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Pak J Pharm Sci ; 31(4): 1285-1291, 2018 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-30033412

RESUMEN

The phytochemical screening, antimicrobial, antioxidant and cytotoxic properties of Camellia sinensis were evaluated in the present study. The phytochemical screening revealed the presence of an applicable amount of lycopene, ß-carotenes, flavonoids and tannins in C. sinensis. Among the phytochemicals, tannin was found to be significantly higher in tea plant. The antimicrobial activity of plant extracts against selected bacterial strains namely, Escherichia coli, Staphylococcus aurous, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, Marginella morganii and Haemophilus influenzae was investigated. The results showed that the stem part of C. sinensis presented greater antimicrobial potential than the leaf and root. Antioxidant activity (assessed through % inhibition of linoleic acid per oxidation test) was the highest (89.22%) in n-hexane extract of root part as compared to other extracts. Finally, the cytotoxicity analysis (haemolytic activity against human erythrocytes) of plant extract showed the negligible (%) lysis of RBCs ranging from 1.73 to 4.01%. In conclusion, it can be suggested that C. sinensis is the potential source to obtain bioactive phenolic compounds with high antimicrobial and antioxidant properties, which could possibly be exploited for the treatment of various infectious diseases.


Asunto(s)
Antiinfecciosos/farmacología , Antioxidantes/farmacología , Camellia sinensis/química , Extractos Vegetales/farmacología , Antiinfecciosos/aislamiento & purificación , Antiinfecciosos/toxicidad , Antioxidantes/aislamiento & purificación , Antioxidantes/toxicidad , Células Cultivadas , Eritrocitos/efectos de los fármacos , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Hemólisis/efectos de los fármacos , Humanos , Ácido Linoleico/química , Oxidación-Reducción , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/toxicidad , Hojas de la Planta/química , Raíces de Plantas/química , Tallos de la Planta/química , Solventes/química
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