RESUMEN
Two thermoresponsive copolymers with different lower critical solution temperatures (LCSTs) were crosslinked using silica nanoparticles to afford hybrid hydrogels exhibiting two distinct thermo-responsivities. The thermo-responsive copolymers were synthesised by free radical polymerisation from a monomer with a reactive side chain (3-methacryloxypropyl trimethoxysilane (S)) and water-soluble monomers with different thermo-responsivities (N-isopropyl acrylamide (N) or N-(3-methoxy propyl)acrylamide (M)). The obtained reactive copolymers, poly(N-isopropyl acrylamide-co-3-methacryloxypropyl trimethoxysilane) (pNS) and poly(N-(3-methoxy propyl acrylamide-co-3-methacryloxypropyl trimethoxysilane)) (pMS), were characterized by multiple techniques including 1H NMR and FTIR spectroscopy. The hetero-network hybrid hydrogels were easily prepared by mixing aqueous solutions of the copolymer with an aqueous colloidal silica suspension; their gelation properties could be tuned by varying the amounts of pNS, pMS, and Si. Differential scanning calorimetric analysis showed that the hetero-network hydrogel exhibited a critical two-step phase transition at temperatures around the LCST of each copolymer (33 °C for pNS, 73 °C for pMS), indicating that each polymer does not disturb the phase transitions of the other. The deswelling of the hetero-network hydrogel could be controlled with respect to temperature and time.
