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Biochemistry ; 59(33): 3019-3025, 2020 08 25.
Artículo en Inglés | MEDLINE | ID: mdl-32794692

RESUMEN

Metal nanoparticles (AgNPs and ZnONPs) were synthesized using a green methodology with the green leaves extract of the Bedu (Ficus palmata) tree as a reducing agent and the support of natural fibers. The synthesized AgNPs and ZnONPs were characterized by several techniques, including ultraviolet-visible spectral analysis, powder X-ray diffraction crystal analysis, scanning electron microscopy, EDAX, transmission electron microscopy, and Fourier transform infrared spectroscopy, which confirmed that the synthesized particles are in the nano range (1-100 nm), i.e., 30 nm for AgNPs with polydispersity and a spherical shape, whereas the average size of synthesized ZnONPs is 34 nm and they seem to exhibit a distorted spherical shape. The results of thermogravimetric analysis confirmed a weight loss of 18.02% for AgNPs under exothermic conditions due to the desorption of water, and ZnONPs show weight loss between 265 and 500 °C. Both synthesized MNPs are highly thermally stable. Anti-inflammatory and anti-diabetic studies of metal NPs have been evaluated. The AgNPs and ZnONPs of F. palmata leaves showed remarkably highly potent activity for respective strains. In vitro anti-diabetic activity was found for inhibition of α-amylases and α-glucosidases by synthesized silver nanoparticles.


Asunto(s)
Antiinflamatorios , Ficus/química , Hipoglucemiantes , Nanopartículas del Metal/química , Extractos Vegetales , Hojas de la Planta/química , Antiinflamatorios/síntesis química , Antiinflamatorios/química , Antiinflamatorios/aislamiento & purificación , Antiinflamatorios/farmacología , Células Cultivadas , Eritrocitos/citología , Eritrocitos/efectos de los fármacos , Inhibidores de Glicósido Hidrolasas/síntesis química , Inhibidores de Glicósido Hidrolasas/química , Inhibidores de Glicósido Hidrolasas/farmacología , Tecnología Química Verde/métodos , Humanos , Hipoglucemiantes/síntesis química , Hipoglucemiantes/química , Hipoglucemiantes/aislamiento & purificación , Hipoglucemiantes/farmacología , Concentración 50 Inhibidora , Extractos Vegetales/química , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/farmacología , Plata/química , Espectroscopía Infrarroja por Transformada de Fourier , Difracción de Rayos X , Zinc/química , alfa-Amilasas/antagonistas & inhibidores , alfa-Glucosidasas/efectos de los fármacos , alfa-Glucosidasas/metabolismo
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