The RAGE Axis: A Relevant Inflammatory Hub in Human Diseases.

In 1992, a transcendental report suggested that the receptor of advanced glycation end-products (RAGE) functions as a cell surface receptor for a wide and diverse group of compounds, commonly referred to as advanced glycation end-products (AGEs), resulting from the non-enzymatic glycation of lipids and proteins in response to hyperglycemia. The interaction of these compounds with RAGE represents an essential element in triggering the cellular response to proteins or lipids that become glycated. Although initially demonstrated for diabetes complications, a growing body of evidence clearly supports RAGE's role in human diseases. Moreover, the recognizing capacities of this receptor have been extended to a plethora of structurally diverse ligands. As a result, it has been acknowledged as a pattern recognition receptor (PRR) and functionally categorized as the RAGE axis. The ligation to RAGE leads the initiation of a complex signaling cascade and thus triggering crucial cellular events in the pathophysiology of many human diseases. In the present review, we intend to summarize basic features of the RAGE axis biology as well as its contribution to some relevant human diseases such as metabolic diseases, neurodegenerative, cardiovascular, autoimmune, and chronic airways diseases, and cancer as a result of exposure to AGEs, as well as many other ligands.

Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus.

Type 2 diabetes mellitus (T2DM) is recognized as a serious public health concern with a considerable impact on human life, long-term health expenditures, and substantial health losses. In this context, the use of dietary polyphenols to prevent and manage T2DM is widely documented. These dietary compounds exert their beneficial effects through several actions, including the protection of pancreatic islet ß-cell, the antioxidant capacities of these molecules, their effects on insulin secretion and actions, the regulation of intestinal microbiota, and their contribution to ameliorate diabetic complications, particularly those of vascular origin. In the present review, we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.

Gallbladder Cancer Risk and Indigenous South American Mapuche Ancestry: Instrumental Variable Analysis Using Ancestry-Informative Markers.

A strong association between the proportion of indigenous South American Mapuche ancestry and the risk of gallbladder cancer (GBC) has been reported in observational studies. Chileans show the highest incidence of GBC worldwide, and the Mapuche are the largest indigenous people in Chile. We set out to assess the confounding-free effect of the individual proportion of Mapuche ancestry on GBC risk and to investigate the mediating effects of gallstone disease and body mass index (BMI) on this association. Genetic markers of Mapuche ancestry were selected based on the informativeness for assignment measure, and then used as instrumental variables in two-sample Mendelian randomization analyses and complementary sensitivity analyses. Results suggested a putatively causal effect of Mapuche ancestry on GBC risk (inverse variance-weighted (IVW) risk increase of 0.8% per 1% increase in Mapuche ancestry proportion, 95% CI 0.4% to 1.2%, p = 6.7 × 10-5) and also on gallstone disease (3.6% IVW risk increase, 95% CI 3.1% to 4.0%), pointing to a mediating effect of gallstones on the association between Mapuche ancestry and GBC. In contrast, the proportion of Mapuche ancestry showed a negative effect on BMI (IVW estimate -0.006 kg/m2, 95% CI -0.009 to -0.003). The results presented here may have significant implications for GBC prevention and are important for future admixture mapping studies. Given that the association between the individual proportion of Mapuche ancestry and GBC risk previously noted in observational studies appears to be free of confounding, primary and secondary prevention strategies that consider genetic ancestry could be particularly efficient.

Exploring the Interplay between Polyphenols and Lysyl Oxidase Enzymes for Maintaining Extracellular Matrix Homeostasis.

Collagen, the most abundant structural protein found in mammals, plays a vital role as a constituent of the extracellular matrix (ECM) that surrounds cells. Collagen fibrils are strengthened through the formation of covalent cross-links, which involve complex enzymatic and non-enzymatic reactions. Lysyl oxidase (LOX) is responsible for catalyzing the oxidative deamination of lysine and hydroxylysine residues, resulting in the production of aldehydes, allysine, and hydroxyallysine. These intermediates undergo spontaneous condensation reactions, leading to the formation of immature cross-links, which are the initial step in the development of mature covalent cross-links. Additionally, non-enzymatic glycation contributes to the formation of abnormal cross-linking in collagen fibrils. During glycation, specific lysine and arginine residues in collagen are modified by reducing sugars, leading to the creation of Advanced Glycation End-products (AGEs). These AGEs have been associated with changes in the mechanical properties of collagen fibers. Interestingly, various studies have reported that plant polyphenols possess amine oxidase-like activity and can act as potent inhibitors of protein glycation. This review article focuses on compiling the literature describing polyphenols with amine oxidase-like activity and antiglycation properties. Specifically, we explore the molecular mechanisms by which specific flavonoids impact or protect the normal collagen cross-linking process. Furthermore, we discuss how these dual activities can be harnessed to generate properly cross-linked collagen molecules, thereby promoting the stabilization of highly organized collagen fibrils.

Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country.

Since 2006, Chile has been implementing a gallbladder cancer (GBC) prevention program based on prophylactic cholecystectomy for gallstone patients aged 35 to 49 years. The effectiveness of this prevention program has not yet been comprehensively evaluated. We conducted a retrospective study of 473 Chilean GBC patients and 2137 population-based controls to develop and internally validate three GBC risk prediction models. The Baseline Model accounted for gallstones while adjusting for sex and birth year. Enhanced Model I also included the non-genetic risk factors: body mass index, educational level, Mapuche surnames, number of children and family history of GBC. Enhanced Model II further included Mapuche ancestry and the genotype for rs17209837. Multiple Cox regression was applied to assess the predictive performance, quantified by the area under the precision-recall curve (AUC-PRC) and the number of cholecystectomies needed (NCN) to prevent one case of GBC at age 70 years. The AUC-PRC for the Baseline Model (0.44%, 95%CI 0.42-0.46) increased by 0.22 (95%CI 0.15-0.29) when non-genetic factors were included, and by 0.25 (95%CI 0.20-0.30) when incorporating non-genetic and genetic factors. The overall NCN for Chileans with gallstones (115, 95%CI 104-131) decreased to 92 (95%CI 60-128) for Chileans with a higher risk than the median according to Enhanced Model I, and to 80 (95%CI 59-110) according to Enhanced Model II. In conclusion, age, sex and gallstones are strong risk factors for GBC, but consideration of other non-genetic factors and individual genotype data improves risk prediction and may optimize allocation of financial resources and surgical capacity.

Contributions of the receptor for advanced glycation end products axis activation in gastric cancer.

Compelling shreds of evidence derived from both clinical and experimental research have demonstrated the crucial contribution of receptor for advanced glycation end products (RAGE) axis activation in the development of neoplasms, including gastric cancer (GC). This new actor in tumor biology plays an important role in the onset of a crucial and long-lasting inflammatory milieu, not only by supporting phenotypic changes favoring growth and dissemination of tumor cells, but also by functioning as a pattern-recognition receptor in the inflammatory response to Helicobacter pylori infection. In the present review, we aim to highlight how the overexpression and activation of the RAGE axis contributes to the proliferation and survival of GC cells as and their acquisition of more invasive phenotypes that promote dissemination and metastasis. Finally, the contribution of some single nucleotide polymorphisms in the RAGE gene as susceptibility or poor prognosis factors is also discussed.

Objective characterization of dental occlusal and fissure morphologies: Method development and exploratory analysis.

OBJECTIVE: To develop clinically applicable methods to characterize occlusal topography and assess possible associations between morphology and caries incidence and development. DESIGN: In this retrospective clinical study, we evaluated caries presence and severity pre- and post-orthodontic treatment for first molars of 147 patients (384 teeth). These teeth were previously scanned using a clinical intraoral scanner, and the obtained digital elevation models were used to 1) analyze the 3D occlusal surface parameters (n = 384) and 2) quantitatively characterize the mandibular molars' (n = 166) fissure patterns using three novel methods. Pearson correlation coefficients were calculated to evaluate the associations among the measurements, and presence/severity of caries pre- and post-treatment were assessed using generalized linear mixed-effects models. RESULTS: Robust quantitative fissure characterizations were developed, and reliable occlusal surface parameters were obtained. In the studied population, none of the parametric measurements (Slope: p = 0.62 for presence, p = 0.96 for severity; Relief Index (RFI): p = 0.36, p = 0.84; Orientation Patch Count rotated (OPCr): p = 0.48, p = 0.13; Dirichlet Normal Energy (DNE): p = 0.91, p = 0.15) or the fissure morphological measurements (Mesial Angle: p = 0.43; Distal Angle: p = 0.86; Average Angle: p = 0.52; Area Difference: p = 0.83; Percent Fissure: p = 0.68) were found to be significantly associated with caries status or severity. CONCLUSION: Despite the lack of correlation in the limited studied sample, the tools developed to characterize occlusal surface topography and fissure morphology have the potential to be used in more comprehensive clinical evaluations.

Association between diabetes and cancer. Current mechanistic insights into the association and future challenges.

Compelling pieces of epidemiological, clinical, and experimental research have demonstrated that Diabetes mellitus (DM) is a major risk factor associated with increased cancer incidence and mortality in many human neoplasms. In the pathophysiology context of DM, many of the main classical actors are relevant elements that can fuel the different steps of the carcinogenesis process. Hyperglycemia, hyperinsulinemia, metabolic inflammation, and dyslipidemia are among the classic contributors to this association. Furthermore, new emerging actors have received particular attention in the last few years, and compelling data support that the microbiome, the epigenetic changes, the reticulum endoplasmic stress, and the increased glycolytic influx also play important roles in promoting the development of many cancer types. The arsenal of glucose-lowering therapeutic agents used for treating diabetes is wide and diverse, and a growing body of data raised during the last two decades has tried to clarify the contribution of therapeutic agents to this association. However, this research area remains controversial, because some anti-diabetic drugs are now considered as either promotors or protecting elements. In the present review, we intend to highlight the compelling epidemiological shreds of evidence that support this association, as well as the mechanistic contributions of many of these potential pathological mechanisms, some controversial points as well as future challenges.

Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider.

Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms, including gallbladder cancer. In this regard, data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products (RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu, thus supporting tumor growth and development. AGEs are formed in biological systems or foods, and food-derived AGEs, also known as dietary AGEs are known to contribute to the systemic pool of AGEs. Once they bind to RAGE, the activation of multiple and crucial signaling pathways are triggered, thus favoring the secretion of several proinflammatory cytokines also involved in the promotion of gallbladder cancer invasion and migration. In the present review, we aimed to highlight the relevance of the association between high dietary AGEs intakes and high risk for gallbladder cancer, and emerging data supporting that dietary intervention to reduce gallbladder cancer risk is a very attractive approach that deserves much more research efforts.

The RAGE/multiligand axis: a new actor in tumor biology.

The receptor for advanced glycation end-products (RAGE) is a multiligand binding and single-pass transmembrane protein which actively participates in several chronic inflammation-related diseases. RAGE, in addition to AGEs, has a wide repertoire of ligands, including several damage-associated molecular pattern molecules or alarmins such as HMGB1 and members of the S100 family proteins. Over the last years, a large and compelling body of evidence has revealed the active participation of the RAGE axis in tumor biology based on its active involvement in several crucial mechanisms involved in tumor growth, immune evasion, dissemination, as well as by sculpturing of the tumor microenvironment as a tumor-supportive niche. In the present review, we will detail the consequences of the RAGE axis activation to fuel essential mechanisms to guarantee tumor growth and spreading.

Corazón y desentrenamiento deportivo en atletas de polo acuático / Heart and Sports Detraining in Water Polo Athletes

RESUMEN El equilibrio del corazón en los deportistas favorece una estabilidad morfológica y funcional que propicie parámetros de función cardiovascular en rangos de normalidad, manifestado en adecuados valores de: tensión arterial sistólica y diastólica, frecuencia cardíaca, respiratoria y aptitud física para el entrenamiento y actividades diarias. Debido a los sacrificios biológicos que esto implica, los atletas retirados de polo acuático sufren de adaptaciones morfofuncionales cardiovasculares que deben ser atendidas cuando aceptan el retiro y pasan al desentrenamiento deportivo, que constituye una estrategia profiláctica y terapéutica para el cuidado de la salud de los atletas. Se proponen intervenciones tempranas, con programaciones de trabajo aerobio, para equilibrar las adaptaciones morfofuncionales cardiovasculares en atletas retirados del alto rendimiento.

ABSTRACT The balance of the heart in athletes favors morphological and functional stability that favors cardiovascular function parameters within normal ranges, manifested in adequate values of: systolic and diastolic blood pressure, heart rate, respiratory rate and physical fitness for training and daily activities. Due to the biological sacrifices that this implies, retired water polo athletes suffer from cardiovascular morphofunctional adaptations that must be addressed when they accept retirement and move on to sports detraining, which constitutes a prophylactic and therapeutic strategy for the health care of athletes. Early interventions are proposed, with aerobic work schedules, to balance cardiovascular morphofunctional adaptations in retired high-performance athletes.

La rentabilidad del viraje en nadadoras del estilo libre

La investigación se refiere a un estudio de la rentabilidad de la acción del viraje del estilo libre en nadadoras escolares. El objetivo para la investigación se centró en evaluar las características temporales durante la acción del viraje en nadadoras de la categoría 13 y 14 años de la provincia de Sancti Spíritus. Para la recogida de la información, se utilizaron los métodos del nivel empírico: la observación científica, así como la de medición. Se utilizaron dos cámaras de videos, ubicadas en serie, y una cámara subacuática marca Sony. Para el análisis temporal, se requirió del software Kinovea, ver 0.9.3. Se aplicó el test de 15 m. para comprobar la rentabilidad del viraje. Se pudo comprobar una pobre efectividad de este elemento técnico en el estilo libre en las nadadoras evaluadas, lo que mostró, de forma generalizada, deficiencias durante la fase de impulso y se comprobó la formación de ángulos muy abiertos de las piernas que favoreció un déficit en la utilización de la potencia de las piernas durante el empuje de la pared, aspecto este que ayudó a disminuir el deslizamiento y comenzar a realizar los movimientos de salida a la superficie de forma prematura, aumentó el tiempo de forma general en la ejecución del viraje, concluyendo que para las categorías escolares es oportuno obtener ángulos entre las articulaciones de tobillos, rodillas y cadera en el rango de los 90° y 110° al momento de iniciar el impulso de la pared.

A pesquisa diz respeito a um estudo sobre a rentabilidade da ação de viragem em estilo livre em nadadores escolares. O objectivo da investigação foi centrado na avaliação das características temporárias durante a ação de viragem em nadadores de 13 e 14 anos de idade na província de Sancti Spíritus. Para a recolha de informação, foram empregues métodos empíricos: observação científica e medição. Foram instaladas duas câmaras de vídeo, colocadas em série, e uma câmara subaquática Sony. Para a análise temporal, foi utilizado o software Kinovea, ver 0.9.3. O teste de 15 m foi executado para verificar a relação custo-benefício da curva. Foi possível constatar uma baixa eficácia deste elemento técnico no estilo livre dos nadadores avaliados, que mostraram, em geral, deficiências durante a fase de impulso e a formação de ângulos de pernas muito abertos que favoreceram um défice na utilização da força das pernas durante o impulso para a parede, Este aspecto permitiu reduzir o deslizamento e começar a realizar os movimentos de saída para a superfície antecipadamente, aumentou o tempo total na execução da curva, concluindo-se que para as categorias escolares é adequado obter ângulos entre o calcanhar, o joelho e as articulações da anca na gama de 90° e 110° no momento de iniciar o impulso da parede.

The research refers to a study of the profitability of the freestyle turning action in school swimmers. The objective of the research was focused on evaluating the temporal characteristics during the action of the turn in swimmers of the 13 and 14 years old category in the province of Sancti Spíritus. For the collection of information, the empirical level methods used were: scientific observation, as well as measurement. Two video cameras, placed in series, and a Sony underwater camera were used. For the temporal analysis, the Kinovea software, ver 0.9.3, was used. The 15 m test was applied to check the profitability of the turn. It was possible to verify a poor effectiveness of this technical element in the freestyle in the swimmers evaluated, which showed, in a generalized way, deficiencies during the impulse phase and the formation of very open angles of the legs that favored a deficit in the use of the power of the legs during the wall push, This aspect helped to decrease the sliding and to begin to perform the exit movements to the surface prematurely, increased the time in general in the execution of the turn, concluding that for the school categories it is appropriate to obtain angles between the ankle, knee and hip joints in the range of 90° and 110° at the moment of initiating the wall push.

La transferencia de los ejercicios de fuerza al medio acuático en la segunda etapa de formación básica en el polo acuático

En la formación deportiva, tener presente cómo desarrollar la fuerza en tierra y su transferencia al medio acuático es de vital importancia en la formación de los atletas que comienzan la práctica del polo acuático. La presente investigación tuvo como objetivo determinar cómo los ejercicios de transferencia de fuerza influyen en las acciones motrices del polo acuático, lo que ayudaría a una adecuada conducción del proceso de formación deportiva de las atletas investigadas. Para lograr las metas propuestas, los autores se apoyaron en métodos teóricos y empíricos, se utilizó la herramienta de la estadística descriptiva (cálculo porcentual) para procesar la información, tomando como muestra a atletas que se iniciaban en el polo acuático en el área deportiva masiva de Polo Acuático. Para ello, se realizó una encuesta a entrenadores y se analizaron sus opiniones y criterios durante la conducción de este proceso. El resultado final es que son insuficientes los conocimientos de cómo seleccionar los ejercicios para que se desarrolle una transferencia positiva al medio acuático de los ejercicios de fuerza en tierra. No dominan los métodos, procedimientos, contenidos y metodologías, a partir de las investigaciones realizadas sobre el principio y ejercicios de transferencia. Entre las conclusiones más relevantes de esta investigación, se encuentran los referentes teóricos sobre los ejercicios de transferencia de fuera en tierra al medio acuático, lo que aportará desde la teoría una argumentación sólida para su aplicación a la práctica.

No treino desportivo, é de importância primordial ter em conta como evoluir a força em terra e a sua transferência para o meio aquático ou entorno hídrico, no treino dos atletas iniciantes na prática de pólo aquático. O objectivo desta investigação era descobrir como os exercícios de transferência de força influenciam as ações motoras no pólo aquático, o que contribuiria para a correta condução do processo de treino desportivo dos atletas inquiridos. Para alcançar os objectivos propostos, os autores apoiaram-se em métodos teóricos e empíricos, recorrendo à ferramenta da estatística descritiva (cálculo de percentagens) para processar a informação, tomando como modelo os atletas que estavam a começar no pólo aquático no campo do pólo aquático de desportos coletivos. Para este efeito, foi realizado um inquérito com os treinadores e as suas opiniões e critérios foram analisados durante a realização deste processo. O resultado final é que não há conhecimentos suficientes sobre como escolher exercícios para desenvolver uma transferência positiva de força em terra, para o ambiente aquático. Não dominam os métodos, procedimentos, conteúdos e metodologias, com base na investigação efetuada sobre o princípio e exercícios de transferência. Entre as conclusões mais relevantes desta investigação figuram as referências teóricas sobre os exercícios de transferência da terra para o meio aquático, que fornecerão da teoria uma argumentação sólida para a sua aplicação à prática.

In sports training, having in mind how to develop strength on land and its transfer to the aquatic environment is of vital importance in the training of athletes who begin the practice of water polo. The present research had the objective of determining how the strength transfer exercises influence the motor actions of water polo, which would help in an adequate conduction of the sports training process of the female athletes studied. To achieve the proposed goals, the authors relied on theoretical and empirical methods, the descriptive statistics tool (percentage calculation) was used to process the information, taking as a sample athletes who were starting in water polo in the massive sports area of Water Polo. For this purpose, a survey was made to coaches and their opinions and criteria were analyzed during the conduction of this process. The final result is that there is insufficient knowledge of how to select exercises so that a positive transfer to the aquatic environment of strength exercises on land is developed. They do not master the methods, procedures, contents and methodologies, based on the research carried out on the principle and exercises of transfer. Among the most relevant conclusions of this research are the theoretical references on the transfer exercises from land to the aquatic environment, which will provide from the theory a solid argumentation for its application to practice.

Identification of Circulating lncRNAs Associated with Gallbladder Cancer Risk by Tissue-Based Preselection, Cis-eQTL Validation, and Analysis of Association with Genotype-Based Expression.

Long noncoding RNAs (lncRNAs) play key roles in cell processes and are good candidates for cancer risk prediction. Few studies have investigated the association between individual genotypes and lncRNA expression. Here we integrate three separate datasets with information on lncRNA expression only, both lncRNA expression and genotype, and genotype information only to identify circulating lncRNAs associated with the risk of gallbladder cancer (GBC) using robust linear and logistic regression techniques. In the first dataset, we preselect lncRNAs based on expression changes along the sequence "gallstones → dysplasia → GBC". In the second dataset, we validate associations between genetic variants and serum expression levels of the preselected lncRNAs (cis-lncRNA-eQTLs) and build lncRNA expression prediction models. In the third dataset, we predict serum lncRNA expression based on individual genotypes and assess the association between genotype-based expression and GBC risk. AC084082.3 and LINC00662 showed increasing expression levels (p-value = 0.009), while C22orf34 expression decreased in the sequence from gallstones to GBC (p-value = 0.04). We identified and validated two cis-LINC00662-eQTLs (r2 = 0.26) and three cis-C22orf34-eQTLs (r2 = 0.24). Only LINC00662 showed a genotyped-based serum expression associated with GBC risk (OR = 1.25 per log2 expression unit, 95% CI 1.04-1.52, p-value = 0.02). Our results suggest that preselection of lncRNAs based on tissue samples and exploitation of cis-lncRNA-eQTLs may facilitate the identification of circulating noncoding RNAs linked to cancer risk.

Impact of early childhood caries severity on oral health-related quality of life among preschool children in Mexico: A cross-sectional study.

BACKGROUND: Information is scarce on Early Childhood Caries (ECC) in Mexican preschool children and its impact on quality of life. AIM: To evaluate the ECC prevalence and its impact on OHRQoL in 3-5 years-old Mexican children according to disease severity. DESIGN: Caries was determined at two thresholds: (1) children with at least one caries lesion (ICDAS-1-6) and (2) children with at least one lesion in dentin (ICDAS-3-6). OHRQoL was assessed through the Mexican Early Childhood Oral Health Impact Scale (M-ECOHIS). Associations among caries severity, M-ECOHIS, and other variables were assessed by ordinal logistic regression. RESULTS: A total of 409 children participated (53.8% girls, 46.2% boys). Caries prevalence was 82.2% considering all lesions, and 45.0% for dentinal lesions. Significant linear trends (p < .05) among caries levels and categories of exposure were found for socioeconomic variables, dietary habits, and toothbrushing habits. Attending rural private schools (OR = 1.39, 95%CI = 1.11-1.72; p < .01), two main meals/day (OR = 2.75, 95%CI = 1.26-6.03; p = .01) and unsupervised toothbrushing (OR = 3.20, 95%CI = 1.96-5.24; p < .01) increased the risk to have high caries severity levels. M-ECOHIS scores were statistically significant associated with caries levels (χ2 (4)  = 175.85, p < .01; trend across groups z = 12.63 Prob > |z| < 0.01). CONCLUSIONS: M-ECOHIS was significantly associated with caries severity. Type of school, age groups, parents' educational level, family income, and living conditions were correlated with caries, showing how distinctive risk indicators were associated with different caries stages.

Demarcated Primary Second Molar Hypomineralization: Prevalence Data and Associated Sociodemographic Determinants from Indiana.

Purpose: Demarcated primary second molar hypomineralization (DMH-Es) is a common developmental defect of enamel, with prevalence estimates between five percent and 20 percent. From the Americas, studies exploring the problem of DMH-Es and explicitly using the European Academy of Pediatric Dentistry diagnostic criteria were limited to some South American countries, but no similar studies were available from any of the North American countries including the United States. The purpose of this study was to investigate the prevalence and sociodemographic determinants of DMH-Es among schoolchildren in Indiana, USA. Methods: Four hundred twenty-three schoolchildren (average age equals 7.6 [±2.2 standard deviation] years) were examined by a calibrated pediatric dentist. Sociodemographic data were collected from patients' questionnaires and electronic dental records. Results: DMH-Es had a prevalence estimate of six percent versus 40 percent overall of any enamel defect (AED) of the primary second molars (PSMs) and/or the permanent first molars (PFMs). Race/ethnicity was significantly associated with a higher overall prevalence of AED of PSMs but not with the prevalence estimate of DMH-Es. Older age group (10 years or older), living in central Indiana, and water fluoridation were significantly associated with a higher overall prevalence of AEDs (P<0.01) but not with the prevalence of DMH-Es. Caries experience was significantly higher in children with demarcated molar hypomineralization (DMH) of PFMs and/or PSMs than in the group without. Conclusions: DMH-Es prevalence estimate was similar to the global figures. Certain demographic characteristics were significantly associated with the overall prevalence of the enamel defects of the examined teeth.

Pattern recognition receptors and their roles in the host response to Helicobacter pylori infection.

Helicobacter pylori (H. pylori) infection is highly prevalent, affecting 4.4 billion people globally. This pathogen is a risk factor in the pathogenesis of more than 75% of worldwide cases of gastric cancer. Pattern recognition receptors are essential in the innate immune response to H. pylori infection. They recognize conserved pathogen structures and myriad alarmins released by host cells in response to microbial components, cytokines or cellular stress, thus triggering a robust proinflammatory response, which is crucial in H. pylori-induced gastric carcinogenesis. In this review, we intend to highlight the main pattern recognition receptors involved in the recognition and host response to H. pylori, as well as the main structures recognized and the subsequent inflammatory response.

Dietary AGEs as Exogenous Boosters of Inflammation.

Most chronic modern non-transmissible diseases seem to begin as the result of low-grade inflammation extending over prolonged periods of time. The importance of diet as a source of many pro-inflammatory compounds that could create and sustain such a low-grade inflammatory state cannot be ignored, particularly since we are constantly exposed to them during the day. The focus of this review is on specific components of the diet associated with inflammation, specifically advanced glycation end products (AGEs) that form during thermal processing of food. AGEs are also generated in the body in normal physiology and are widely recognized as increased in diabetes, but many people are unaware of the potential importance of exogenous AGEs ingested in food. We review experimental models, epidemiologic data, and small clinical trials that suggest an important association between dietary intake of these compounds and development of an inflammatory and pro-oxidative state that is conducive to chronic diseases. We compare dietary intake of AGEs with other widely known dietary patterns, such as the Mediterranean and the Dietary Approaches to Stop Hypertension (DASH) diets, as well as the Dietary Inflammation Index (DII). Finally, we delineate in detail the pathophysiological mechanisms induced by dietary AGEs, both direct (i.e., non-receptor-mediated) and indirect (receptor-mediated).

El desentrenamiento deportivo, una alternativa vital en atletas juveniles de polo acuático de alto rendimiento / Destreinamento esportivo, uma alternativa vital para os jovens atletas de Pólo Aquático de alto rendimento / Sports detraining, a vital alternative for high-performance youth water polo athletes

RESUMEN En la actualidad, en Cuba, muchos atletas que llegan a su edad de retiro no realizan procesos de desentrenamiento deportivo, lo que repercute en su estado de salud a mediano plazo; estos comienzan a sufrir de enfermedades crónicas no transmisibles, además de depresión y estados psicológicos no adecuados. La presente investigación tuvo como objetivo determinar las insuficiencias que se derivan en la conducción del proceso de desentrenamiento deportivo en atletas retirados. Para lograr las metas propuestas, los autores se apoyaron en métodos teóricos y empíricos; se utiliza la herramienta de la estadística descriptiva (cálculo porcentual) para procesar la información, tomando como muestra a atletas juveniles retirados de polo acuático, médicos deportivos, psicólogos y fisioterapeutas de medicina deportiva, a los que se les aplicaron entrevistas y analizaron sus opiniones durante la conducción de este proceso. El resultado final fue que es insuficiente el conocimiento de cómo realizar este proceso de desentrenamiento deportivo en la muestra estudiada, no dominan cabalmente los métodos, procedimientos, contenidos y metodologías, a partir de las investigaciones y preparaciones metodológicas sobre el tema que es vital en el deporte de alto rendimiento. Entre las conclusiones más relevantes de este trabajo, se encuentra que los referentes teóricos del desentrenamiento deportivo en la actualidad no cumplen las expectativas de los atletas que se retiran en las diversas agrupaciones deportivas y los atletas cuando se retiran no poseen información de cómo realizar este proceso.

RESUMO Atualmente, em Cuba, muitos atletas que atingem sua idade de aposentadoria não realizam processos de destreinamento esportivo, o que afeta sua saúde a médio prazo; eles começam a sofrer de doenças crônicas não transmissíveis, assim como depressão e estados psicológicos não adequados. A presente investigação tinha como objetivo determinar as insuficiências que derivam na condução do processo de destreinamento esportivo em atletas aposentados. Para atingir os objetivos propostos, os autores se basearam em métodos teóricos e empíricos; a ferramenta estatística descritiva (cálculo percentual) foi utilizada para processar as informações, tomando como amostra atletas juvenis de pólo aquático, aposentados; médicos esportivos, psicólogos e fisioterapeutas de medicina esportiva, aos quais foram aplicadas entrevistas e analisadas suas opiniões durante a condução deste processo. O resultado final foi que não há conhecimento suficiente de como realizar este processo de destreinamento do esporte na amostra estudada, eles não dominam totalmente os métodos, procedimentos, conteúdos e metodologias, baseados em pesquisas e preparativos metodológicos sobre o tema que é vital no esporte de alto rendimento. Dentre as conclusões mais relevantes deste trabalho, constata-se que as referências teóricas de desvalorização do esporte atualmente não atendem às expectativas dos atletas que se aposentam em vários grupos esportivos e os atletas quando se aposentam não têm informações sobre como realizar este processo.

ABSTRACT At present, in Cuba, many athletes who reach their retirement age do not carry out sports detraining processes, which affects their health in the medium term; they begin to suffer from chronic non-communicable diseases, as well as depression and inadequate psychological states. The objective of this research was to determine the inadequacies derived from the conduction of the sports detraining process in retired athletes. To achieve the proposed goals, the authors relied on theoretical and empirical methods; the descriptive statistics tool (percentage calculation) was used to process the information, taking as a sample retired youth water polo athletes, sports doctors, psychologists and sports medicine physiotherapists, to whom interviews were applied and their opinions during the conduction of this process were analyzed. The final result was that there is insufficient knowledge of how to carry out this sports detraining process in the sample studied, they do not fully master the methods, procedures, contents and methodologies, based on the research and methodological preparations on the subject that is vital in high performance sports. Among the most relevant conclusions of this work, it is found that the theoretical references of sports detraining currently do not meet the expectations of the athletes who retire in the various sports groups and the athletes when they retire do not have information on how to carry out this process.