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An electrochemical nitrite sensor probe is introduced herein using a modified flat glassy carbon electrode (GCE) and SrTiO3 material doped with spherical-shaped gold nanoparticles (Au-NPs) and polypyrrole carbon (PPyC) at a pH of 7.0 in a phosphate buffer solution. The nanocomposites (NCs) containing Au-NPs, PPyC, and SrTiO3 were synthesized by ultrasonication, and their properties were thoroughly characterized through structural, elemental, optical, and morphological analyses with various conventional spectroscopic methods, such as field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, high-resolution transmission electron microscopy, powder X-ray diffraction, X-ray photoelectron spectroscopy, and Brunauer-Emmett-Teller method. The peak currents due to nitrite oxidation were characterized in detail and analyzed using conventional cyclic voltammetry (CV) as well as differential pulse voltammetry (DPV) under ambient conditions. The sensor response increased significantly from 0.15 to 1.5 mM of nitrite ions, and the sensor was fabricated by coating a conducting agent (PEDOT:PSS) on the GCE to obtain the Au-NPs/PPyC/SrTiO3 NCs/PEDOT:PSS/GCE probe. The sensor's sensitivity was determined as 0.5 µA/µMâcm2 from the ratio of the slope of the linear detection range by considering the active surface area (0.0316 cm2) of the flat GCE. In addition, the limit of detection was determined as 20.00 ± 1.00 µM, which was found to be satisfactory. The sensor's stability, pH optimization, and reliability were also evaluated in these analyses. Overall, the sensor results were found to be satisfactory. Real environmental samples were then analyzed to evaluate the sensor's reliability through DPV, and the results showed that the proposed novel electrochemical sensor holds great promise for mitigating water contamination in the real samples with the lab-made Au-NPs/PPyC/SrTiO3 NC. Thus, this study provides valuable insights for improving sensors for broad environmental monitoring applications using the electrochemical approach.
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The swift pace of socioeconomic development and climatic change have put significant strain on the quality of water resources. While, the bulk availability of agro-based materials arising from nature and agricultural practices has paved the way for researchers in eradicating toxic industrial pollutants such as dyes, heavy-metals, phenolic-compounds, pesticides, etc. by using them as adsorbents. In the area of pollution remediation, inventive technologies have been developing. The adsorption technique stands out among the other wastewater-treatment methods as it is simple, easy, efficient, and cost-effective. The agro-based adsorbents their use in this area contributes to minimizing natural waste. They can be employed in their original raw-form or after undergoing simple processes such as drying, grinding, and carbonization. Moreover, these adsorbents are typically modified physically or chemically to change their surface properties and improve their adsorption efficiency. The low-cost agro adsorbents have shown efficient adsorption capacities towards removing various organic and hazardous water pollutants. With a few exceptions, majority of adsorbents have demonstrated heavy metals, dyes and phenol removal efficiencies exceeding 90%. This review summarizes the available information and strategies for using agro-based adsorbents to eliminate hazardous water pollutants. It is a prospective area for research in the field of environmental pollution.
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MXenes (Mn+1XnTx), a subgroup of 2-dimensional (2D) materials, specifically comprise transition metal carbides, nitrides, and carbonitrides. They exhibit exceptional electrocatalytic and photocatalytic properties, making them well-suited for the detection and removal of pollutants from aqueous environments. Because of their high surface area and remarkable properties, they are being utilized in various applications, including catalysis, sensing, and adsorption, to combat pollution and mitigate its adverse effects. Different characterization techniques like XRD, SEM, TEM, UV-Visible spectroscopy, and Raman spectroscopy have been used for the structural elucidation of 2D MXene. Current responses against applied potential were measured during the electrochemical sensing of the hazardous pollutants in an aqueous system using a variety of electroanalytical techniques, including differential pulse voltammetry, amperometry, square wave anodic stripping voltammetry, etc. In this review, a comprehensive discussion on structural patterns, synthesis, properties of MXene and their application for electrochemical detection of lethal pollutants like hydroquionone, phenol, catechol, mercury and lead, etc. are presented. This review will be helpful to critically understand the methods of synthesis and application of MXenes for the removal of environmental pollutants.
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The global human population is growing and demand for food is increasing. Global agriculture faces numerous challenges, including excessive application of synthetic pesticides, emergence of herbicide-and pesticide-resistant pathogenic microbes, and more frequent natural disasters associated with global warming. Searches for valuable endophytes have increased, with the aim of making agriculture more sustainable and environmentally friendly. Endophytic microbes are known to have a variety of beneficial effects on plants. They can effectively transfer nutrients from the soil into plants, promote plant growth and development, increase disease resistance, increase stress tolerance, prevent herbivore feeding, reduce the virulence of pathogens, and inhibit the growth of rival plant species. Endophytic microbes can considerably minimize the need for agrochemicals, such as fertilizers, fungicides, bactericides, insecticides, and herbicides in the cultivation of crop plants. This review summarizes current knowledge on the roles of endophytes focusing on their mechanisms of disease control against phytopathogens through the secretion of antimicrobial substances and volatile organic compounds, and the induction of systemic resistance in plants. Additionally, the beneficial roles of these endophytes and their metabolites in the control of postharvest diseases in plants have been summarized.
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A poly(luminol-o-anisidine-o-toluidine) terpolymer was synthesized, characterized, and modified with GNPs and ZnO NPs. The nanocomposites were then examined for their electroactivity and potential use as cationic electrochemical sensors for detecting Sb3+ ions in phosphate buffer on the surface of a glassy carbon electrode (GCE). Among the different compositions and the terpolymer, the GCE adapted with the PLAT/ZnO/GNPs-5% nanocomposite displayed the highest current response. The fabricated nanocomposite sensor exhibited high sensitivity, with a value of 21.4177 µA µM-1 cm-2, and a low detection limit of 95.42 pM. The analytical performance of the sensor was evaluated over the linear dynamic range (LDR) of 0.1 nM to 0.01 mM. The proposed sensor is effective in detecting and measuring carcinogenic Sb3+ ions in real environmental samples using an electrochemical approach, making it a promising tool for environmental monitoring.
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Creating an innovative and environmentally friendly energy storage system is of vital importance due to the growing number of environmental problems and the fast exhaustion of fossil fuels. Energy storage using porous carbon composites generated from biomass has attracted a lot of attention in the research community. This is primarily due to the environmentally friendly nature, abundant availability in nature, accessibility, affordability, and long-term viability of macro/meso/microporous carbon sourced from a variety of biological materials. Extensive information on the design and the building of an energy storage device that uses supercapacitors was a part of this research. This study examines both porous carbon electrodes (ranging from 44 to 1050â F/g) and biomasses with a large surface area (between 215 and 3532â m2/g). Supposedly, these electrodes have a capacitive retention performance of about 99.7 percent after 1000 cycles. The energy density of symmetric supercapacitors is also considered, with values between 5.1 and 138.4â Wh/kg. In this review, we look at the basic structures of biomass and how they affect porous carbon synthesis. It also discusses the effects of different structured porous carbon materials on electrochemical performance and analyzes them. In recent developments, significant steps have been made across various fields including fuel cells, carbon capture, and the utilization of biomass-derived carbonaceous nanoparticles. Notably, our study delves into the innovative energy conversion and storage potentials inherent in these materials. This comprehensive investigation seeks to lay the foundation for forthcoming energy storage research endeavors by delineating the current advancements and anticipating potential challenges in fabricating porous carbon composites sourced from biomass.
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The C3-symmetry ionic polymer PPyTri has been designed with multi-walled carbon nanotubes (MWCNTs) or graphene nanoplatelets (GNPs) and studied as an ultrasensitive electrochemical sensor for trace Hg(II) detection. The synthesis approach incorporated attaching three pyridinium cationic components with chloride anions to the triazine core. The precursors, BPy, were synthesized using a condensation process involving 4-pyridine carboxaldehyde and focused nicotinic hydrazide. The polymer PPyTri was further modified with either MWCNTs or GNPs. The resulting ionic polymer PPyTri and its fabricated nanocomposites were characterized using infrared (IR), nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and powder X-ray diffraction (XRD). The analysis revealed that both the polymer and its nanocomposites have semi-crystalline structures. The electroactivity of the designed nanocomposites toward Hg + 2 ions revealed that among the nanocomposites and bare copolymer, the glassy carbon electrode (GCE) adapted with the PPyTri GNPs-5% exhibited the greatest current response over a wide range of Hg + 2 concentrations. The nanocomposite-modified electrode presented an excellent sensitivity of 83.33 µAµM - 1 cm - 2, a low detection limit of 0.033 nM, and a linear dynamic range of 0.1 nM to 0.01 mM (R2 = 0.9945).
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Today, textile-based wearable electronic devices (textronics) have been developed by taking advantage of nanotechnology and textile substrates. Textile substrates offer flexibility, air permeability, breathability, and wearability, whereas, using nanomaterials offers numerous functional properties, like electrical conductivity, hydrophobicity, touch sensitivity, self-healing properties, joule heating properties, and many more. For these reasons, textronics have been extensively used in many applications. Recently, new emerging two-dimensional (2D) transition metal carbide and nitride, known as MXene, nanomaterials have been highly considered for developing textronics because the surface functional groups and hydrophilicity of MXene nanoflakes allow the facile fabrication of MXene-based textronics. In addition, MXene nanosheets possess excellent electroconductivity and mechanical properties as well as large surface area, which also give numerous opportunities to develop novel functional MXene/textile-based wearable electronic devices. Therefore, this review summarizes the recent advancements in the architectural design of MXene-based textronics, like fiber, yarn, and fabric. Regarding the fabrication of MXene/textile composites, numerous factors affect the functional properties (e.g. fabric structure, MXene size, etc.). All the crucial affecting parameters, which should be chosen carefully during the fabrication process, are critically discussed here. Next, the recent applications of MXene-based textronics in supercapacitors, thermotherapy, and sensors are elaborately delineated. Finally, the existing challenges and future scopes associated with the development of MXene-based textronics are presented.
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Graphene quantum dot (GQD) integration into hydrogel matrices has become a viable approach for improving drug delivery and bioimaging in cancer treatment in recent years. Due to their distinct physicochemical characteristics, graphene quantum dots (GQDs) have attracted interest as adaptable nanomaterials for use in biomedicine. When incorporated into hydrogel frameworks, these nanomaterials exhibit enhanced stability, biocompatibility, and responsiveness to external stimuli. The synergistic pairing of hydrogels with GQDs has created new opportunities to tackle the problems related to drug delivery and bioimaging in cancer treatment. Bioimaging plays a pivotal role in the early detection and monitoring of cancer. GQD-based hydrogels, with their excellent photoluminescence properties, offer a superior platform for high-resolution imaging. The tunable fluorescence characteristics of GQDs enable real-time visualization of biological processes, facilitating the precise diagnosis and monitoring of cancer progression. Moreover, the drug delivery landscape has been significantly transformed by GQD-based hydrogels. Because hydrogels are porous, therapeutic compounds may be placed into them and released in a controlled environment. The large surface area and distinct interactions of graphene quantum dots (GQDs) with medicinal molecules boost loading capacity and release dynamics, ultimately improving therapeutic efficacy. Moreover, GQD-based hydrogels' stimulus-responsiveness allows for on-demand medication release, which minimizes adverse effects and improves therapeutic outcomes. The ability of GQD-based hydrogels to specifically target certain cancer cells makes them notable. Functionalizing GQDs with targeting ligands minimizes off-target effects and delivers therapeutic payloads to cancer cells selectively. Combined with imaging capabilities, this tailored drug delivery creates a theranostic platform for customized cancer treatment. In this study, the most recent advancements in the synergistic use of GQD-based hydrogels are reviewed, with particular attention to the potential revolution these materials might bring to the area of cancer theranostics.
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Antineoplásicos , Grafito , Hidrogeles , Neoplasias , Puntos Cuánticos , Hidrogeles/química , Puntos Cuánticos/química , Humanos , Grafito/química , Neoplasias/tratamiento farmacológico , Neoplasias/diagnóstico por imagen , Antineoplásicos/química , Antineoplásicos/farmacología , Sistemas de Liberación de Medicamentos , Animales , Imagen Óptica , Portadores de Fármacos/químicaRESUMEN
This review article provides a comprehensive overview of the advancements in using nanosuspensions for controlled drug delivery in ophthalmology. It highlights the significance of ophthalmic drug delivery due to the prevalence of eye diseases and delves into various aspects of this field. The article explores molecular mechanisms, drugs used, and physiological factors affecting drug absorption. It also addresses challenges in treating both anterior and posterior eye segments and investigates the role of mucus in obstructing micro- and nanosuspensions. Nanosuspensions are presented as a promising approach to enhance drug solubility and absorption, covering formulation, stability, properties, and functionalization. The review discusses the pros and cons of using nanosuspensions for ocular drug delivery and covers their structure, preparation, characterization, and applications. Several graphical representations illustrate their role in treating various eye conditions. Specific drug categories like anti-inflammatory drugs, antihistamines, glucocorticoids, and more are discussed in detail, with relevant studies. The article also addresses current challenges and future directions, emphasizing the need for improved nanosuspension stability and exploring potential technologies. Nanosuspensions have shown substantial potential in advancing ophthalmic drug delivery by enhancing solubility and absorption. This article is a valuable resource for researchers, clinicians, and pharmaceutical professionals in this field, offering insights into recent developments, challenges, and future prospects in nanosuspension use for ocular drug delivery.
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Administración Oftálmica , Sistemas de Liberación de Medicamentos , Oftalmopatías , Nanopartículas , Suspensiones , Humanos , Oftalmopatías/tratamiento farmacológico , Sistemas de Liberación de Medicamentos/métodos , Animales , Solubilidad , Oftalmología/métodosRESUMEN
Recent breakthroughs in the field of carbon nanotubes (CNTs) have opened up unprecedented opportunities for the development of specialized bioactive CNT-polymers for a variety of biosensor applications. The incorporation of bioactive materials, including DNA, aptamers and antibodies, into CNTs to produce composites of bioactive CNTs has attracted considerable attention. In addition, polymers are essential for the development of biosensors as they provide biocompatible conditions and are the ideal matrix for the immobilization of proteins. The numerous applications of bioactive compounds combined with the excellent chemical and physical properties of CNTs have led to the development of bioactive CNT-polymer composites. This article provides a comprehensive overview of CNT-polymer composites and new approaches to encapsulate bioactive compounds and polymers in CNTs. Finally, biosensor applications of bioactive CNT-polymer for the detection of glucose, H2O2 and cholesterol were investigated. The surface of CNT-polymer facilitates the immobilization of bioactive molecules such as DNA, enzymes or antibodies, which in turn enables the construction of state-of-the-art, future-oriented biosensors.
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Técnicas Biosensibles , Nanotubos de Carbono , Polímeros , Nanotubos de Carbono/química , Polímeros/química , Peróxido de Hidrógeno/análisis , Peróxido de Hidrógeno/química , Glucosa/análisis , Colesterol/análisis , Colesterol/química , HumanosRESUMEN
Saint Martin Island (SMI), the only coral island in Bangladesh, is located in the Bay of Bengal and has been identified as a marine protected area (MPA). Littering cigarette butts (CBs) waste in an ecologically sensitive environment can have numerous adverse effects. The purpose of this research is to investigate the abundance and density of CBs in SMI and to assess the pollution status using the Cigarette Butt Pollution Index (CBPI). This study is conducted based on the visual survey method in the three types of land use zones of SMI. During the peak season, the investigation was carried out from 9 a.m. to 5 p.m. in December 2023. A total of 4481 CBs item were counted, and the density ranged from 0.37 to 1.76 m-2 with an average value of 0.99 m-2 across 12 sampling campaigns. The highest density was observed at service zones, and the fishing zones had the lowest density. The calculated CBPI values revealed that 75 % of the sampling stations were in the "severe pollution" while 25 % were classified as "high pollution" status, underscoring the prevalence of hazardous CBs across most areas of SMI. To tackle these issues requires regulatory measures, public awareness initiatives, and community involvement. Effective waste management and eco-friendly product promotion can help reduce CBs pollution risks in marine protected islands.
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Conservación de los Recursos Naturales , Monitoreo del Ambiente , Islas , Bangladesh , Productos de TabacoRESUMEN
Saltwater intrusion in the coastal areas of Bangladesh is a prevalent phenomenon. However, it is not conducive to activities such as irrigation, navigation, fish spawning and shelter, and industrial usage. The present study analyzed 45 water samples collected from 15 locations in coastal areas during three seasons: monsoon, pre-monsoon, and post-monsoon. The aim was to comprehend the seasonal variation in physicochemical parameters, including water temperature, pH, electrical conductivity (EC), salinity, total dissolved solids (TDS), hardness, and concentrations of Na+, K+, Mg2+, Ca2+, Fe2+, HCO3-, PO43-, SO42-, and Cl-. Additionally, parameters essential for agriculture, such as soluble sodium percentage (SSP), sodium absorption ratio (SAR), magnesium absorption ratio (MAR), residual sodium carbonate (RSC), Kelly's ratio (KR), and permeability index (PI), were examined. Their respective values were found to be 63%, 16.83 mg/L, 34.92 mg/L, 145.44 mg/L, 1.28 mg/L, and 89.29%. The integrated water quality index was determined using entropy theory and principal component analysis (PCA). The resulting entropy water quality index (EWQI) and SAR of 49.56% and 63%, respectively, indicated that the samples are suitable for drinking but unsuitable for irrigation. These findings can assist policymakers in implementing the Bangladesh Deltaplan-2100, focusing on sustainable land management, fish cultivation, agricultural production, environmental preservation, water resource management, and environmental protection in the deltaic areas of Bangladesh. This research contributes to a deeper understanding of seasonal variations in the hydrochemistry and water quality of coastal rivers, aiding in the comprehension of salinity intrusion origins, mechanisms, and causes.
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Agua Potable , Agua Subterránea , Contaminantes Químicos del Agua , Calidad del Agua , Monitoreo del Ambiente/métodos , Ríos , Bangladesh , Sodio/análisis , Contaminantes Químicos del Agua/análisis , Agua Subterránea/análisis , Agua Potable/análisis , IndiaRESUMEN
The rapid developments in the field of zeolitic imidazolate frameworks (ZIFs) in recent years have created unparalleled opportunities for the development of unique bioactive ZIFs for a range of biosensor applications. Integrating bioactive molecules such as DNA, aptamers, and antibodies into ZIFs to create bioactive ZIF composites has attracted great interest. Bioactive ZIF composites have been developed that combine the multiple functions of bioactive molecules with the superior chemical and physical properties of ZIFs. This review thoroughly summarizes the ZIFs as well as the novel strategies for incorporating bioactive molecules into ZIFs. They are used in many different applications, especially in biosensors. Finally, biosensor applications of bioactive ZIFs were investigated in optical (fluorescence and colorimetric) and electrochemical (amperometric, conductometric, and impedance) fields. The surface of ZIFs makes it easier to immobilize bioactive molecules like DNA, enzymes, or antibodies, which in turn enables the construction of cutting-edge, futuristic biosensors.
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Técnicas Biosensibles , Imidazoles , Zeolitas , Zeolitas/química , Técnicas Biosensibles/métodos , Imidazoles/química , Estructuras Metalorgánicas/química , Humanos , Técnicas ElectroquímicasRESUMEN
The advancement of a sustainable and scalable catalyst for hydrogen production is crucial for the future of the hydrogen economy. Electrochemical water splitting stands out as a promising pathway for sustainable hydrogen production. However, the development of Pt-free electrocatalysts that match the energy efficiency of Pt while remaining economical poses a significant challenge. This review addresses this challenge by highlighting latest breakthroughs in Pt-free catalysts for the hydrogen evolution reaction (HER). Specifically, we delve into the catalytic performance of various transition metal phosphides, metal carbides, metal sulphides, and metal nitrides toward HER. Our discussion emphasizes strategies for enhancing catalytic performance and explores the relationship between structural composition and the performance of different electrocatalysts. Through this comprehensive review, we aim to provide insights into the ongoing efforts to overcome barriers to scalable hydrogen production and pave the way for a sustainable hydrogen economy.
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Electrochemical sensors have been the subject of much research and development as of late, with several publications detailing new designs boasting enhanced performance metrics. That is, without a doubt, because such sensors stand out from other analytical tools thanks to their excellent analytical characteristics, low cost, and ease of use. Their progress has shown a trend toward seeking out novel useful nano structure materials. A variety of nanostructure metal oxides have been utilized in the creation of potentiometric sensors, which are the subject of this article. For screen-printed pH sensors, metal oxides have been utilized as sensing layers due to their mixed ion-electron conductivity and as paste-ion-selective electrode components and in solid-contact electrodes. Further significant uses include solid-contact layers. All the metal oxide uses mentioned are within the purview of this article. Nanoscale metal oxides have several potential uses in the potentiometry method, and this paper summarizes such uses, including hybrid materials and single-component layers. Potentiometric sensors with outstanding analytical properties can be manufactured entirely from metal oxides. These novel sensors outperform the more traditional, conventional electrodes in terms of useful characteristics. In this review, we looked at the potentiometric analytical properties of different building solutions with various nanoscale metal oxides.
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Early detection and effective cancer treatment are critical to improving metastatic cancer cell diagnosis and management today. In particular, accurate qualitative diagnosis of metastatic cancer cell represents an important step in the diagnosis of cancer. Today, biosensors have been widely developed due to the daily need to measure different chemical and biological species. Biosensors are utilized to quantify chemical and biological phenomena by generating signals that are directly proportional to the quantity of the analyte present in the reaction. Biosensors are widely used in disease control, drug delivery, infection detection, detection of pathogenic microorganisms, and markers that indicate a specific disease in the body. These devices have been especially popular in the field of metastatic cancer cell diagnosis and treatment due to their portability, high sensitivity, high specificity, ease of use and short response time. This article examines biosensors for metastatic cancer cells. It also studies metastatic cancer cells and the mechanism of metastasis. Finally, the function of biosensors and biomarkers in metastatic cancer cells is investigated.
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Técnicas Biosensibles , Metástasis de la Neoplasia , Neoplasias , Humanos , Biomarcadores de Tumor/análisis , Biomarcadores de Tumor/metabolismo , Técnicas Biosensibles/métodos , Neoplasias/diagnóstico , Neoplasias/patologíaRESUMEN
The development of green hydrogen generation technologies is increasingly crucial to meeting the growing energy demand for sustainable and environmentally acceptable resources. Many obstacles in the advancement of electrodes prevented water electrolysis, long thought to be an eco-friendly method of producing hydrogen gas with no carbon emissions, from coming to fruition. Because of their great electrical conductivity, maximum supporting capacity, ease of modification in valence states, durability in hard environments, and high redox characteristics, transition metal oxides (TMOs) have recently captured a lot of interest as potential cathodes and anodes. Electrochemical water splitting is the subject of this investigation, namely the role of transition metal oxides as both active and supportive sites. It has suggested various approaches for the logical development of electrode materials based on TMOs. These include adjusting the electronic state, altering the surface structure to control its resistance to air and water, improving the flow of energy and matter, and ensuring the stability of the electrocatalyst in challenging conditions. In this comprehensive review, it has been covered the latest findings in electrocatalysis of the Oxygen Evolution Reaction (OER) and Hydrogen Evaluation Reaction (HER), as well as some of the specific difficulties, opportunities, and current research prospects in this field.
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Nanotechnology has emerged as a pivotal tool in biomedical research, particularly in developing advanced sensing platforms for disease diagnosis and therapeutic monitoring. Since gold nanoparticles are biocompatible and have special optical characteristics, they are excellent choices for surface-enhanced Raman scattering (SERS) sensing devices. Integrating fluorescence characteristics further enhances their utility in real-time imaging and tracking within biological systems. The synergistic combination of SERS and fluorescence enables sensitive and selective detection of biomolecules at trace levels, providing a versatile platform for early cancer diagnosis and drug monitoring. In cancer detection, AuNPs facilitate the specific targeting of cancer biomarkers, allowing for early-stage diagnosis and personalized treatment strategies. The enhanced sensitivity of SERS, coupled with the tunable fluorescence properties of AuNPs, offers a powerful tool for the identification of cancer cells and their microenvironment. This dual-mode detection not only improves diagnostic accuracy but also enables the monitoring of treatment response and disease progression. In drug detection, integrating AuNPs with SERS provides a robust platform for identifying and quantifying pharmaceutical compounds. The unique spectral fingerprints obtained through SERS enable the discrimination of drug molecules even in complex biological matrices. Furthermore, the fluorescence property of AuNPs makes it easier to track medication distribution in real-time, maximizing therapeutic effectiveness and reducing adverse effects. Furthermore, the review explores the role of gold fluorescence nanoparticles in photodynamic therapy (PDT). By using the complementary effects of targeted drug release and light-induced cytotoxicity, SERS-guided drug delivery and photodynamic therapy (PDT) can increase the effectiveness of treatment against cancer cells. In conclusion, the utilization of gold fluorescence nanoparticles in conjunction with SERS holds tremendous potential for revolutionizing cancer detection, drug analysis, and photodynamic therapy. The dual-mode capabilities of these nanomaterials provide a multifaceted approach to address the challenges in early diagnosis, treatment monitoring, and personalized medicine, thereby advancing the landscape of biomedical applications.
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In this study, poly(luminol-co-1,8-diaminonaphthalene) (PLim-DAN) was synthesized and subsequently modified with MWCNTs and CeO2 NPs. The synthesized nanocomposites were analyzed using IR, SEM, TEM, and XRD. Furthermore, a comprehensive set of thermal behavior measurements were taken using TGA/DTG analysis. Next, the electroactivity of the developed nanocomposites was tested as an electrochemical sensor to measure the concentration of Cr3+ ions in phosphate buffers. The GCE adapted with the PLim-DAN/CeO2/CNTs-10% nanocomposite (NC) exhibited the highest current response among the other compositions and copolymers. The fabricated nanocomposite sensor showed high sensitivity, with a value of 19.78 µA µM-1 cm-2, and a low detection limit of 4.80 ± 0.24 pM. The analytical performance was evaluated by plotting a current calibration curve versus the concentration of Cr3+ ions. It was found to be linear (R2 = 0.9908) over the range of 0.1 nM to 0.1 mM, identified as the linear dynamic range (LDR). This electrochemical sensor demonstrated that it could be a useful tool for environmental monitoring by accurately detecting and measuring carcinogenic Cr3+ ions in real-world samples.