RESUMEN
Previous studies evaluating short-term itraconazole and terbinafine therapy for onychomycosis have varied in protocol and size; this double-blind study enabled a large-scale, standardized, direct comparison. Patients with toenail onychomycosis were randomized to itraconazole 200 mg daily (n = 146) or terbinafine 250 mg daily (n = 146) for 12 weeks, with a 36-week follow-up. Mycological cure rates at the follow-up end-point were significantly equivalent (61% with itraconazole vs. 67% with terbinafine). A similar proportion of patients in each group experienced adverse events during treatment (itraconazole, 22%; terbinafine, 23%). More patients receiving terbinafine stopped treatment permanently because of treatment-related adverse events (8% vs. 1%).
Asunto(s)
Antifúngicos/uso terapéutico , Itraconazol/uso terapéutico , Naftalenos/uso terapéutico , Onicomicosis/tratamiento farmacológico , Dolor Abdominal/inducido químicamente , Adolescente , Adulto , Anciano , Antifúngicos/efectos adversos , Método Doble Ciego , Dispepsia/inducido químicamente , Femenino , Dermatosis del Pie/tratamiento farmacológico , Dermatosis del Pie/microbiología , Cefalea/inducido químicamente , Humanos , Itraconazol/efectos adversos , Masculino , Persona de Mediana Edad , Naftalenos/efectos adversos , Náusea/inducido químicamente , Trastornos del Gusto/inducido químicamente , Terbinafina , Resultado del Tratamiento , Trichophyton/efectos de los fármacos , Trichophyton/aislamiento & purificación , Virosis/inducido químicamenteRESUMEN
The case of a 21 years old female patient is reported who has had scaly lesions on the scalp since the age of 3, alopecia (later scarring alopecia) since the age of 5, and erythematous and squamous lesions on the trunk and limbs since the age of 14. More recently she developed grouped follicular papules on the trunk, back of the neck and upper limbs. Seven biopsies from the scalp, trunk and sole of foot were performed which showed typical psoriatic changes in all but one, from the scalp, where only scarring alopecia changes could be found. In one lesion from the trunk pseudogranulomatous features were observed in some papillae which were probably due to ectasia, tortuosity and endothelial proliferation of papillary blood vessels. The oral administration of RO 10-9359 was followed by a good remission of the lesions with exception of the scalp alopecia. The differential diagnosis, particularly with pityriasis rubra pilaris and lichen planus, is discussed and the similarities of our case with the Piccardi-Lassueur-Graham Little syndrome emphasised. If one accepts multiple diseases as the cause of the syndrome psoriasis could be admitted as one of them.
