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Cell Rep ; 39(1): 110631, 2022 04 05.
Artículo en Inglés | MEDLINE | ID: mdl-35385724

RESUMEN

TOR kinase is a central coordinator of nutrient-dependent growth in eukaryotes. Maintaining optimal TOR signaling is critical for the normal development of organisms. In this study, we describe a negative feedback loop of TOR signaling helping in the adaptability of plants in changing environmental conditions. Using an interdisciplinary approach, we show that the plant-specific zinc finger protein FLZ8 acts as a regulator of TOR signaling in Arabidopsis. In sugar sufficiency, TOR-dependent and -independent histone modifications upregulate the expression of FLZ8. FLZ8 negatively regulates TOR signaling by promoting antagonistic SnRK1α1 signaling and bridging the interaction of SnRK1α1 with RAPTOR1B, a crucial accessory protein of TOR. This negative feedback loop moderates the TOR-growth signaling axis in the favorable condition and helps in the activation of stress signaling in unfavorable conditions, establishing its importance in the adaptability of plants.


Asunto(s)
Proteínas de Arabidopsis , Arabidopsis , Retroalimentación Fisiológica , Transducción de Señal , Serina-Treonina Quinasas TOR , Arabidopsis/metabolismo , Proteínas de Arabidopsis/genética , Proteínas de Arabidopsis/metabolismo , Retroalimentación Fisiológica/fisiología , Proteínas de Plantas/metabolismo , Plantas , Transducción de Señal/fisiología , Serina-Treonina Quinasas TOR/metabolismo
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