RESUMEN
Amyloid goiter (AG) is a condition in which amyloid protein builds up in the thyroid gland. Patients with such a condition tend to have thyroid tissue that is extensively involved by amyloid; however, patients are usually euthyroid. Systemic amyloidosis is one of the conditions that may cause damage to the kidneys or worsen the condition of kidney failure in patients with ongoing chronic kidney disease as amyloid proteins can deposit in a variety of tissues including kidneys. Thyroid goiter can rarely be the first confirmed place to be involved with amyloidosis. We present the case of a 57-year-old female with AG who had a history of renal failure.
RESUMEN
Primary Ewing sarcoma of the kidney (ESK) is a rare and aggressive entity, with a poor prognosis. It often presents as metastatic disease with the lungs being the most common site. In adults, the occurrence of these tumors is uncommon, with patients exhibiting non-specific symptoms such as weight loss, flank pain, hematuria, and an abdominal mass. The combination of these vague clinical symptoms and the rarity of these tumors often results in a delayed diagnosis, leading to poorer outcomes for these patients. We present a case of a 38-year-old female with metastatic ESK. The patient initially presented with abdominal pain, vomiting, and a four-day history of constipation. The diagnosis was confirmed through computed tomography scans, ultrasound-guided biopsy of the lesion, and fluorescence in situ hybridization that revealed translocation of the EWS gene on chromosome 22q12. She was managed with chemotherapy regimens and palliative care; however, the disease progressed and she passed away six months after her initial diagnosis.
RESUMEN
Glioblastoma (GBM) with Primitive Neuroectodermal tumor (PNET) like features is an extremely rare tumor showing dual features of malignant glioma and primitive neuroectodermal tumour occurring mostly in adults. It poses diagnostics dilemma to the neuropathologist and treating oncologist team because of its rarity, tendency to spread to cerebrospinal fluid and dismal prognosis. We have described this tumor in a 11 years old male child in this case report. Keywords: glioma,glioblastoma,primitive neuroectodermal tumor, variant, pediatric.
