1.
Chem Commun (Camb)
; 52(40): 6669-72, 2016 May 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27115235
RESUMEN
The first examples of selective ortho-directed C-H activation with unprotected 2-aryltetrazoles are described. A new base-assisted protocol for iridium(i) hydrogen isotope exchange catalysis allows access to ortho-deuterated and tritiated tetrazoles, including the tetrazole-containing pharmaceutical, Valsartan. Preliminary mechanistic studies are also presented.