RESUMEN
Objective: Abdominal aortic aneurysm (AAA) is a serious illness occurring in 1 of 20 older men. Guidelines emphasize the role of ultrasound scanning for patients at risk of AAA, yet the cost effectiveness of such scanning remains uncertain. New pocket mobile echocardiography (PME) devices may enhance the cost effectiveness of such scanning due to its low cost, ability to be used in primary care settings, and high degree of accuracy. This study performs cost utility analyses (CUAs) comparing opportunistic scanning for AAA using a PME to usual care for a hypothetical cohort of 10,000 male smokers age 65+. Methods: The study compares the incremental cost per quality-adjusted life year (QALY) gained for three alternative strategies over a 5-year time horizon. The study used a decision analytic simulation model to calculate the incremental cost utility for the different strategies. Three alternative criteria for surgical intervention were considered via scanning according to aneurysm size. These treatment strategies were compared to a control group that received no scanning. Model input values are taken from the literature. Sensitivity analysis was performed to gauge the robustness of the results. Results: Opportunistic scanning is cost effective. Indeed, when surgical intervention is limited to medium (5.0-5.4 cm) or large (≥5.5 cm) aneurysms, such scanning is dominant; that is, it costs less and increases QALYs compared to usual care. When surgical intervention is extended to small (4.0-4.9 cm) aneurysms, scanning remains cost effective ($64,156 per QALY vs. $100,000 threshold). The results are robust to alternative plausible model input values. Conclusion: These findings suggest that primary care physicians with proper training should consider PMEs as a cost effective method to opportunistically scan and manage AAA patients among older males who have a history of smoking.
RESUMEN
BACKGROUND: Biennial faecal occult blood testing (FOBT) for individuals aged 60-69 years is the primary screening tool for colorectal cancer (CRC) in the UK NHS, despite a large number of patients undergoing an unnecessary optical colonoscopy (OC) and evidence from modelling studies to suggest that more cost-effective technologies exist. CT colonography (CTC) is an emerging CRC screening technology with the potential to prevent CRC by detecting pre-cancerous polyps and to detect cancer at an earlier stage. OBJECTIVE: to assess the impact of introducing CTC into the UK NHS screening programme for CRC on key health outcomes as well as the NHS budget and healthcare resource capacity. METHODS: a discrete Markov model was used to reflect the natural history of CRC and the impact of three screening scenarios (biennial FOBT with and without CTC triage of patients referred to OC, and CTC every 5 years) on a range of health outcomes, including the incidence and prevalence of CRC, in a hypothetical cohort of individuals. The yearly costs, health outcomes and healthcare resource capacity requirements were estimated over a 10-year period (2009-18). RESULTS: using CTC to follow up FOBT-positive patients (scenario 2) was less costly than directing all FOBT-positive patients to OC (scenario 1); saving £776 283 over 10 years for 100 000 individuals invited for screening (year 2007 values), primarily by avoiding approximately 1700 OCs, but was estimated to require 2200 additional CT scans. Implementing a programme of 5-yearly CTC as a primary screen is expected to be more expensive than FOBT screening over the short term (driven by high screening and diagnosis costs), despite substantial savings in treatment costs for CRC over the 10-year time horizon of the model and improved health outcomes. CONCLUSIONS: adding CTC into the existing NHS Bowel Cancer Screening Programme as part of a preventive screening strategy could be less costly to the NHS over the longer term when used to triage FOBT-positive patients to appropriate follow-up. Increased demand for radiology services may be compensated for by reduced demand in endoscopy units.
