[Energy expenditures in patients with insulin-dependent diabetes mellitus in a hospital and ambulatory environment (computer analysis)]. / Energotraty u bol'nykh insulinzavisimym sakharnym diabetom v statsionarnykh i ambulatornykh usloviiakh (komp'iuternyi analiz).

Original computer programs for assessment of energetic value of nutrition and daily energy expenditures of man based on physical activity protocols have been developed. The programs were tried in 16 patients with insulin-dependent diabetes, and essential individual differences from tentative table estimations of energy expenditures were detected. Correlations between treatment efficacy and individual energy expenditures of patients were observed; a moderate deficit of nutrition calories was found more detrimental for metabolic control than their moderate excess. The regularities detected even in such a nonrepresentative sample permit us evaluate high the potentialities and significance of the suggested method for assessment of energy expenditures.

[Pharmacokinetics and pharmacodynamics of thiopental sodium in pregnant women during cesarean section]. / Farmakokinetika i farmakodinamika tiopental-natriia u beremennykh zhenshchin pri operatsii kesareva secheniia.

Comparative study of thiopental pharmacokinetics and hemodynamics has been conducted in two groups of pregnant women subjected to planned cesarean section. Group I consisted of 6 women (thiopental dose 8.0 mg/kg was combined with components of neuroleptanalgesia), group II consisted of 7 women (the drug dose 4.68 mg/kg was combined with moradol analgesia). Dose-dependent differences in pharmacokinetic regularities of sodium thiopental in the groups compared have been revealed. Moradol did not cause the drug accumulation in the bodies of mother and fetus. The higher Apgar score was characteristic of the newborns from group II. Adequate anesthesia in pregnant women from group II was due to the potentiating effect of moradol. In both groups a correlation has been established between pharmacokinetic parameters and hemodynamic changes, as well as between sodium thiopental concentration in maternal and umbilical blood and pharmacokinetic parameters.

[The pharmacokinetic and pharmacodynamic characteristics of moradol in parturients during obstetrical analgesia]. / Osobennosti farmakokinetiki i farmakodinamiki moradola u rozhenits na protiazhenii obezbolivaniia rodov.

Pharmacokinetic and pharmacodynamic monitoring of moradol (2 mg) given to 16 somatically healthy parturients during analgesia of spontaneous labor has identified 2 groups of patients who significantly differed in kinetic characteristics and in the drug's ability to penetrate through the placenta barrier. At the same time there were no significant differences in autonomic nervous function and central hemodynamics after intravenous moradol analgesia. The newborns from the two groups had identical high scores (8-9). Moradol produced an adequate analgesic effects in all parturients, reaching its peak at min 30-45 and lasting up to 2 hours. There was a high correlation between the plasma drug concentration and pharmacodynamic indices in parturients.

[The choice of anesthesia during abdominal delivery in patients with severe forms of late pregnancy toxemias]. / Vybor anestezii pri abdominal'nom rodorazreshenii u bol'nykh s tiazhelymi formami pozdnego toksikoza beremennykh.

Sixty eight anesthesia procedures during abdominal delivery in patients with late toxemia of pregnancy have been analysed. In 32 cases the diagnosis was preeclampsia, in 8 cases--eclampsia, in 28 cases III degree nephropathy. Depending on the variant and method of anesthesia the subjects were divided into 3 clinical groups. Group I comprised 31 women to whom cesarean section was performed under general endotracheal anesthesia. In group II (24 pregnant women) analgesia was achieved by prolonged epidural anesthesia (PEA). In group III (13 patients) a combination of PEA and superficial endotracheal anesthesia was used. Analysis of the anesthesia techniques in patients with severe late toxemia of pregnancy has established that in endotracheal anesthesia it is sometimes impossible to block completely pathological and operation-induced nociceptive pulsation. PEA has a good analgetic effect but ensures no neuroautonomous protection, and upon discontinuation of action of the local anesthetic there is a danger of the onset of the convulsion syndrome and signs of preeclampsia or eclampsia. Taking into account the advantages and disadvantages of endotracheal anesthesia and PEA, a technique based on the combination of both variants has been selected, which ensures optimal anesthesiological protection in abdominal delivery.

[The validation of the use of Moradol for anesthesia in spontaneous labor]. / Obosnovanie primeneniia moradola dlia obezbolivaniia samoproizvol'nykh rodov.

Pharmacodynamic and pharmacokinetic peculiarities of moradol have been studied during natural delivery. It has been shown that moradol injected both intramuscularly and intravenously in the first period of labour did not inhibit the circulation in the women in labour, had no impact on the course of labour and had no negative effect on the newborn. The use of moradol is recommended for analgesia of natural delivery. A correlation has been established between blood drug concentration and its pharmacodynamic indexes in women.

[Endometrial steroid receptor levels in habitual abortion in advanced pregnancy]. / Soderzhanie steroidnykh retseptorov v éndometrii pri privychnom nevynashivanii beremennosti pozdnikh srokov.

Estrogen and progesterone reception was examined in the endometrial cytoplasmic and nuclear fraction from apparently healthy subjects and patients with habitual late incompetent pregnancy in the early proliferative and late secretory periods of a menstrual cycle. The reception of the two reproductive hormones in the nuclei and the binding of estrogens in the endometrial cytosol were demonstrated to be significantly higher in the female patients than in healthy subjects. The cytosol estrogen to progesterone reception ratio was increased in the patients in the secretory phase of a menstrual cycle than in normal females. There was a complete normalization of endometrial reproductive hormone receptor levels in the patients undergoing hyperbaric oxygenation.

[State of the sex hormone receptor in the endometrium of women with late habitual abortion]. / Sostoianie retseptornogo apparata polovykh gormonov v éndometrii zhenshchin pri privychnom nevynashivanii beremennosti pozdnikh srokov.

A study was made of estrogen and progesterone reception of the endometrial cytoplasmatic and nuclear fractions of healthy women and women suffering from late habitual abortion in the early proliferative and late secretory phases of the menstrual cycle. Reception of both sex hormones in the nuclei and estrogen binding in the endometrial cytosol of women with late habitual abortion was significantly higher than that in healthy women. The estrogen receptors/progesterone receptors ratio in the cytosol in the pathological endometrium at the secretory phase of the menstrual cycle was higher than in the normal one. Hyperbaric therapy given to such patients resulted in complete normalization of endometrial sex hormones reception.

[Changes in the biochemical indices of parturients with uterine inertia against the background of therapy]. / Izmeneniia biokhimicheskikh pokazatelei u rozhenits so slabost'iu rodovoi deiatel'nosti na fone terapii.

A comparison was made of some biochemical parameters for energy metabolism, acid-base balance, blood gases and uterine contractility in parturients with uterine inertia who were on therapy with or without hyperbaric oxygenation. The presence of hypoxemia and metabolic acidosis in the parturients was found to intensify the processes of lipid peroxidation, to affect the functional status of myometrial biomembranes, to result in hyperenzymemia and disturbed tissue metabolism and lower myometrial contractility. The use of hyperbaric oxygenation in the multimodality therapy for uterine inertia was ascertained to eliminate oxygen deficiency, to increase tissue respiration, contributing to normal labor.

[Placental scintigraphy--a diagnostic method for evaluating indications for hyperbaric oxygenation in pregnant women with high risk of perinatal pathology]. / Stsintigrafiia platsenty--diagnosticheskii metod, pozvoliaiushchii opredeli't pokazaniia k giperbaricheskoi oksigenatsii u beremennykh gruppy vysokogo riska perinata'lnoi patologii.

At most, 40 pregnant females at a high risk for fetal perinatal pathology underwent clinical investigation, ultrasonic scanning of the placenta, recording of the fetal electro- and phonocardiography, the evaluation of the placental levels of lactogen and estradiol and thermoresistant alkaline phosphatase changes of the values considered who were then treated with hyperbaric oxygenation (HBO) under the control of dynamic placental scintigraphy. Based on the placentographic findings, the authors distinguished from the whole of the risk-group the patients whose pattern of uteroplacental blood flow response to the treatment was beneficial and therefore the HBO treatment for fetoplacental insufficiency was advisable.

[Variants of intravenous anesthesia during artificial termination of pregnancy]. / Varianty vnutrivennoi anestezii pri iskusstvennom preryvanii beremennosti.

The use of anesthetics, analgesics and nootrops in various combinations has been analysed in 270 somatically healthy women during termination of pregnancy. The use of calipsol in combination with diazepam or pipolphen is recommended. A concomitant use of nootropil has a marked positive effect on the postanesthesia period, minimizing hallucinations. Adequate anesthesia is achieved by using a narcotic analgesic dipidalor in combination with N2O inhalation or reduced doses of calipsol or barbiturates.

[Effect of the hyperbaric oxygenation of animals and man on mitochondrial function in their tissues (based on EPR study data)]. / Vliianie giperbaricheskoi oksigenatsii zhivotnykh i cheloveka na sostianie mitokhondrii v ikh tkaniakh (po dannym EPR-issledovanii).

The ration of differential intensities of EPR signal of free endogenous radicals of semiquinone type and iron-sulfur proteins recorded at the temperature of liquid nitrogen in tissues (R index) is proposed as a criterion for estimation of changes in the functional state of mitochondria in human and animal tissues treated with hyperbaric oxygenation (HBO). The increase in R value was observed in hearts of intact mice and rabbits treated with HBO in near-toxic doses. This indicates a shift in mitochondria redox state towards oxidation. The above effect was not observed in mitochondria from intact zone of myocardium in animals with experimental infarction, and the numbers of mitochondria in the tissue increased after HBO. HBO treatment of women with pathological pregnancy leads to the decrease in R value for placental mitochondria.

[Dynamic biochemical indices of parturients with uterine inertia against a background of hyperbaric oxygen and drug treatment]. / Dinamika na biokhimichnite pokazateli pri rodilki s rodova slabost na fona na khiperbarno kislorodno i medikamentozno lechenie.

Acid-base balance, lactate dehydrogenase, creatine phosphokinase, hydroxybutyrate dehydrogenase, oxytocinase and the final products of peroxide oxygenation of lipids-malonate dialdehyde and antioxidant activity were studied on 60 parturients, divided into two groups as each group had 30 women. Hyperbaric oxygen treatment in combination with oxytocin was studied on uterine inertia. The control group consisted of 20 parturients with normal course of delivery.

[Changes in the amine oxidase activity of human serum during different types of anesthesia and hyperbaric oxygenation]. / Izmenenie aktivnosti aminoksidaz syvorotki krovi cheloveka pri nekotorykh vidakh anestezii i pri giperbaricheskoo oksigenatsii.

Some types of anesthesia, used usually in labor anesthesia (sodium hydroxybutyrate, lexir) or in abdominal delivery (neuroleptanesthesia, cetalar narcosis, electroanesthesia) did not affect distinctly the activity of amine oxidases in blood sera of women in labor and of fetus. In some groups of women in labor the neonates were found, blood serum of which exhibited high activity of diamine oxidase, not observed in normal state. A slight decrease in deamination of benzylamine (20%) and 4-nitrobenzylamine (30%) was observed in patients with gynecological diseases within 2 and 3 days after operations. If intestinal paresis developed in the patients within the postoperational period deamination of these substrates was decreased by 75-80% in blood sera. After 2-4 courses of hyperbaric oxygenation a slight but statistically distinct decrease (by 22-25%) in the rate of deamination of benzylamine and 4-nitrobenzylamine was found in blood sera of the patients.