Asunto(s)
Calcinosis/patología , Lupus Eritematoso Sistémico/patología , Enfermedades de la Piel/patología , Adolescente , Biopsia con Aguja , Calcinosis/complicaciones , Femenino , Técnica del Anticuerpo Fluorescente Indirecta , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Lupus Eritematoso Sistémico/complicaciones , Mucosa Bucal/patología , Enfermedades Raras , Medición de Riesgo , Índice de Severidad de la Enfermedad , Enfermedades de la Piel/complicaciones , Lengua/patologíaRESUMEN
A 64-year-old woman experienced progressive generalized poikiloderma after an episode of sunburn 4 years earlier. The diagnosis of subacute cutaneous lupus erythematosus (SCLE) was confirmed by the presence of anti-Ro/SS-A and antinuclear antibodies, the histology, and the direct immunofluorescent findings (ie, positive lupus band test and "dust-like" epidermal IgG staining pattern). Poikiloderma has not been previously reported in the spectrum of SCLE. As a major pathomechanism of SCLE, photosensitivity might explain this uncommon clinical manifestation of the disease.
Asunto(s)
Lupus Eritematoso Cutáneo/patología , Síndrome Rothmund-Thomson/patología , Dermatitis Fotoalérgica , Diagnóstico Diferencial , Femenino , Humanos , Lupus Eritematoso Cutáneo/diagnóstico , Persona de Mediana Edad , Síndrome Rothmund-Thomson/diagnóstico , Quemadura SolarRESUMEN
Down syndrome is associated with an increased incidence of cutaneous manifestations such as atopic dermatitis, alopecia areata, elastosis perforans serpiginosa, syringomas, and skin infections. We describe 3 patients with Down syndrome: an 8-year-old boy with alopecia areata, a 17-year-old boy with crusted scabies, and a 39-year-old woman with a cutaneous collagen vascular disease-like disorder. We also review cutaneous signs of this syndrome.
Asunto(s)
Alopecia Areata/diagnóstico , Enfermedades del Colágeno/diagnóstico , Síndrome de Down/diagnóstico , Exantema/diagnóstico , Escabiosis/diagnóstico , Adolescente , Adulto , Alopecia Areata/complicaciones , Alopecia Areata/terapia , Biopsia , Niño , Enfermedades del Colágeno/complicaciones , Enfermedades del Colágeno/patología , Síndrome de Down/complicaciones , Exantema/complicaciones , Exantema/patología , Femenino , Humanos , Masculino , Escabiosis/complicaciones , Escabiosis/patología , Escabiosis/terapia , Piel/parasitología , Piel/patologíaAsunto(s)
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Lupus Eritematoso Sistémico/inducido químicamente , Antígenos Nucleares , Proteínas de Unión al ADN/efectos de los fármacos , Proteínas de Unión al ADN/metabolismo , Femenino , Humanos , Lupus Eritematoso Sistémico/patología , Lupus Eritematoso Sistémico/terapia , Masculino , Proteínas Nucleares/efectos de los fármacos , Proteínas Nucleares/metabolismo , Preparaciones Farmacéuticas/metabolismo , PronósticoAsunto(s)
Dermatosis Facial/patología , Lupus Eritematoso Sistémico/patología , Adulto , Dapsona/uso terapéutico , Quimioterapia Combinada , Dermatosis Facial/tratamiento farmacológico , Femenino , Técnica del Anticuerpo Fluorescente Indirecta , Humanos , Lupus Eritematoso Sistémico/diagnóstico , Lupus Eritematoso Sistémico/tratamiento farmacológico , Metilprednisolona/uso terapéutico , Enfermedades Cutáneas Vesiculoampollosas/patologíaAsunto(s)
Lupus Vulgar/complicaciones , Lupus Vulgar/patología , Tuberculosis Cutánea/complicaciones , Tuberculosis Cutánea/patología , Anciano , Dermatosis del Pie/complicaciones , Dermatosis del Pie/patología , Humanos , Hiperplasia , Masculino , Enfermedades de la Uña/complicaciones , Enfermedades de la Uña/patología , Cuello/patología , NecrosisRESUMEN
Chronic mucocutaneous candidosis has been described in patients with impaired cell-mediated immunity. We describe a female patient with sarcoidosis who developed a Candida granuloma on her upper lip. Moderate impairment of the cell-mediated immunity was detected. Three months' treatment with ketoconazole was successful, but the lesion recurred at the same place after treatment was stopped.
Asunto(s)
Candidiasis Cutánea/complicaciones , Candidiasis Bucal/complicaciones , Boca/microbiología , Sarcoidosis/complicaciones , Candidiasis Cutánea/microbiología , Candidiasis Bucal/microbiología , Femenino , Humanos , Labio/microbiología , Labio/patología , Boca/patología , Mucosa Bucal/microbiología , Prednisolona/uso terapéutico , Sarcoidosis/terapiaAsunto(s)
Amiloidosis/patología , Enfermedades Cutáneas Vesiculoampollosas/patología , Administración Cutánea , Amiloidosis/tratamiento farmacológico , Colchicina/uso terapéutico , Dimetilsulfóxido/administración & dosificación , Dimetilsulfóxido/uso terapéutico , Femenino , Dermatosis de la Mano/tratamiento farmacológico , Dermatosis de la Mano/patología , Humanos , Persona de Mediana Edad , Enfermedades Cutáneas Vesiculoampollosas/tratamiento farmacológicoRESUMEN
We report on a 23-year-old white Cuban suffering from congenital dyskeratosis. In addition to the obligatory triad of poikilodermia, onychodystrophy, and leukoplakia, the patient showed congenital stenosis of the esophagus and extreme seborrhea of the scalp.
Asunto(s)
Leucoplasia Bucal/genética , Uñas Malformadas/genética , Síndrome Rothmund-Thomson/genética , Enfermedades de la Piel/genética , Neoplasias de la Lengua/genética , Adulto , Consanguinidad , Humanos , Masculino , SíndromeRESUMEN
A 16-year-old girl initially had an eruption consisting of dark gray, flat, pin-sized, confluent papules with a slight hyperkeratotic surface. The lesions appeared after her summer holidays and were restricted to the tanned skin of sun-exposed areas, mainly the abdomen and back. Clinical and histologic findings were consistent with confluent and reticulated papillomatosis. If a basic disorder of keratinization is the cause of confluent and reticulated papillomatosis, it seems likely that the development of the disease in our patient may be due to an abnormal epidermal response to ultraviolet light.
Asunto(s)
Trastornos de la Pigmentación/patología , Rayos Ultravioleta/efectos adversos , Adolescente , Biopsia , Epidermis/patología , Femenino , Humanos , Papiloma/patología , Trastornos de la Pigmentación/tratamiento farmacológico , Tretinoina/uso terapéuticoRESUMEN
Two patients with idiopathic generalized livedo reticularis and associated cerebrovascular disease are reported. In one of the cases (case no. 1) skin vascular lesions were present in two members of the family, thus suggesting the existence of a possible predisposition to systemic vascular affection. The need of prevention of the neurological symptoms in patients with generalized livedo reticularis, through the exclusion of the nocive agents which can cause vascular damage is emphasized.
Asunto(s)
Trastornos Cerebrovasculares/complicaciones , Enfermedades de la Piel/etiología , Enfermedades Vasculares/patología , Adulto , Familia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Piel/irrigación sanguínea , Síndrome , Muslo , Enfermedades Vasculares/complicacionesRESUMEN
A 62-year-old male subject has developed carcinoma cuniculatum on the sole. The authors consider that the physician should bear in mind the possibility of a diagnostic error when selecting the therapeutic method. They suppose that carcinoma cuniculatum should be referred to verruciform carcinomas.
Asunto(s)
Carcinoma de Células Escamosas/patología , Enfermedades del Pie/patología , Neoplasias Cutáneas/patología , Biopsia , Pie/patología , Humanos , Masculino , Persona de Mediana Edad , Piel/patologíaRESUMEN
We report on a 38-year-old male patient suffering from pachydermoperiostosis (Touraine-Solente-Golé Syndrome), who underwent a cosmetic operation without success.
Asunto(s)
Huesos/diagnóstico por imagen , Osteoartropatía Hipertrófica Primaria/diagnóstico por imagen , Adulto , Cara/cirugía , Humanos , Masculino , Radiografía , Cirugía PlásticaRESUMEN
We report on two patients (father and son) suffering from familial Lupus erythematosus chronicus discoides which could be proved clinically, histologically, and immunologically. Investigations on HLA revealed A-11, A-24, and B-35 for the father and A-24, B-13, and C-4 for the son.
Asunto(s)
Dermatosis Facial/genética , Lupus Eritematoso Discoide/genética , Adulto , Niño , Dermatosis Facial/patología , Técnica del Anticuerpo Fluorescente , Antígenos HLA/genética , Humanos , Inmunoglobulina G/metabolismo , Inmunoglobulina M/metabolismo , Lupus Eritematoso Discoide/patología , Piel/patologíaRESUMEN
A patient with well-defined erythematous lesions with some atrophy on the scalp and face and lichen planus papules on the limbs and sacral region is reported. The histopathological features and the deposits of immunoglobulins in the cutaneous lesions confirm the presence of both diseases. The difficulties of the differential diagnosis are due to the interaction between lupus erythematosus chronicus discoides and lichen planus probably occurring in the same patient.
Asunto(s)
Liquen Plano/complicaciones , Lupus Eritematoso Discoide/complicaciones , Diagnóstico Diferencial , Femenino , Humanos , Inmunoglobulina G/inmunología , Inmunoglobulina M/inmunología , Liquen Plano/diagnóstico , Lupus Eritematoso Discoide/diagnóstico , Lupus Eritematoso Discoide/inmunología , Lupus Eritematoso Discoide/patología , Persona de Mediana EdadRESUMEN
An information is given about a 40 years old patient with a clinical picture of sclerodermia nodularis. A clinical and a histological diagnosis between sclerodermia nodularis and keloid is made.