1.
J Enzyme Inhib Med Chem
; 30(2): 216-23, 2015 Apr.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24939099
RESUMEN
The new histone deacylases inhibitors (HDACi) were synthesized in the class of 5-membered cyclic hydroxamic acids (5-CHA), showing medium size CHA as a new Zn-binding group. New reaction sequence was proposed for the synthesis of 5-membered alkylidene-cyclic-hydroxamic acids starting from butyrolactone. Compound 10c showed low µM activity on HeLa cell extracts. From these results, cyclic hydroxamic acids will be further investigated to find more potent compounds.