Conclusion: Many pwMS experience frustration at the restrictions that the disease places on them, self-directed anger, and irritation with others' attitude towards them. Much research in MS focuses on physical symptoms, but current results indicate that there is a need to better understand the emotional challenges faces by pwMS, and to provide more support for those who are experiencing frustration.

Age-related differences in the ability to decode intentions from non-literal language.

Older adults sometimes experience difficulty in decoding non-literal language, such as sarcastic statements where the underlying meaning differs from the literal words used. Given that sarcasm usually communicates a negative message this age effect might be explained by a positivity bias in old age. Here we test this for the first time by looking at age differences in interpreting non-literal compliments made with positive intention. However, another possibility is that older adults may fail to interpret such remarks correctly because these non-literal compliments are rarely encountered in everyday interactions. The aim of this study was therefore to compare younger and older adults' comprehension of positively and negatively valenced non-literal language. Forty younger and thirty-eight older adults read short story scenarios ending with a positive or negative, literal or non-literal evaluative appraisal of an event. Older adults were less likely than young to detect negatively valenced non-literal criticism and there were even more pronounced age-related differences in comprehending positive non-literal compliments. This indicates that age differences in understanding non-literal language are not driven by positivity biases. The relative rarity of non-literal compliments may have made these particularly difficult to interpret for both younger and older adults. Younger adults' performance indicated that non-literal language mutes perceived levels of critique and praise, while older adults' tendency to misinterpret non-literal language means that they may not benefit from this muting function. Potential implications for social interactions in older adulthood are discussed.

Correction: Imprinting methylation in SNRPN and MEST1 in adult blood predicts cognitive ability.

[This corrects the article DOI: 10.1371/journal.pone.0211799.].

Imprinting methylation in SNRPN and MEST1 in adult blood predicts cognitive ability.

Genomic imprinting is important for normal brain development and aberrant imprinting has been associated with impaired cognition. We studied the imprinting status in selected imprints (H19, IGF2, SNRPN, PEG3, MEST1, NESPAS, KvDMR, IG-DMR and ZAC1) by pyrosequencing in blood samples from longitudinal cohorts born in 1936 (n = 485) and 1921 (n = 223), and anterior hippocampus, posterior hippocampus, periventricular white matter, and thalamus from brains donated to the Aberdeen Brain Bank (n = 4). MEST1 imprint methylation was related to childhood cognitive ability score (-0.416 95% CI -0.792,-0.041; p = 0.030), with the strongest effect evident in males (-0.929 95% CI -1.531,-0.326; p = 0.003). SNRPN imprint methylation was also related to childhood cognitive ability (+0.335 95%CI 0.008,0.663; p = 0.045). A significant association was also observed for SNRPN methylation and adult crystallised cognitive ability (+0.262 95%CI 0.007,0.517; p = 0.044). Further testing of significant findings in a second cohort from the same region, but born in 1921, resulted in similar effect sizes and greater significance when the cohorts were combined (MEST1; -0.371 95% CI -0.677,-0.065; p = 0.017; SNRPN; +0.361 95% CI 0.079,0.643; p = 0.012). For SNRPN and MEST1 and four other imprints the methylation levels in blood and in the five brain regions were similar. Methylation of the paternally expressed, maternally methylated genes SNRPN and MEST1 in adult blood was associated with cognitive ability in childhood. This is consistent with the known importance of the SNRPN containing 15q11-q13 and the MEST1 containing 7q31-34 regions in cognitive function. These findings, and their sex specific nature in MEST1, point to new mechanisms through which complex phenotypes such as cognitive ability may be inherited. These mechanisms are potentially relevant to both the heritable and non-heritable components of cognitive ability. The process of epigenetic imprinting-within SNRPN and MEST1 in particular-and the factors that influence it, are worthy of further study in relation to the determinants of cognitive ability.

Effects of induced sad mood on facial emotion perception in young and older adults.

Older adults perceive less intense negative emotion in facial expressions compared to younger counterparts. Prior research has also demonstrated that mood alters facial emotion perception. Nevertheless, there is little evidence which evaluates the interactive effects of age and mood on emotion perception. This study investigated the effects of sad mood on younger and older adults' perception of emotional and neutral faces. Participants rated the intensity of stimuli while listening to sad music and in silence. Measures of mood were administered. Younger and older participants' rated sad faces as displaying stronger sadness when they experienced sad mood. While younger participants showed no influence of sad mood on happiness ratings of happy faces, older adults rated happy faces as conveying less happiness when they experienced sad mood. This study demonstrates how emotion perception can change when a controlled mood induction procedure is applied to alter mood in young and older participants.

The role of social attention in older adults' ability to interpret naturalistic social scenes.

Age-related differences on theory of mind (ToM) tasks are well established. However, the literature has been criticised for predominantly relying on tasks with poor ecological validity, and consequently it remains unclear whether these age differences extend to tasks with greater realism. In addition, we currently have a limited understanding of the factors that may contribute to age-related declines in ToM. To address these issues, we conducted two studies that assessed age differences in ToM using multimodal social scene stimuli. Study 1 also examined eye movements to assess whether biases in visual attention may be related to age-related difficulties in ToM, and Study 2 included an assessment of social attention (as indexed by biological motion perception) and working memory to assess whether these capacities may explain age difficulties in ToM. In both studies, the results showed that older adults performed worse than their younger counterparts on the ToM tasks, indicating that age-related difficulties in ToM extend to measures that more closely represent everyday social interactions. The eye-tracking data in Study 1 showed that older adults gazed less at the faces of protagonists in the social scenes compared with younger adults; however, these visual biases were not associated with ToM ability. Study 2 showed that older age was associated with a reduced ability to detect biological motion cues, and this mediated age-related variance in ToM ability. These findings are discussed in relation to competing theoretical frameworks of ageing that predict either improvements or declines in ToM with age.

Theory of Mind and Executive Functioning Following Stroke.

OBJECTIVE: Cognitive deficits following stroke are well documented, but less is known about problems with social skills such as understanding others' thoughts and feelings. This study investigated the effect of stroke on a visual-affective measure of social understanding: the Reading the Mind in the Eyes test (RMET). The aims were to investigate whether right hemisphere stroke was particularly detrimental to this aspect of Theory of Mind (ToM), and investigate the relationship between ToM ability and executive function following stroke. METHODS: Performance of stroke patients (right hemisphere stroke, n = 15; left hemisphere stroke, n = 15) was compared to that of controls (n = 40) matched for age, years of education, and IQ on tasks measuring ToM and executive functioning. RESULTS: Right hemisphere stroke was associated with impaired ToM ability, but left hemisphere stroke was not. There was no effect of stroke on a matched non-ToM control task. High correlations were found between performance on the RMET and some measures of executive functioning in participants with right hemisphere stroke only. Further analyses suggested that deficits in executive functioning could not statistically explain all of the difficulties shown by stroke participants on the RMET. CONCLUSIONS: A reduction in the ability to attribute mental states to others following right hemisphere stroke may adversely affect psychosocial functioning, disrupt interpersonal relationships, and lead to reduced quality of life. The clinical importance of these findings, implications for clinical practice and future research are discussed.

Gaze detection and gaze cuing in Alzheimer's disease.

People with Alzheimer's disease (AD) show problems with social processing in tasks which require the understanding of others' mental states. However traditional social processing tasks are cognitively complex, which may influence the effects of AD. Less is known about how AD influences more basic aspects of social perception, such as the ability to decode eye gaze direction or follow the gaze of another. The current research assessed whether those with AD showed difficulty in both explicitly decoding subtle manipulations of gaze direction (Study 1), and reflexively following another's eye gaze (Study 2). Those with AD were more impaired than a matched control group when making explicit discrimination distinctions between direct and averted gaze. In contrast people with Alzheimer's disease performed comparably to a control group when following gaze. This pattern indicates that more automatic aspects of social perception such as gaze following are unaffected by AD. In contrast, more controlled processes such as deciding whether someone is looking towards you are impaired in AD. This has implications for socially engaging with other people and interpreting their focus of interest.

Effect of Different Types of Physical Activity on Activities of Daily Living in Older Adults: Systematic Review and Meta-Analysis.

Physical activity is associated with greater independence in old age. However, little is known about the effect of physical activity level and activity type on activities of daily living (ADL). This review systematically analyzed the effects of physical activity level and activity type on ADL in older adults (mean age, 60+). Electronic search methods (up to March 2015) identified 47 relevant, randomized controlled trials. Random effects meta-analyses revealed significant, beneficial effects of physical activity on ADL physical performance (SMD = 0.72, 95% CI [0.45, 1.00]; p < .01), with the largest effects found for moderate physical activity levels, and for activity types with high levels of mental (e.g., memory, attention), physical (e.g., coordination, balance) and social (e.g., social interaction) demands. Inconsistent effects were observed on self-reported ADL measures. Interventions that include moderate physical activity levels with high mental, physical, and social demands may produce the greatest benefits on ADL physical performance.

Age Deficits in Facial Affect Recognition: The Influence of Dynamic Cues.

OBJECTIVES: Older adults have difficulties in identifying most facial expressions of emotion. However, most aging studies have presented static photographs of intense expressions, whereas in everyday experience people see emotions that develop and change. The present study was designed to assess whether age-related difficulties with emotion recognition are reduced when more ecologically valid (i.e., dynamic) stimuli are used. METHOD: We examined the effect of stimuli format (i.e., static vs. dynamic) on facial affect recognition in two separate studies that included independent samples and distinct stimuli sets. In addition to younger and older participants, a middle-aged group was included in Study 1 and eye gaze patterns were assessed in Study 2. RESULTS: Across both studies, older adults performed worse than younger adults on measures of facial affect recognition. In Study 1, older and-middle aged adults benefited from dynamic stimuli, but only when the emotional displays were subtle. Younger adults gazed more at the eye region of the face relative to older adults (Study 2), but dynamic presentation increased attention towards the eye region for younger adults only. DISCUSSION: Together, these studies provide important and novel insights into the specific circumstances in which older adults may be expected to experience difficulties in perceiving facial emotions.