1.
Org Lett
; 25(31): 5902-5906, 2023 Aug 11.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37530221
RESUMEN
Substituted allyl derivatives with an internal double bond can be homologated under standard conditions via a 1,2-shift, whereas allylboronic esters with terminal double bonds can also be homologated via a SN' reaction. This allyl isomerization is catalyzed by ZnCl2 and can be suppressed by omitting ZnCl2 during the formation of α-chloroboronic ester. However, in the second step with Grignard reagents, ZnCl2 was added to suppress side reactions of the product formed.