Effectiveness of exergaming in reducing cancer-related fatigue among children with acute lymphoblastic leukemia: a randomized controlled trial.

BACKGROUND: Little is known about the effectiveness of the newly emerging technology of exergaming in reducing Cancer Related Fatigue (CRF). OBJECTIVES: The study's primary aim was to examine the effectiveness of exergaming in reducing CRF; the secondary aims were to improve functional capacity/endurance and promote physical activity (PA) among children with acute lymphoblastic leukemia (ALL). METHODS: In this Randomized Controlled Trial (RCT), 45 children aged 6-14 years were randomly assigned into group-I, n = 22, and group II, n = 23. Group-I played exergaming of moderate intensity for 60 min, twice a week for three weeks. Group II was given an instructional session regarding the benefits of PA with advice to practice PA for 60 min twice a week. CRF, functional capacity/endurance, and PA were measured using the pediatric quality of life multidimensional fatigue scale (Ped-QLMFS), six-minute walk test (6-MWT), and Godin-Shepard Leisure Time Physical Activity Questionnaire (QSLTPAQ) respectively. All measurements were taken thrice; in the first, third, and fifth weeks of intervention. RESULTS: Group-I demonstrated a significant reduction of CRF, and a significant increase of functional capacity/endurance compared to group-II over the five weeks study period. The effect of time × intervention interaction was significant. Based on Cohen's guidelines, CRF and functional capacity/endurance had large effect sizes (η2 = 0.41, p = .00) and (η2 = 0.27, p = .00) respectively. CONCLUSION: The protocol of exergaming used in this RCT effectively reduces CRF and promotes functional capacity/endurance and PA in children with ALL undergoing chemotherapy. It may provide an alternative treatment modality to decrease the healthcare load.Key messagesCancer-related fatigue (CRF) is described as physical exhaustion, sleep disturbance, emotional distress, and cognitive dysfunction.Exergaming reduces CRF and promotes functional capacity/endurance and physical activity in children with acute lymphoblastic leukemia undergoing chemotherapy.Exergaming may provide an alternative treatment modality to decrease the healthcare load.

Cross-cultural adaptation, reliability, and validity of the Arabic version of neck disability index in patients with neck pain.

STUDY DESIGN: Translation and psychometric testing. OBJECTIVE: To adapt the neck disability index (NDI) cross-culturally to Arabic language and to investigate the reliability and validity of the Arabic version of NDI in an Arabic-speaking sample with neck pain. SUMMARY OF BACKGROUND DATA: Although largely used, no previous reports exist on the translation process or the testing of the psychometric properties of the Arabic version of the NDI. METHODS: Cross-cultural adaptation of an outcome questionnaire. The English version of the NDI was translated into Arabic (NDI-Ar) and back-translated according to established guidelines. Sixty-five patients with neck pain completed the NDI -Ar twice during a 1-week period, to assess its test-retest reliability. Further psychometric testing was done by assessing internal consistency, construct validity (factor structure), and responsiveness. RESULTS: The internal consistency value (Cronbach α) for the NDI-Ar was 0.89. The test-retest reliability (intraclass correlation coefficient) was excellent at 0.96 (95% confidence interval from 0.93 to 0.97). There was a significant correlation (r = 0.92, P < 0.05) between the scores obtained from the first administration of the NDI-Ar and the second administration. Factor analysis demonstrated a 2-factor structure, explaining 67.58% of total variance. The analysis of responsiveness was calculated with an unpaired t test after 1 week of treatment and demonstrating a statically significant difference between stable and improved patients (P < 0.05). The Spearman correlation coefficient (rS = 0.81; P = 0.000) revealed strong relation between the change in score in the NDI-Ar and global rating of change. No ceiling or floor effects were detected in the NDI-Ar. CONCLUSION: The Arabic version of the NDI has a 2-factor 10-item structure and is a reliable, valid, and responsive tool that can be used to assess neck pain in Arabic-speaking patients with neck pain. Therefore, it can be recommended for clinical and research purposes.

A systematic review of the effect of low-level laser therapy in the management of breast cancer-related lymphedema.

PURPOSE: The purpose of this study was to review the effect of low-level laser therapy (LLLT) in the management of breast cancer-related lymphedema (BCRL). METHODS: A systematic review of seven databases for clinical trials for LLLT in the management of BCRL published between 1990 and 2011 was performed. RESULTS: A total of eight studies on 230 patients were found. The methodological qualities of the selected studies were assessed with the Physiotherapy Evidence Database scale, and the studies were categorized according to Sackett's levels of evidence. Five studies were graded at evidence level II. Two studies were graded at evidence level III, and the remaining study was graded at evidence level V. CONCLUSIONS: There is moderate to strong evidence for the effectiveness of LLLT for the management of BCRL from five small studies of acceptable methodological quality. A dose of 1-2 J/cm(2) per point applied to several points covering the fibrotic area can reduce limb volume following BCRL. Further well-designed, large-scale studies are required to determine more precisely how effective LLLT may be in BCRL.