1.
Org Biomol Chem
; 2024 Aug 06.
Artículo
en Inglés
| MEDLINE
| ID: mdl-39105369
RESUMEN
A novel convenient 2-step synthesis of substituted pyrido[1,2-a]indoles is developed starting from easily available pyrylium tetrafluoroborates and ortho-bromoanilines. A conversion of the pyrylium tetrafluoroborates to pyridinium ones followed by their palladium catalyzed intramolecular cyclization allows the formation of 24 examples of N-fused heterocycles. A one-pot two-stage cyclization procedure was developed. The utility of the methodology was demonstrated with the synthesis of new pyrido[1,2-a]indoles bearing different alkyl, aryl, chlorine, fluorine and methoxy substituents.