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The potential value of hypervascularity detected with power Doppler ultrasonography (PDU) within equine superficial digital flexor tendon (SDFT) as a prognostic factor of SDFT injury is not clear. The purpose of this study was to test the hypothesis that hypervascularity within SDFT is one of the risk factors for subsequent severe SDFT injury and to evaluate the prognostic value. A prospective cohort study of 97 Thoroughbred racehorses without any clinical signs of SDFT injury was conducted. Six variables of age, body weight, sex, the cross-sectional area of SDFT, PDU signal within SDFT and experience of steeplechase were assessed for the possibility of risk factors of subsequent SDFT injury in follow-up period of 1 year. Multivariable logistic regression analyses were used for assessment of the odds ratios (ORs) and 95â¯% confidence intervals (CIs) of SDFT injury. Multivariable logistic regression analysis revealed that the PDU signal within SDFT was a risk factor for the development of SDFT injury in follow-up period (P = 0.017). The adjusted OR of SDFT injury was significantly higher in PDU positive group than in PDU negative group (OR 3.17, 95â¯% CIs 1.20-8.35). Although further studies are required, these results would be useful for early detection and/or prevention of development for clinical severe SDFT injury.
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Enfermedades de los Caballos , Traumatismos de los Tendones , Ultrasonografía Doppler , Animales , Caballos/lesiones , Masculino , Femenino , Traumatismos de los Tendones/veterinaria , Traumatismos de los Tendones/diagnóstico por imagen , Ultrasonografía Doppler/veterinaria , Pronóstico , Estudios Prospectivos , Enfermedades de los Caballos/diagnóstico por imagen , Factores de Riesgo , Miembro Anterior/diagnóstico por imagen , Miembro Anterior/lesiones , Estudios de CohortesRESUMEN
Intravenous acetaminophen is an integral component of multimodal postoperative pain management. This prospective study aims to assess the efficacy of the repeated administration of intravenous acetaminophen and the impact on postoperative patient satisfaction with postoperative pain management after total knee arthroplasty (TKA). We enrolled 98 patients scheduled for unilateral TKA. Patients were randomly assigned to receive either 1000 mg of intravenous acetaminophen at 6-hour intervals (AAP group) or not to receive intravenous acetaminophen (control group). All patients underwent single-shot femoral nerve block after general anesthesia, as well as intraoperative periarticular infiltration of analgesia prior to implantation. The primary outcome was the postoperative numerical rating scale (NRS) pain score at rest. The NRS score was measured just before the administration of study drugs, immediately after arrival in the ward (time 0), and at 6, 12, 18, 24, and 48 h (time 1 to time 5, respectively) postoperatively. We also evaluated the mean doses of rescue opioid use for 24 h postoperatively. At time 5, the AAP group had significantly improved mean NRS score than controls (3.0 vs. 4.0; P < 0.01). Rescue opioid use was significantly lower in the AAP group for 24 hours compared to controls (0.3 µg vs. 0.9 µg; P < 0.01). Repeated intravenous acetaminophen administration after TKA may provide better analgesia and reduce opioid use.
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Acetaminofén , Artroplastia de Reemplazo de Rodilla , Humanos , Acetaminofén/uso terapéutico , Manejo del Dolor , Artroplastia de Reemplazo de Rodilla/efectos adversos , Analgésicos Opioides/uso terapéutico , Estudios Prospectivos , Dolor Postoperatorio/tratamiento farmacológicoRESUMEN
This paper presents the highlights of joint observations of the inner magnetosphere by the Arase spacecraft, the Van Allen Probes spacecraft, and ground-based experiments integrated into spacecraft programs. The concurrent operation of the two missions in 2017-2019 facilitated the separation of the spatial and temporal structures of dynamic phenomena occurring in the inner magnetosphere. Because the orbital inclination angle of Arase is larger than that of Van Allen Probes, Arase collected observations at higher L -shells up to L â¼ 10 . After March 2017, similar variations in plasma and waves were detected by Van Allen Probes and Arase. We describe plasma wave observations at longitudinally separated locations in space and geomagnetically-conjugate locations in space and on the ground. The results of instrument intercalibrations between the two missions are also presented. Arase continued its normal operation after the scientific operation of Van Allen Probes completed in October 2019. The combined Van Allen Probes (2012-2019) and Arase (2017-present) observations will cover a full solar cycle. This will be the first comprehensive long-term observation of the inner magnetosphere and radiation belts.
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With the advent of the Heliophysics/Geospace System Observatory (H/GSO), a complement of multi-spacecraft missions and ground-based observatories to study the space environment, data retrieval, analysis, and visualization of space physics data can be daunting. The Space Physics Environment Data Analysis System (SPEDAS), a grass-roots software development platform (www.spedas.org), is now officially supported by NASA Heliophysics as part of its data environment infrastructure. It serves more than a dozen space missions and ground observatories and can integrate the full complement of past and upcoming space physics missions with minimal resources, following clear, simple, and well-proven guidelines. Free, modular and configurable to the needs of individual missions, it works in both command-line (ideal for experienced users) and Graphical User Interface (GUI) mode (reducing the learning curve for first-time users). Both options have "crib-sheets," user-command sequences in ASCII format that can facilitate record-and-repeat actions, especially for complex operations and plotting. Crib-sheets enhance scientific interactions, as users can move rapidly and accurately from exchanges of technical information on data processing to efficient discussions regarding data interpretation and science. SPEDAS can readily query and ingest all International Solar Terrestrial Physics (ISTP)-compatible products from the Space Physics Data Facility (SPDF), enabling access to a vast collection of historic and current mission data. The planned incorporation of Heliophysics Application Programmer's Interface (HAPI) standards will facilitate data ingestion from distributed datasets that adhere to these standards. Although SPEDAS is currently Interactive Data Language (IDL)-based (and interfaces to Java-based tools such as Autoplot), efforts are under-way to expand it further to work with python (first as an interface tool and potentially even receiving an under-the-hood replacement). We review the SPEDAS development history, goals, and current implementation. We explain its "modes of use" with examples geared for users and outline its technical implementation and requirements with software developers in mind. We also describe SPEDAS personnel and software management, interfaces with other organizations, resources and support structure available to the community, and future development plans. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11214-018-0576-4) contains supplementary material, which is available to authorized users.
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Auroral substorms, dynamic phenomena that occur in the upper atmosphere at night, are caused by global reconfiguration of the magnetosphere, which releases stored solar wind energy. These storms are characterized by auroral brightening from dusk to midnight, followed by violent motions of distinct auroral arcs that suddenly break up, and the subsequent emergence of diffuse, pulsating auroral patches at dawn. Pulsating aurorae, which are quasiperiodic, blinking patches of light tens to hundreds of kilometres across, appear at altitudes of about 100 kilometres in the high-latitude regions of both hemispheres, and multiple patches often cover the entire sky. This auroral pulsation, with periods of several to tens of seconds, is generated by the intermittent precipitation of energetic electrons (several to tens of kiloelectronvolts) arriving from the magnetosphere and colliding with the atoms and molecules of the upper atmosphere. A possible cause of this precipitation is the interaction between magnetospheric electrons and electromagnetic waves called whistler-mode chorus waves. However, no direct observational evidence of this interaction has been obtained so far. Here we report that energetic electrons are scattered by chorus waves, resulting in their precipitation. Our observations were made in March 2017 with a magnetospheric spacecraft equipped with a high-angular-resolution electron sensor and electromagnetic field instruments. The measured quasiperiodic precipitating electron flux was sufficiently intense to generate a pulsating aurora, which was indeed simultaneously observed by a ground auroral imager.
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A short umbilical cord is associated with adverse pregnancy outcomes. However, there is no universally accepted definition of a short cord. OBJECTIVE: This study aimed to determine the umbilical cord length showing the highest correlation with adverse pregnancy outcomes. MATERIALS AND METHODS: The authors retrospectively analyzed the clinical data of women who attempted vaginal birth in the present institution. Umbilical cord lengths were categorized into three groups: less than the first percentile, from the first percentile to less than the tenth percentile, and others. Maternal and neonatal characteristics previously suggested to affect cord length were evaluated. The main outcome was the rate of cesarean delivery. The authors also evaluated the frequency of operative vaginal delivery, small-for-gestational-age (SGA) births, neonatal intensive care unit (NICU) admission, umbilical artery pH < 7.1, and abnormal bleeding during delivery. RESULTS: Cord lengths of 35 and 45 cm corresponded to the first and tenth percentiles, respectively. A short cord was an indi- cator of unplanned cesarean delivery and small-for-gestational-age births. CONCLUSION: An umbilical cord length of ≤ 45 cm is a clinically useful indicator of adverse pregnancy outcomes.
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Cesárea/estadística & datos numéricos , Sangre Fetal/química , Complicaciones del Trabajo de Parto , Resultado del Embarazo/epidemiología , Cordón Umbilical/patología , Adulto , Femenino , Humanos , Concentración de Iones de Hidrógeno , Recién Nacido , Recién Nacido Pequeño para la Edad Gestacional , Unidades de Cuidado Intensivo Neonatal/estadística & datos numéricos , Japón/epidemiología , Complicaciones del Trabajo de Parto/diagnóstico , Complicaciones del Trabajo de Parto/epidemiología , Complicaciones del Trabajo de Parto/etiología , Tamaño de los Órganos , Embarazo , Estudios Retrospectivos , Estadística como Asunto , Arterias Umbilicales/patologíaRESUMEN
Gastric adenocarcinoma of fundic gland type [chief cell predominant type; (GA-FD-CCP)] is a rare gastric cancer variant arising from non-atrophic mucosa without Helicobacter pylori infection in the upper third portion of the stomach. GA-FD-CCP originates deep in the mucosal layer; hence, endoscopic lesion detection is often difficult at an early stage because of a minimal change in the mucosal surface. Here we present a 66-year-old man with an early stage of GA-FD-CCP showing characteristic endoscopic features. Esophagogastroduodenoscopy demonstrated a flat, slightly reddish area with black pigment dispersion and irregular micro-surface structure at the gastric fornix. The tumor was resected by endoscopic submucosal dissection and was pathologically diagnosed as GA-FD-CCP. Prussian blue staining revealed that the black pigment was a hemosiderin deposition. We reported a rare case of successfully treated GA-FD-CCP with black pigmentation that aided in early lesion detection.
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White matter (WM) impairment and motor deficit after stroke are directly related. However, WM injury mechanisms and their relation to motor disturbances are still poorly understood. In humans, the anterior choroidal artery (AChA) irrigates the internal capsule (IC), and stroke to this region can induce isolated motor impairment. The goal of this study was to analyze whether AChA occlusion can injure the IC in the marmoset monkey. The vascular distribution of the marmoset brain was examined by colored latex perfusion and revealed high resemblance to the human brain anatomy. Next, a new approach to electrocoagulate the AChA was developed and chronic experiments showed infarction compromising the IC on magnetic resonance imaging (MRI) scanning (day 4) and histology (day 11). Behavioral analysis was performed using a neurologic score previously developed and our own scoring method. Marmosets showed a decreased score that was still evident at day 10 after AChA electrocoagulation. We developed a new approach able to induce damage to the marmoset IC that may be useful for the detailed study of WM impairment and behavioral changes after stroke in the nonhuman primate.
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Callithrix , Modelos Animales de Enfermedad , Cápsula Interna , Accidente Cerebrovascular , Animales , Callithrix/anatomía & histología , Arterias Cerebrales/anatomía & histología , Humanos , Cápsula Interna/irrigación sanguínea , Cápsula Interna/patología , Imagen por Resonancia Magnética , Trastornos del Movimiento/fisiopatología , Procedimientos Neuroquirúrgicos , Índice de Severidad de la Enfermedad , Accidente Cerebrovascular/patología , Accidente Cerebrovascular/fisiopatologíaRESUMEN
BACKGROUND: It has not yet been determined whether hepatic arterial infusion (HAI) chemotherapy improves survival in patients with early hepatocellular carcinoma (HCC). We evaluated the effectiveness of HAI with high-concentration cisplatin (DDP-H) for the treatment of HCC by comparing outcomes between patients who received HAI with DDP-H before radical local treatment of early-stage HCC [Japan Integrated Staging (JIS) score 0/1] and patients who did not receive HAI chemotherapy. PATIENTS AND METHODS: Survival was analyzed in 114 patients with early-stage HCC who underwent radical local treatment. The patients were divided into two groups: a HAI group (n = 79) who received DDP-H infusion into the whole liver via the proper hepatic artery, and a non-HAI group (n = 35) who did not receive HAI chemotherapy. RESULTS: The cumulative survival rates at 1, 3, and 5 years were 77.4%, 69.2%, and 55.3% in the non-HAI group and 97.4%, 87.0%, and 84.4% in the HAI group, respectively. Survival time prolonged significantly in the HAI group compared with the non-HAI group (log-rank test: P = 0.023; generalized Wilcoxon test: P = 0.012) Multivariate analysis using the Cox proportional hazards model identified HAI with DDP-H as the most important factor affecting survival. CONCLUSIONS: Whole-liver HAI with DDP-H before radical local treatment can improve the prognosis of patients with early-stage HCC.
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Antineoplásicos/uso terapéutico , Carcinoma Hepatocelular/tratamiento farmacológico , Cisplatino/uso terapéutico , Neoplasias Hepáticas/tratamiento farmacológico , Tasa de Supervivencia , Antineoplásicos/efectos adversos , Carcinoma Hepatocelular/fisiopatología , Cisplatino/efectos adversos , Humanos , Infusiones Intraarteriales , Neoplasias Hepáticas/fisiopatología , Estudios ProspectivosRESUMEN
We present a Brownian dynamics theory with full hydrodynamics (Stokesian dynamics) for a Gaussian polymer chain embedded in a liquid membrane which is surrounded by bulk solvent and walls. The mobility tensors are derived in Fourier space for the two geometries, namely, a free membrane embedded in a bulk fluid, and a membrane sandwiched by the two walls. Within the preaveraging approximation, a new expression for the diffusion coefficient of the polymer is obtained for the free-membrane geometry. We also carry out a Rouse normal mode analysis to obtain the relaxation time and the dynamical structure factor. For large polymer size, both quantities show Zimm-like behavior in the free-membrane case, whereas they are Rouse-like for the sandwiched membrane geometry. We use the scaling argument to discuss the effect of excluded-volume interactions on the polymer relaxation time.
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Proteínas de la Membrana/química , Simulación de Dinámica Molecular , Polímeros/química , Difusión , Hidrodinámica , Proteínas de la Membrana/metabolismo , Tamaño de la Partícula , Polímeros/metabolismo , Solventes/químicaRESUMEN
OBJECTIVES: The purpose of the study was to compare the image generated by a classic panoramic machine equipped with a cadmium telluride sensor capable of digital tomosynthesis and special software with images produced by other popular panoramic X-ray machines using a charge-coupled device and native software for image capture. METHODS: Panoramic images were made using a phantom of a human skull on Planmeca ProMax, Planmeca EC Proline, Kodak 8000 and PC-1000. With the last machine we used the PanoACT® software to adjust the entire arch and to adjust the image in selected regions of interest (ROIs). Ten viewers evaluated the images and provided the viewer data. ANOVA for repeated measures was used to compare the means by pairwise comparisons of means. RESULTS: The image of the entire arch adjusted by the PanoACT® software was statistically superior to the images produced by other machines. The images generated and individually adjusted by PanoACT® were statistically superior to all other images. CONCLUSIONS: The image generated by the cadmium telluride sensor has great potential and can be processed to create superior images to those taken with other machines. Furthermore, the ROI individual images enhanced by the PanoACT® were superior to the entire arch adjusted by the same software.
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Procesamiento de Imagen Asistido por Computador/métodos , Radiografía Panorámica/instrumentación , Radiografía Panorámica/métodos , Análisis de Varianza , Compuestos de Cadmio , Síndrome de Diente Fisurado/diagnóstico por imagen , Cavidad Pulpar/diagnóstico por imagen , Humanos , Ligamento Periodontal/diagnóstico por imagen , Fantasmas de Imagen , Cráneo/diagnóstico por imagen , Programas Informáticos , Telurio , Tomografía Computarizada por Rayos X , Ápice del Diente/diagnóstico por imagen , Pantallas Intensificadoras de Rayos XRESUMEN
Development is left-right reversed between dextral and sinistral morphs of snails. In sympatry, they share the same gene pool, including polygenes for shell shape. Nevertheless, their shell shapes are not the mirror images of each other. This triggered a debate between hypotheses that argue either for a developmental constraint or for zygotic pleiotropic effects of the polarity gene. We found that dextrals can be wider or narrower than sinistrals depending on the population, contrary to the prediction of invariable deviation under a developmental constraint. If the pleiotropy is solely responsible instead, the mean shape of each morph should change, depending on the frequency of polarity genotype. Our simulations of this mean shape change under zygotic pleiotropy, however, show that the direction of interchiral difference remains the same regardless of genotype frequency. Our results suggest the presence of genetic variation among populations that changes the maternal or zygotic pleiotropic effect of the polarity gene.
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Estructuras Animales/anatomía & histología , Tipificación del Cuerpo/fisiología , Pleiotropía Genética/fisiología , Patrón de Herencia/genética , Caracoles/anatomía & histología , Animales , Pesos y Medidas Corporales , Análisis Multivariante , TailandiaRESUMEN
The correlation between the geometric and electronic structures of Zn-phthalocyanine (ZnPc) and F16ZnPc on Cu(111) were studied by x-ray standing wave and angle-resolved photoemission spectroscopy. We found evidence for a distortion of the planar molecules upon adsorption, with the central Zn atom in the molecule protruding towards the substrate. This modifies the energy levels of both the molecule and the substrate, which appear as interface states. The site-specific geometric and electronic relaxations are an important effect for organic-metal interface energetics.
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The purpose of this study was to measure the bone volume necessary for secondary bone grafting in the alveolar cleft using surgical simulation software based on three-dimensional computed tomography (CT) scan data, to compare this measurement with the actual volume of the bone graft, and to evaluate consistency. The subjects were 13 patients with cleft lip and palate who underwent CT using a cone-beam CT unit (CB-CT) 1 month before surgery, followed by bone grafting with particulate cancellous bone and marrow (PCBM) to close the cleft. The bone volume necessary for grafting was measured based on the CB-CT scan data. Correlation analysis, a test of the population mean between two samples, and Wilcoxon's signed rank test were conducted between these measurements and the actual bone volume (PCBM volume) used for grafting. SPSS was used for statistical analysis, and the level of significance was set below the 5% level. The results showed a significant correlation, with no significant differences between the two in all tests. These results suggest that measuring and preoperatively calculating the bone volume necessary for bone grafting with surgical simulation software using CB-CT scan data is beneficial.
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Alveoloplastia , Trasplante Óseo/métodos , Labio Leporino/diagnóstico por imagen , Fisura del Paladar/diagnóstico por imagen , Simulación por Computador , Planificación de Atención al Paciente , Terapia Asistida por Computador/métodos , Adolescente , Adulto , Proceso Alveolar/anomalías , Proceso Alveolar/diagnóstico por imagen , Proceso Alveolar/cirugía , Trasplante Óseo/diagnóstico por imagen , Cefalometría/instrumentación , Niño , Labio Leporino/cirugía , Fisura del Paladar/cirugía , Tomografía Computarizada de Haz Cónico , Femenino , Lateralidad Funcional , Humanos , Imagenología Tridimensional , Masculino , Recolección de Tejidos y Órganos , Resultado del Tratamiento , Adulto JovenRESUMEN
OBJECTIVES: Patients with left unilateral spatial neglect draw a human face more satisfactorily than other objects. The aim of the present study is to examine the features of face drawings by patients with neglect and to establish their meaning in the diagnosis of neglect. METHODS: Sixty-four right-handed patients with a right hemisphere stroke underwent the conventional test of the Behavioural Inattention Test (BIT) and showed left unilateral spatial neglect in one or more of the subtests. From the "drawing a man or woman" subtest, 64 samples of face drawing, in which both eyes were placed, were obtained. The percentage deviation of the location of the eyes in the face outline was calculated for 46 face drawings without discontinuity of the outline or severe distortion of the construction. The percentage deviation of the location of the eyes was compared among the patients with neglect, right-hemisphere damaged patients without neglect, and healthy control subjects. RESULTS: The patients with neglect placed the eyes with greater leftward deviation in the face outline compared with the other two groups. The percentage deviation of the eyes was, however, not associated with neglect severity scored with the BIT conventional test. Forty-three percent of the patients with neglect located the eyes leftward beyond the normal range obtained from the performance of the healthy subjects, while none of the patients without neglect showed such abnormal leftward deviation. CONCLUSIONS: The leftward deviation of the eyes in the face drawing suggests the presence but not the severity of left unilateral spatial neglect.
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Ojo , Cara , Lateralidad Funcional/fisiología , Reconocimiento Visual de Modelos/fisiología , Trastornos de la Percepción/diagnóstico , Desempeño Psicomotor/fisiología , Anciano , Atención/fisiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas , Trastornos de la Percepción/fisiopatología , Estimulación Luminosa/métodos , Factores Sexuales , Estadísticas no Paramétricas , Campos Visuales/fisiologíaRESUMEN
Using a hydrodynamic theory that incorporates a momentum decay mechanism, we calculate the drag coefficient of a circular liquid domain of finite viscosity moving in a two-dimensional membrane. We derive an analytical expression for the drag coefficient which covers the whole range of domain sizes. Several limiting expressions are discussed. The obtained drag coefficient decreases as the domain viscosity becomes smaller with respect to the outer membrane viscosity. This is because the flow induced in the domain acts to transport the fluid in the surrounding matrix more efficiently.
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Membrana Celular/química , Aire , Lípidos/química , Viscosidad , Agua/químicaRESUMEN
The objective of this study was to develop a new practical method to reconstruct a high-quality panoramic image in which radiographers would be free from the onerous task of correctly locating the patient's jaws within the image layer of the panoramic unit. In addition, dentists would be able to freely select any panoramic plane to be reconstructed after the acquisition of the raw scan data. A high-speed data acquisition device was used with a CdTe (cadmium telluride) semiconductor detector and a sophisticated digital signal-processing technique based on tomosynthesis was developed. The system processes many vertical strip images acquired with the detector and generates a high-resolution and high-contrast image. To apply the tomosynthesis technique to the acquired strip images correctly, the actual movement of the panoramic unit was measured, including the X-ray tube and detector, in a scan using a calibration phantom and the authors generated a shift amount table needed for the shift-and-add tomosynthesis operation. The results of the experiments with a PanoACT-1000 panoramic unit, which was a PC-1000 panoramic unit fitted with a high frame rate semiconductor detector SCAN-300FPC, demonstrated the capability of a tomosynthesis technique which, when applied to the strip images of a dry skull phantom, could change the location and inclination of an imaging plane. This system allowed the extraction of an optimum-quality panoramic image regardless of irregularities in patient positioning. Moreover, the authors could freely reconstruct a fine image of an arbitrary plane with different parameters from those used in the original data acquisition to study fine anatomical details in specific locations.
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Imagenología Tridimensional/métodos , Maxilares/diagnóstico por imagen , Intensificación de Imagen Radiográfica/métodos , Radiografía Panorámica/métodos , Humanos , Fantasmas de Imagen , Semiconductores , Procesamiento de Señales Asistido por ComputadorRESUMEN
Clear cell adenocarcinoma with endobronchial polypoid growth of the lung is extremely rare. A 65-year-old male with hemosputum was found to have an abnormal shadow in the hilum of the left lung. Computed tomography of the chest revealed that a heterogeneous mass occupied the lumen extending outside the upper lobe bronchus of the left lung. By biopsy, the tumor was determined to be adenocarcinoma. The patient underwent left pneumonectomy with mediastinal lymph node dissection. Macroscopically, the tumor showed a polypoid growth along with the bronchial tree. Microscopically, most of the tumor was composed of large clear cells with partial glandular formation, indicating the tumor to be adenocarcinoma Lymph node metastasis was seen in #5 and #12u. The lung cancer was diagnosed as clear cell adenocarcinoma with endobronchial polypoid growth.