1.
J Theor Biol
; 582: 111748, 2024 04 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38336242
RESUMEN
We describe a cell-based fixed-lattice model to simulate immune cell and tumor cell interaction involving MHC recognition, and FasL vs perforin lysis. We are motivated by open questions about the mechanisms behind observed kill rates of tumor cells by different types of effector cells. These mechanisms play a big role in the effectiveness of many cancer immunotherapies. The model is a stochastic cellular automaton on a hexagonal grid.