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Bioorg Med Chem Lett
; 20(24): 7283-7, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21106451
RESUMEN
Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (K(i)) as well as excellent activity in human whole blood. These studies led to the discovery of highly potent TACE inhibitors with good DMPK profiles.
