[DIAGNOSTIC EFFICIENCY OF THE USE OF A MAGNIFYING CHROMOENDOSCOPY WHEN EXAMINING THE ORAL CAVITY IN PATIENTS WITH A GASTROENTEROLOGICAL PROFILE WITH EXTRAESOPHAGEAL MANIFESTATIONS OF REFLUX DISEASE].

The article is devoted to the study of the diagnostic effectiveness of using magnifying chromoendoscopy when examining the oral cavity in patients with a gastroenterological profile with extra-esophageal manifestations of reflux disease. Pathologies of the oral cavity are often one of the additional symptoms, according to the Montreal Consensus and classification of gastroesophageal reflux disease (GERD). Barrett's esophagus is a serious complication of GERD, in which a cylindrical epithelium with intestinal metaplasia is found in the epithelial lining of the mucous membrane of the esophagus, which is a marker of this disease often in combination with dysplasia instead of squamous stratified non-keratinized epithelium. The relevance is due to the fact that this disease is considered as a precancerous condition and is associated with an increased risk of developing adenocarcinoma of the lower third of the esophagus. In this regard, timely diagnosis of Barrett's esophagus and monitoring of these patients will improve the prognosis of the disease and reduce the frequency of deaths.

[Biochemical markers of oxidative stress in different forms and phases of multiple sclerosis].

OBJECTIVE: To verify a role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and to develop oxidative stress prognostic criteria of disease course and treatment recommendations. MATERIAL AND METHODS: We examined 220 patients with different clinical forms and phases of MS. The lipid and protein free-radical oxidation markers were measured using the following parameters: ketodienes, diene conjugates, malondialdehyde, and Schiff bases. The functioning of the endogenous antioxidant defense system was assessed using y the activity of vitamin E, general and non-protein SH-groups, which represented the nonenzymatic segment of the antioxidant defense system. The enzymatic segment markers were superoxide dismutase, glutathione peroxidase, and glutathione reductase. RESULTS AND CONCLUSION: The findings revealed significant differences in the oxidative stress intensity indices in patients with different clinical forms and phases of MS, which made it possible to predict disease progression and prescribe the complex antioxidant treatment in the evidence-based practice.