RESUMEN
This study delves into the effects of servant leadership on team innovation performance by examining innovation self-efficacy as a mediating factor and team innovation atmosphere as a moderating factor. Utilizing a questionnaire survey of 311 hotel employees, we employed a structural equation model for rigorous data analysis. Our key findings are summarized as follows: (1) Servant leadership positively influences team innovation performance. Specifically, the dimensions of persuasion and guidance within servant leadership emerge as significant predictors of enhanced team innovation. (2) Servant leadership significantly boosts innovation self-efficacy, highlighting its crucial role in fostering a culture of innovation. (3) Innovation self-efficacy emerges as a pivotal mediator between servant leadership and team innovation performance, underscoring its importance in translating leadership behaviours into tangible innovation outcomes. (4) The team innovation atmosphere positively moderates the relationship between innovation self-efficacy and team innovation performance, indicating that a supportive environment can amplify the impact of individuals' self-beliefs on collective innovation. This research offers valuable theoretical and practical insights into harnessing the power of servant leadership to enhance innovation self-efficacy and, ultimately, team innovation performance. Our findings contribute to a richer understanding of how these variables interact and can inform the development of more effective leadership strategies in organizations seeking to foster a culture of innovation.
RESUMEN
Doxorubicin (DOX) is the most clinically important antibiotic in cancer treatment, but its severe cardiotoxicity and other side effects limit its clinical use. Therefore, monitoring DOX concentrations during therapy is essential to improve efficacy and reduce adverse effects. Here, we fabricated a sensitive electrochemical aptasensor for DOX detection. The sensor used gold wire as the working electrode and was modified with reduced graphene oxide (rGO)/gold nanoparticles (AuNPs) to improve the sensitivity. An aptamer was used as the recognition element for the DOX. The 5' end of the aptamer was modified with a thiol group, and thus immobilized to the AuNPs, and the 3' end was modified with methylene blue, which acts as the electron mediator. The combination between the aptamer and DOX would produce a binding-induced conformation, which changes the electron transfer rate, yielding a current change that correlates with the concentration of DOX. The aptasensor exhibited good linearity in the DOX concentration range of 0.3 µM to 6 µM, with a detection limit of 0.1 µM. In addition, the aptasensor was used for DOX detection in real samples and results, and showed good recovery. The proposed electrochemical aptasensor will provide a sensitive, fast, simple, and reliable new platform for detecting DOX.
