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Neurobiol Aging ; 102: 139-150, 2021 06.
Artículo en Inglés | MEDLINE | ID: mdl-33765427

RESUMEN

Premenopausal bilateral ovariectomy is considered to be one of the risk factors of Alzheimer's disease (AD). However, the underlying mechanisms remain unclear. Here, we aimed to investigate long-term neurological consequences of ovariectomy in a rodent AD model, TG2576 (TG), and wild-type mice (WT) that underwent an ovariectomy or sham-operation, using in vivo MRI biomarkers. An increase in osmoregulation and energy metabolism biomarkers in the hypothalamus, a decrease in white matter integrity, and a decrease in the resting-state functional connectivity was observed in ovariectomized TG mice compared to sham-operated TG mice. In addition, we observed an increase in functional connectivity in ovariectomized WT mice compared to sham-operated WT mice. Furthermore, genotype (TG vs. WT) effects on imaging markers and GFAP immunoreactivity levels were observed, but there was no effect of interaction (Genotype × Surgery) on amyloid-beta-and GFAP immunoreactivity levels. Taken together, our results indicated that both genotype and ovariectomy alters imaging biomarkers associated with AD.


Asunto(s)
Enfermedad de Alzheimer/diagnóstico por imagen , Enfermedad de Alzheimer/psicología , Química Encefálica , Función Ejecutiva , Ovariectomía/efectos adversos , Sustancia Blanca/metabolismo , Sustancia Blanca/fisiopatología , Enfermedad de Alzheimer/etiología , Enfermedad de Alzheimer/genética , Animales , Biomarcadores , Modelos Animales de Enfermedad , Genotipo , Imagen por Resonancia Magnética , Ratones Endogámicos C57BL , Ratones Transgénicos , Placebos , Factores de Riesgo , Factores de Tiempo , Sustancia Blanca/diagnóstico por imagen
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