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1.
Sci Rep ; 14(1): 15390, 2024 07 04.
Artículo en Inglés | MEDLINE | ID: mdl-38965292

RESUMEN

Non-muscle invasive bladder cancers (NMIBC) pTa-pT1 are depicted by a high risk of recurrence and/or progression with an unpredictable clinical evolution. Our aim was to identify, from the original resection specimen, tumors that will progress to better manage patients. We previously showed that A-FABP (Adipocyte- Fatty Acid Binding Protein) loss predicted NMIBC progression. Here we determined by immunohistochemistry the prognostic value of E-FABP (Epidermal-Fatty Acid Binding Protein) expression in 210 tumors (80 pTa, 75 pT1, 55 pT2-T4). Thus, E-FABP low expression was correlated with a high grade/stage, the presence of metastatic lymph nodes, and visceral metastases (p < 0.001). Unlike A-FABP in NMIBC, E-FABP low expression was not associated with RFS or PFS in Kaplan-Meier analysis. But patients of the overall cohort with a high E-FABP expression had a longer mOS (53.8 months vs. 29.3 months, p = 0.029). The immunohistochemical analysis on the same NMIBC tissue sections revealed that when A-FABP is absent, a high E-FABP expression is detected. E-FABP could compensate A-FABP loss. Interestingly, patients, whose original tumor presents both low E-FABP and negative A-FABP, had the worse survival, those maintaining the expression of both markers had better survival. To conclude, the combined evaluation of A- and E-FABP expression allowed to stratify patients with urothelial carcinoma for optimizing treatment and follow-up.


Asunto(s)
Proteínas de Unión a Ácidos Grasos , Neoplasias de la Vejiga Urinaria , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Biomarcadores de Tumor/metabolismo , Proteínas de Unión a Ácidos Grasos/metabolismo , Proteínas de Unión a Ácidos Grasos/genética , Inmunohistoquímica , Estimación de Kaplan-Meier , Pronóstico , Neoplasias de la Vejiga Urinaria/patología , Neoplasias de la Vejiga Urinaria/metabolismo , Neoplasias de la Vejiga Urinaria/mortalidad , Neoplasias de la Vejiga Urinaria/genética
4.
Chest ; 158(5): e229-e232, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-33160542

RESUMEN

CASE PRESENTATION: A 35-year-old man was admitted for recurrent episodes of pneumonia. He complained of a 2-month history of exertional dyspnea and productive cough with whitish and viscous sputum which was poorly responsive to antibiotic therapy. He also reported a weight loss of 5 kg since the first symptoms appeared. There was no dysphagia, fever, or chest pain. He currently did not use medication and did not have a relevant medical history except a current 10 pack-year smoking history. He did not report any history of trauma or respiratory exposure to fats.


Asunto(s)
Quilotórax , Dieta con Restricción de Grasas/métodos , Enfermedades Pulmonares/congénito , Pulmón , Linfangiectasia/congénito , Vasos Linfáticos , Neumonía , Adulto , Biopsia/métodos , Quilotórax/diagnóstico , Quilotórax/etiología , Diagnóstico Diferencial , Humanos , Pulmón/diagnóstico por imagen , Pulmón/patología , Enfermedades Pulmonares/diagnóstico , Enfermedades Pulmonares/dietoterapia , Enfermedades Pulmonares/fisiopatología , Linfangiectasia/diagnóstico , Linfangiectasia/dietoterapia , Linfangiectasia/fisiopatología , Vasos Linfáticos/anomalías , Vasos Linfáticos/diagnóstico por imagen , Linfografía/métodos , Imagen por Resonancia Magnética/métodos , Masculino , Neumonía/diagnóstico , Neumonía/etiología , Recurrencia , Pruebas de Función Respiratoria/métodos , Esputo , Tomografía Computarizada por Rayos X/métodos
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