Exploring the potential of sulphur forms in Northeastern Indian coals: Implications in environmental remediation and heavy metal sensing.

The Sampar Coalfield in Northeastern India is a source of plentiful coal reserves, which are burnt for energy production and industrial applications, resulting in the release of pollutants such as sulphur , arsenic, and lead, which are hazardous to the environment and public health. In this work, samples from the Sampar coalfield have been analyzed to understand the origin, distribution, and various forms of sulphur and their ability to detect toxic heavy metals. The total sulphur concentration ranged from 4.31% to 6%, with organic sulphur being the predominant form at 69.21%, followed by pyritic sulphur at 16.49% and sulphate sulphur at 14.28%. With high sulphur content, this coal indicates a marine influence in the peat-forming swamps. The samples have also been examined for petrographic and elemental analysis, which have revealed the presence of vitrinite, liptinite, inertinite, carbon, hydrogen, nitrogen, oxygen, and mineral matter. In addition, the same coal sample has also been used for electrochemical sensing-based detection of toxic heavy metals like arsenic and lead, and the findings indicate an improved efficacy. These results are expected to have significant implications in the development of effective bio-based remediation strategies in the region to mitigate the harmful effects of coal-related pollution.

Natural sub-bituminous coal as filler enhances mechanical, insulation and flame retardant properties of coir-polypropylene bio-composites.

Additives provide substantial improvement in the properties of composites. Although bio-based composites are preferred over synthetic polymer and metal-based composites, they do not have the requisite properties to meet specific needs. Hence, organic, inorganic and metallic additives are included to improve the properties of bio-based composites. Coal is a readily available resource with high thermal insulation, flame resistance and other properties. This work demonstrates the addition of 20-30% natural sub-bituminous coal as filler for coir-reinforced polypropylene (PP) composites and exhibits an increased tensile strength by 66% and flexural strength by 55% compared to the composites without any filler. Such composites are intended for insulation applications and as a replacement for gypsum-based false ceiling tiles. Various ratios of coal samples were included in the composites and their effect on mechanical, acoustic, thermal insulation, flame and water resistance have been determined. A substantial improvement in both flexural and tensile properties has been observed due to the addition of coal. However, a marginal improvement has been observed in both thermal conductivity (0.65 W/mK) and flame resistance values due to the presence of coal. Adding coal increases the intensity of noise absorption, particularly at a higher frequency, whereas water sorption of the composites tends to decrease with an increase in the coal content. The addition of coal improves and adds unique properties to composites, allowing coir-coal-PP composites to outperform commercially available gypsum-based insulation panels.

Geochemical, mineralogical and toxicological characteristics of coal fly ash and its environmental impacts.

Coal and coal-based products (by-products), along with other fossil fuels should be used with caution because of their impact on human health and the global climate. In the light of the environmental impact these fossil fuels cause, it's essential to understand the elemental configuration of coal-derived samples and their impact on the ecosystem. Some reports in past have described, geochemical and mineralogical physiognomies of fly-ash and their impact on the environment. However, a comprehensive investigation of various aspects of fly ash like geochemistry, mineralogy, morphology, and toxicological effects has been very sparse and the present study reports the above aspects. The ICP-OES studies confirm the presence of various elements (Al, Ca, Fe, Mg, Na, P, S, Si, and Ti) in the samples. The XRD analysis exposed the presence of minerals like Quartz, H-Hematite, Anatase, Muscovite, and Rutile, in addition to the various phases such as amorphous and crystalline in the fly-ash. Specific samples also possessed Ilmenite which is uncommon in many other samples. Chromium and lead, the well-known heavy metals to cause soil and water pollution in the neighbourhood were found to be existing in higher concentrations in the fly-ash samples, whereas cadmium was found to be the least among the toxic elements found in the samples. The samples were subjected to FE-SEM analysis, which reveals the presence of irregularly shaped minerals and unburnt carbon known to reduce the burning efficiency of coal, especially in power plants. Toxicology studies reported in the work suggested that fly-ash is toxic to the environment at higher concentrations than at lower concentrations.

Visible light photodegradation of 2,4-dichlorophenol using nanostructured NaBiS2: Kinetics, cytotoxicity, antimicrobial and electrochemical studies of the photocatalyst.

Removal of the hazardous and endocrine-disrupting 2,4-dichlorophenol (2,4-DCP) from water bodies is crucial to maintain the sanctity of the ecosystem. As a low bandgap material (1.37 eV), NaBiS2 was hydrothermally prepared and used as a potential photocatalyst to degrade 2,4-DCP under visible light irradiation. NaBiS2 appeared to be highly stable and remained structurally undeterred despite thermal variations. With a surface area of 6.69 m2/g, NaBiS2 has enough surface-active sites to adsorb the reactive molecules and exhibit a significant photocatalytic activity. In alkaline pH, the adsorption of 2,4-DCP on NaBiS2 appeared to decrease whereas, the acidic and neutral environments favoured the degradation. An increase in the photocatalyst dosage enhanced the degradation efficiency from 81 to 86 %, because of higher vacant adsorbent sites and the electrostatic attraction between NaBiS2 and 2,4-DCP. The dominant scavengers degraded 2,4-DCP by forming a coordination bond between chlorine's lone pair of electrons and the vacant orbitals of bismuth, following the order hole> OH > singlet oxygen. Being non-toxic to both natural and aquatic systems, NaBiS2 exhibits antifungal properties at higher concentrations. Finally, the electron-rich NaBiS2 is an excellent electrocatalyst that effectively degrades organic pollutants and is a promising material for industrial and environmental applications.

Early-stage culprit in protein misfolding diseases investigated using electrochemical parameters: New insights over peptide-membrane interactions.

The dysfunctioning of ß-cells caused by the unspecific misfolding of the human islet amyloid polypeptide (hIAPP) at the membrane results in type 2 diabetes mellitus. Here, we report for the first time, the early-stage interaction of hIAPP oligomers on the DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) lipid membrane using electrochemical parameters. Electrochemical techniques are better than other techniques to detect hIAPP at significantly lower concentrations. The surface level interactions between the peptide (hIAPP) and lipid membrane (DMPC) were investigated using atomic force microscopy (AFM), confocal microscopy (CM) and electrochemical techniques such as Tafel polarization, cyclic voltammetry (CV), differential pulse voltammetry (DPV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS). Inserting IAPP into the fluid domains results in breaking the lipid-to-lipid interaction, leading to restriction of membrane mobility. The SLateral values of the liposome and IAPP co-solubilized liposome indicates the cooperative insertion of IAPP. Further, a new method of immobilizing a membrane to the gold surface has been employed, resulting in an electrical contact with the buffer, preventing the direct utilization of a steady-state voltage across the bilayer. The electrochemical studies revealed that the charge transfer resistance decreased for 3-mercaptopropanoic acid modified gold (MPA-Au) electrode coated with the liposome and after the addition of IAPP, followed by an increase in the capacitance. The present study has opened up new dimensions to the understanding of peptide-membrane interactions and shows different experimental approaches for the future researchers in this domain.

Optical and Electrochemical Applications of Li-Doped NiO Nanostructures Synthesized via Facile Microwave Technique.

Nanostructured NiO and Li-ion doped NiO have been synthesized via a facile microwave technique and simulated using the first principle method. The effects of microwaves on the morphology of the nanostructures have been studied by Field Emission Spectroscopy. X-ray diffraction studies confirm the nanosize of the particles and favoured orientations along the (111), (200) and (220) planes revealing the cubic structure. The optical band gap decreases from 3.3 eV (pure NiO) to 3.17 eV (NiO doped with 1% Li). Further, computational simulations have been performed to understand the optical behaviour of the synthesized nanoparticles. The optical properties of the doped materials exhibit violet, blue and green emissions, as evaluated using photoluminescence (PL) spectroscopy. In the presence of Li-ions, NiO nanoparticles exhibit enhanced electrical capacities and better cyclability. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) results show that with 1% Li as dopant, there is a marked improvement in the reversibility and the conductance value of NiO. The results are encouraging as the synthesized nanoparticles stand a better chance of being used as an active material for electrochromic, electro-optic and supercapacitor applications.

Highly porous carbon from a natural cellulose fiber as high efficiency sorbent for lead in waste water.

The persistence of hollow centre in the carbon obtained from milkweed floss provides exceptional sorption characteristics, not seen in common biomasses or their derivatives. A considerably high sorption of 320mg of lead per gram of milkweed carbon was achieved without any chemical modification to the biomass. In this research, we have carbonized milkweed floss and used the carbon as a sorbent for lead in waste water. A high surface area of 170m2g-1 and pore volume of 1.07cm3g-1 was seen in the carbon. Almost complete removal (>99% efficiency) of lead could be achieved within 5min when the concentration of lead in the solution was 100ppm, close to that prevailing in industrial waste water. SEM images showed that the carbon was hollow and confocal images confirmed that the sorbate could penetrate inside the hollow tube.

Inhibition of Group IIA Secretory Phospholipase A2 and its Inflammatory Reactions in Mice by Ethanolic Extract of Andrographis paniculata, a Well-known Medicinal Food.

UNLABELLED: Andrographis paniculata Nees is an important medicinal plant found in the tropical regions of the world, which has been traditionally used in Indian and Chinese medicinal systems. It is also used as medicinal food. A. paniculata is found to exhibit anti-inflammatory activities; however, its inhibitory potential on inflammatory Group IIA phospholipases A2 (PLA2) and its associated inflammatory reactions are not clearly understood. The aim of the present study is to evaluate the inhibitory/neutralizing potential of ethanolic extract of A. paniculata on the isolated inflammatory PLA2 (VRV-PL-VIIIa) from Daboii rusellii pulchella (belonging to Group IIA inflammatory secretory PLA2 [sPLA2]) and its associated edema-induced activities in Swiss albino mice. A. paniculata extract dose dependently inhibited the Group IIA sPLA2 enzymatic activity with an IC50 value of 10.3 ± 0.5 µg/ml. Further, the extract dose dependently inhibited the edema formation, when co-injected with enzyme indicating that a strong correlation exists between lipolytic and pro-inflammatory activities of the enzyme. In conclusion, results of this study shows that the ethanolic extract of A. paniculata effectively inhibits Group IIA sPLA2 and its associated inflammatory activities, which substantiate its anti-inflammatory properties. The results of the present study warranted further studies to develop bioactive compound (s) in ethanolic extract of A. paniculata as potent therapeutic agent (s) for inflammatory diseases. SUMMARY: This study emphasis the anti-inflammatory effect of A. paniculata by inhibiting the inflammatory Group IIA sPLA2 and its associated inflammatory activities such as edema. It was found that there is a strong correlation between lipolytic activity and pro-inflammatory activity inhibition. Therefore, the study suggests that the extract processes potent anti-inflammatory agents, which could be developed as a potential therapeutic agent against inflammatory and related diseases.

Molecular dynamics investigation of dipeptide-transition metal salts in aqueous solutions.

Molecular dynamics (MD) simulations of glycylglycine dipeptide with transition metal ions (Mn(2+), Fe(2+), Co(2+), Ni(2+), Cu(2+), and Zn(2+)) in aqueous solutions have been carried out to get an insight into the solvation structure, intermolecular interactions, and salt effects in these systems. The solvation structure and hydrogen bonding were described in terms of radial distribution function (RDF) and spatial distribution function (SDF). The dynamical properties of the solvation structure were also analyzed in terms of diffusion and residence times. The simulation results show the presence of a well-defined first hydration shell around the dipeptide, with water molecules forming hydrogen bonds to the polar groups of the dipeptide. This shell is, however, affected by the strong electric field of divalent metal ions, which at higher ion concentrations lead to the shift in the dipeptide-water RDFs. Higher salt concentrations lead also to increased residence times and slower diffusion rates. In general, smaller ions (Cu(2+), Zn(2+)) demonstrate stronger binding to dipeptide than the larger ones (Fe(2+), Mn(2+)). Simulations do not show any stronger association of peptide molecules indicating their dissolution in water. The above results may be of potential interest to future researchers on these molecular interactions.