BRACETS: Bimodal repository of auscultation coupled with electrical impedance thoracic signals.

BACKGROUND AND OBJECTIVE: Respiratory diseases are among the most significant causes of morbidity and mortality worldwide, causing substantial strain on society and health systems. Over the last few decades, there has been increasing interest in the automatic analysis of respiratory sounds and electrical impedance tomography (EIT). Nevertheless, no publicly available databases with both respiratory sound and EIT data are available. METHODS: In this work, we have assembled the first open-access bimodal database focusing on the differential diagnosis of respiratory diseases (BRACETS: Bimodal Repository of Auscultation Coupled with Electrical Impedance Thoracic Signals). It includes simultaneous recordings of single and multi-channel respiratory sounds and EIT. Furthermore, we have proposed several machine learning-based baseline systems for automatically classifying respiratory diseases in six distinct evaluation tasks using respiratory sound and EIT (A1, A2, A3, B1, B2, B3). These tasks included classifying respiratory diseases at sample and subject levels. The performance of the classification models was evaluated using a 5-fold cross-validation scheme (with subject isolation between folds). RESULTS: The resulting database consists of 1097 respiratory sounds and 795 EIT recordings acquired from 78 adult subjects in two countries (Portugal and Greece). In the task of automatically classifying respiratory diseases, the baseline classification models have achieved the following average balanced accuracy: Task A1 - 77.9±13.1%; Task A2 - 51.6±9.7%; Task A3 - 38.6±13.1%; Task B1 - 90.0±22.4%; Task B2 - 61.4±11.8%; Task B3 - 50.8±10.6%. CONCLUSION: The creation of this database and its public release will aid the research community in developing automated methodologies to assess and monitor respiratory function, and it might serve as a benchmark in the field of digital medicine for managing respiratory diseases. Moreover, it could pave the way for creating multi-modal robust approaches for that same purpose.

Automatic wheeze segmentation using harmonic-percussive source separation and empirical mode decomposition.

Wheezes are adventitious respiratory sounds commonly present in patients with respiratory conditions. The presence of wheezes and their time location are relevant for clinical reasons, such as understanding the degree of bronchial obstruction. Conventional auscultation is usually employed to analyze wheezes, but remote monitoring has become a pressing need during recent years. Automatic respiratory sound analysis is required to reliably perform remote auscultation. In this work we propose a method for wheeze segmentation. Our method starts by decomposing a given audio excerpt into intrinsic mode frequencies using empirical mode decomposition. Then, we apply harmonic-percussive source separation to the resulting audio tracks and get harmonic-enhanced spectrograms, which are processed to obtain harmonic masks. Subsequently, a series of empirically derived rules are applied to find wheeze candidates. Finally, the candidates stemming from the different audio tracks are merged and median filtered. In the evaluation stage, we compare our method to three baselines on the ICBHI 2017 Respiratory Sound Database, a challenging dataset containing various noise sources and background sounds. Using the full dataset, our method outperforms the baselines, achieving an F1 of 41.9%. Our method's performance is also better than the baselines across several stratified results focusing on five variables: recording equipment, age, sex, body-mass index, and diagnosis. We conclude that, contrary to what has been reported in the literature, wheeze segmentation has not been solved for real life scenario applications. Adaptation of existing systems to demographic characteristics might be a promising step in the direction of algorithm personalization, which would make automatic wheeze segmentation methods clinically viable.

Classification of Electrical Impedance Tomography Data Using Machine Learning.

Patients suffering from pulmonary diseases typically exhibit pathological lung ventilation in terms of homogeneity. Electrical Impedance Tomography (EIT) is a non- invasive imaging method that allows to analyze and quantify the distribution of ventilation in the lungs. In this article, we present a new approach to promote the use of EIT data and the implementation of new clinical applications for differential diagnosis, with the development of several machine learning models to discriminate between EIT data from healthy and nonhealthy subjects. EIT data from 16 subjects were acquired: 5 healthy and 11 non-healthy subjects (with multiple pulmonary conditions). Preliminary results have shown accuracy percentages of 66% in challenging evaluation scenarios. The results suggest that the pairing of EIT feature engineering methods with machine learning methods could be further explored and applied in the diagnostic and monitoring of patients suffering from lung diseases. Also, we introduce the use of a new feature in the context of EIT data analysis (Impedance Curve Correlation).

Detection of squawks in respiratory sounds of mechanically ventilated COVID-19 patients.

Mechanically ventilated patients typically exhibit abnormal respiratory sounds. Squawks are short inspiratory adventitious sounds that may occur in patients with pneumonia, such as COVID-19 patients. In this work we devised a method for squawk detection in mechanically ventilated patients by developing algorithms for respiratory cycle estimation, squawk candidate identification, feature extraction, and clustering. The best classifier reached an F1 of 0.48 at the sound file level and an F1 of 0.66 at the recording session level. These preliminary results are promising, as they were obtained in noisy environments. This method will give health professionals a new feature to assess the potential deterioration of critically ill patients.

Automatic Classification of Adventitious Respiratory Sounds: A (Un)Solved Problem?

(1) Background: Patients with respiratory conditions typically exhibit adventitious respiratory sounds (ARS), such as wheezes and crackles. ARS events have variable duration. In this work we studied the influence of event duration on automatic ARS classification, namely, how the creation of the Other class (negative class) affected the classifiers' performance. (2) Methods: We conducted a set of experiments where we varied the durations of the other events on three tasks: crackle vs. wheeze vs. other (3 Class); crackle vs. other (2 Class Crackles); and wheeze vs. other (2 Class Wheezes). Four classifiers (linear discriminant analysis, support vector machines, boosted trees, and convolutional neural networks) were evaluated on those tasks using an open access respiratory sound database. (3) Results: While on the 3 Class task with fixed durations, the best classifier achieved an accuracy of 96.9%, the same classifier reached an accuracy of 81.8% on the more realistic 3 Class task with variable durations. (4) Conclusion: These results demonstrate the importance of experimental design on the assessment of the performance of automatic ARS classification algorithms. Furthermore, they also indicate, unlike what is stated in the literature, that the automatic classification of ARS is not a solved problem, as the algorithms' performance decreases substantially under complex evaluation scenarios.