1.
Genome Biol
; 7(5): 216, 2006.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16737556
RESUMEN
Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers.