1.
J Org Chem
; 88(14): 10027-10039, 2023 Jul 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37433107
RESUMEN
We have developed a direct method for the synthesis of polyring-fused imidazo[1,2-a]pyridines via a copper-catalyzed annulation of electrophilic benzannulated heterocycles with 2-aminopyridine and 2-aminoquinoline. From 3-nitroindoles and 2-aminopyridine, we could synthesize tetracenes, viz., indole-fused imidazo[1,2-a]pyridines, and by starting from 2-aminoquinoline, we could generate pentacenes, viz., indolo-imidazo[1,2-a]quinolines. In addition, we could also extend the methodology toward the synthesis of benzothieno-imidazo[1,2-a]pyridines starting from 3-nitrobenzothiophene. Furthermore, the basic photophysical properties of these synthesized heteroacenes were evaluated.