RESUMEN
Calcium pantothenate (CAS no. 137-08-6) is the calcium salt of pantothenic acid (vitamin B5). It is used in cosmetics due to its anti-static and hair conditioning properties. A 53-year-old female nurse's aide presented with intermittent facial eruptions (Figure S1). Patch tests were positive to calcium pantothenate, an ingredient of two of her products (a cleansing milk and a facial tonic). To our knowledge, no previous cases of sensitization from calcium pantothenate have been reported except for one case of systemic dermatitis from a nutritional supplement in a dexpanthenol-sensitized patient.
Asunto(s)
Cosméticos/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Dermatosis Facial/inducido químicamente , Ácido Pantoténico/efectos adversos , Complejo Vitamínico B/efectos adversos , Diagnóstico Tardío , Dermatitis Alérgica por Contacto/diagnóstico , Dermatosis Facial/diagnóstico , Femenino , Humanos , Persona de Mediana Edad , Pruebas del ParcheAsunto(s)
Abdomen Agudo/etiología , Adenocarcinoma del Pulmón/secundario , Neoplasias del Yeyuno/secundario , Neoplasias Pulmonares/patología , Enfermedades Raras/complicaciones , Adenocarcinoma del Pulmón/diagnóstico por imagen , Neoplasias Encefálicas/secundario , Resultado Fatal , Femenino , Humanos , Neoplasias del Yeyuno/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Tomografía Computarizada por Rayos XRESUMEN
BACKGROUND: Liver metastases emerge during the course of colorectal cancer (CRC) in 25-50% of patients. A small proportion of patients present intrabiliary growth. The absence of large series means that little is known about intrabiliary metastasis (IBM), its radiological diagnosis, the most suitable surgical techniques, and its prognostic implications. METHODS: A systematic search without limits was performed. The studies selected included patients with a diagnosis of CRC and associated IBM, either synchronous or metachronous. RESULTS: Of 40 studies selected, 30 were case reports and 10 case series. The median time between diagnosis and IBM was 46.7 months (range 0-180). Most CRC metastases are CK7-/CK20+. Surgical treatment performed ranged from endoscopic resection to major hepatic resections combined with pancreatectomies. It seems that patients with IBM have a better survival than patients without this metastasis. CONCLUSION: In a patient with a history of CRC presenting dilatation of the bile duct, IBM should be considered. More studies are needed to determine the most appropriate type of liver resection. It is also necessary to standardize the definition and terminology of this pathology, since the existing definitions may cause confusion and make it difficult to carry out case studies and case series.