RESUMEN
In normolipidaemic young rats the intraperitoneal administration of diazepam (10 mg/kg) induced a marked fall of the total serum lipids and total cholesterol. A dose of 5 mg/kg brought about an increase of HDL2 lipoprotein fraction and an elevation of the HDL2/HDL2.HDL3 ratio. Margarine administration elicited a significant augmentation of the total serum lipids and a reduction of the HDL2/HDL2.HDL3 ratio. The intraperitoneal injection of diazepam in margarine-treated rats brought about a decrease of total serum lipids and total cholesterol, (when compared to the margarine values), an obvious elevation of the HDL2 fraction and of HDL2/HDL2.HDL3 ratio. The LDL1 (beta) fraction was decreased. These data confirm our earlier findings which show that diazepam improves the HDL cholesterol/total cholesterol ratio.
Asunto(s)
Diazepam/farmacología , Lipoproteínas/sangre , Animales , Colesterol/sangre , Diazepam/administración & dosificación , Electroforesis en Gel de Poliacrilamida , Inyecciones Intraperitoneales , Lipoproteínas/aislamiento & purificación , Masculino , Ratas , Ratas EndogámicasRESUMEN
The authors examined biopsies of the interpleural lymph nodes harvested by mediastinoscopy and hilloscopy in 162 patients (133 males and 29 females). The diagnostic efficiency is very high in sarcoidosis, silicosis and in Hodgkin's disease. In sarcoidosis biopsy is able to indicate the evolutive stage of the disease. In malignant lymphogranulomatosis all the observations belonged to type II of nodular sclerosis. In bronchial carcinoma interpleural lymph node biopsy may be practised with diagnostic purposes or in order to check up operability.
