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Bioorg Med Chem
; 14(19): 6492-501, 2006 Oct 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16860559
RESUMEN
A series of combretastatin A-4 analogs derived from the ATP competitive, VEGF receptor tyrosine kinase inhibitor, SU5416 were synthesized. The cytotoxic effects of the analogs were evaluated against PC-3 and MDA-MB-231 cancer cell lines, as well as their abilities to inhibit tubulin polymerization. Results are compared to those of compound 1, our lead compound previously reported.