RESUMEN
The study aimed to assess the chemical composition of Miconia ibaguensis leaves extracts and fractions obtained from the ethanolic extract (EE), along with evaluating their antifungal, antibacterial, antidiabetic, and antioxidant activities. The ethyl acetate fraction (EAF) exhibited potent antifungal activity against Candida spp (1.95-3.90â µg mL-1) and potent antioxidant activity in the DPPH (1.74±0.07â µg mL-1), FRAP (654.01±42.09â µmol ETrolox/gsample), and ORAC (3698.88±37.28â µmol ETrolox/gsample) methods. The EE displayed inhibition against the α-amylase enzyme (8.42±0.05â µg mL-1). Flavonoids, hydrolysable tannins, triterpenoids, and phenolic acids, identified in the EE and fractions via (-)-HPLC-ESI-MS/MS analysis, were found to contribute to the species' biological activity potentially. These findings suggest promising avenues for further research and potential applications in pharmacology and natural products, offering new possibilities in the fight against global health issues.
Asunto(s)
Antibacterianos , Antifúngicos , Antioxidantes , Hipoglucemiantes , Melastomataceae , Pruebas de Sensibilidad Microbiana , Extractos Vegetales , Hojas de la Planta , Hojas de la Planta/química , Extractos Vegetales/química , Extractos Vegetales/farmacología , Extractos Vegetales/aislamiento & purificación , Melastomataceae/química , Antioxidantes/farmacología , Antioxidantes/química , Antioxidantes/aislamiento & purificación , Antifúngicos/farmacología , Antifúngicos/química , Antifúngicos/aislamiento & purificación , Antibacterianos/farmacología , Antibacterianos/química , Antibacterianos/aislamiento & purificación , Hipoglucemiantes/farmacología , Hipoglucemiantes/química , Hipoglucemiantes/aislamiento & purificación , Candida/efectos de los fármacos , alfa-Amilasas/antagonistas & inhibidores , alfa-Amilasas/metabolismo , Flavonoides/química , Flavonoides/farmacología , Flavonoides/aislamiento & purificación , Cromatografía Líquida de Alta PresiónRESUMEN
Miconia, maior gênero de Melastomataceae, com cerca de 1050 espécies distribuídas na região neotropical, caracteriza-se pelas inflorescências terminais, pétalas de ápice arredondado ou emarginado e frutos carnosos. O gênero encontra-se subdividido em 12 seções, e as espécies da seção Miconia podem ser reconhecidas pelas anteras curtas e lineares, com ápice levemente atenuado e conectivo com apêndices ventrais. Este estudo foi baseado no exame morfológico de ca. 2300 exsicatas, depositadas em 15 herbários brasileiros, e revelou a ocorrência de 26 espécies da seção Miconia em Minas Gerais. São apresentadas ilustrações, chave de identificação, dados de floração e frutificação, comentários e Estado de conservação para todas as espécies de Miconia seção Miconia no Estado de Minas Gerais.
Miconia is the largest genus in Melastomataceae, with about 1050 species distributed through the neotropics, and can be recognized by the terminal inflorescences, rounded or emarginated petals and fleshy fruits. The genus is divided in 12 sections, and the species from section Miconia can be recognized by the short and linear anthers, with slightly attenuate apex and connective with ventral appendages. This study was based on morphological examination of about 2300 specimens from 15 Brazilian herbaria, which found 26 species of the section Miconia in Minas Gerais. We present illustrations, identification key, data on flowering and fruiting, comments, and conservation status for all species of Miconia section Miconia in Minas Gerais.
