RESUMEN
The effect of radioprotectors of different structure on the syntheses of nitric oxide induced by endotoxin in mice was studied. Using ESR-spectroscopy and spin trap techniques, it was shown that compounds of different chemical structure, such as aminothiols, isothiuronium derivatives, thiazolines, indolylalkylamines and others, suppressed the nitric oxide production in a whole body. The analysis of the relevant literature has confirmed the phenomenon described by the authors: radioprotectors show NO-inhibiting activity.
Asunto(s)
Óxido Nítrico/antagonistas & inhibidores , Protectores contra Radiación/farmacología , Animales , Cisteína/farmacología , Interpretación Estadística de Datos , Espectroscopía de Resonancia por Spin del Electrón , Endotoxinas , Hígado/metabolismo , Masculino , Mercaptoetilaminas/farmacología , Ratones , Óxido Nítrico/biosíntesis , Organotiofosfatos/farmacología , Protectores contra Radiación/administración & dosificación , Detección de SpinRESUMEN
Streptomyces producing ionophore antibiotics were searched for in various natural substrata, such as soil, sea water, and coastline sea mud, in many geographical regions. A total of 393 Streptomyces strains were isolated, 308 of which proved to be capable of producing antibiotics; 135 of these contained water-insoluble antibiotically active substances in the mycelium. Studies by radioindication, spectrophotometry, and potentiometry demonstrated that these partially purified hydrophobic antibiotics possessed ionophore properties. Selectivity to monovalent potassium and ammonium cations seems to be a characteristic feature of hydrophobic antibiotics derived from Streptomyces differing them from other bacteria.
