[Pathogenetic basis of modern approaches to the therapy of sleep disorders in the clinic of depression]. / Patogeneticheskie osnovy sovremennykh podkhodov v terapii narushenii sna v klinike depressii.

Epidemiological studies indicate that about 35% of the world's population periodically suffer from insomnia. Many authors in their studies note sleep disturbances in the clinic of both somatic and mental disorders, often considering sleep disturbances as one of the predictors of these diseases. In psychiatric practice, sleep disorders are most often described in the clinic of depression, which is determined by the general pathophysiological mechanisms of their development due to disruption of the activity of the main neurotransmitter systems of the brain. The results of clinical studies show that the drug of choice in the treatment of sleep disorders in the depression clinic is the antidepressant Mirtazapine, which has a unique profile of pharmacological activity. According to international recommendations, Mirtazapine is a first-line drug in the treatment of anxiety and depressive disorders with sleep disorders and sexual dysfunction caused by taking other antidepressants.

[Enzymes protecting the erythrocyte membrane during the combined exposure to an antioxidant complex and acute irradiation]. / Fermenty zashchity membran éritrotsitov pri sochetannom vvedenii antioksidantnogo kompleksa i ostrom obluchenii.

The data are presented concerning the effect of ionizing radiation on the hemolytic process and the influence of an antioxidant vitamin complex on the pentosephosphate metabolism and glutathione reductase activity after gamma-irradiation. The antioxidant vitamin complex has been shown to produce a favourable effect on the erythrocyte membrane stability in correcting the radiation-induced changes.

[Effect of metabolites on the activity of enzymes protecting the stability of the erythrocyte membrane in experimental decompression sickness]. / Vliianie metabolitov na aktivnost' fermentov, obespechivaiushchikh stabil'nost' membran éritrotsitov pri dekompressionnoi bolezni v éksperimente.

Metabolites have been studied for their effect (sodium succinate, thiamine, riboflavin) on the pentosophosphate pathways and glutathione reductase. The possible mechanisms of its influence on the membrane stability of erythrocytes in decompression disease are discussed.