Antiviral drug rodopes: evaluation of wound healing activity.

A chemical investigation of plant Rhododendron ungernii revealed that its leaves are rich in phenolic compounds: flavonoids, catechins and leucoanthocyanidins. An ointment for external application containing 5% of crude phenolic compounds from R.ungernii leaves named Rodopes, was developed at the I. Kutatateladze Institute of Pharmacochemistry and approved for treatment of various forms of herpetic disease. Wound healing potential of Rodopes was investigated in an excision wound model in mice. Faster wound closure of excision wounds in Rodopes-treated animals in comparison with untreated controls due to the increased wound contracting ability, wound closure time, and regeneration of tissues at wound site was observed. Treatment with Rodopes in an animal model of wound healing caused the increased infiltration of macrophages, neutrophils, and fibroblasts in the wound bed compared to untreated wounds. Moreover, Rodopes exhibited the ability to accelerate scab rejection and full reepithelization in test wounds with no signs of bacterial contamination and to form smooth soft scars disappearing in just 1-2 days. We suggest that Rodopes ointment can find application in the treatment of wounds which require quick coverage of skin epithelial layers.

[Polymer films of antiviral preparation Rodopes for dental practice].

There was created new medical form of antiviral reparation Rodopes that surpassed previous forms - Rodopes adhesive ointment and Rodopes ointment - and also traditional preparations Zovirax and Interferon with its increased therapeutic effectiveness. Rodopes polymer films are much more comfortable way of clinical usage and can be successfully and widely used in stomatological practice.

[Treatment of recurrent aphthous stomatitis with application of a preparation of a hesperidin 5.0%].

Open randomized 2-year trial has been performed to analyze effectiveness of Unguentum of a hesperidin developed by us for the treatment of recurrent aphthous stomatitis. 80 patients with recurrent aphthous stomatitis in the age from 15 till 60 years from the contingent of the polyclinic of the veterans of Tbilisi were studied. After inclusion of the preparation into the treatment the pain and duration of inflammatory process have been decreased; the complications were not observed. In the group of patients getting treatment with hesperidin, frequency of unsatisfactory outcomes decreased significantly (chi(2)=9,8, p < 0,05). Reduction of relative risk of unsatisfactory outcomes was about 0,8 (95% CI: 0,29-0,86), reduction of absolute risk - 0,33 (95% CI: 0,13-0,52). It may be concluded that application of a preparation may be considered as one of the options for the treatment of recurrent aphthous stomatitis.