Asunto(s)
Grupo Paritario , Profesionalismo , Competencia Clínica , Humanos , Mejoramiento de la CalidadAsunto(s)
Ética Clínica , Salud Global , Juicio , Principios Morales , Toma de Decisiones/ética , Salud Global/ética , Humanos , Juicio/éticaAsunto(s)
Vacunas contra la COVID-19 , COVID-19/prevención & control , Educación en Salud/métodos , Negativa a la Vacunación/psicología , Decepción , Medicina Basada en la Evidencia , Miedo/psicología , Femenino , Humanos , Difusión de la Información , Masculino , Medios de Comunicación Sociales , Estados UnidosRESUMEN
A racemic and scalable enantioselective total synthesis of (+)-waihoensene was accomplished. (+)-Waihoensene belongs to the diterpene natural product family, and it features an angular triquinane substructure motif. Its tetracyclic [6.5.5.5]backbone is all-cis-fused, containing six contiguous stereocenters, four of which are quaternary. These structural features were efficiently installed by means of a diastereoselective radical cyclization, followed by an intramolecular Pauson-Khand reaction, a diastereoselective α-alkylation, and a diastereoselective 1,4-addition reaction. Enantioselectivity was introduced at an early stage, by an asymmetric palladium catalyzed decarboxylative allylation reaction on gram scale.
Asunto(s)
Infecciones por Coronavirus/prevención & control , Promoción de la Salud/métodos , Conductas de Riesgo para la Salud , Máscaras , Pandemias/prevención & control , Neumonía Viral/prevención & control , Ciencia , Confianza , COVID-19 , Economía , Humanos , Relaciones Interpersonales , Autonomía Personal , Política , Clase Social , Estados UnidosRESUMEN
Microcarriers with the ability to release and catch substances are highly desired metamaterials and difficult to obtain. Herein, we report a straightforward strategy to synthesize these materials by combining silica-biomorphs with mesocrystals. An easy access to microcarrier hulls with covalently bound spiropyrans as light-switchable anchor points is presented.