[Corrective action of the microwave electromagnetic field on progeny development in rats with impared uteroplacental circulation]. / Eksperimental'noe issledovanie korrigirueshchego deistviia élektromagnitnykh polei detsimetrovogo diapazona voln na razvitie potomstva krys pri narushenii matochno-platsentarnogo krovoobrashcheniia.

The experiment on 71 non-inbred white pregnant rats, 316 fetuses and placentas, 323 first progeny in experimental chronic impairment of uteroplacental circulation in females with pregnancy in the ploid period has found that decimetric waves (DW) in a weak heat dose (40 mW/cm2) prevents hypotrophy and disorders of fetal and placental development. Also, DW accelerate formation of motorsensory reflexes in the progeny in an early neonatal period and normalize their behavioral reactions at a mature age. The findings may serve experimental-theoretical grounds for application of weak heat DW radiation in obstetric practice in various general and regional hemocirculation.

[The corrective action of limontar in metabolic disorders in the mother-fetus system caused by ethanol exposure during pregnancy]. / Issledovanie korrigiruiushchego deistviia limontara pri obmennykh narusheniiakh v sisteme mat'--plod, vyzvannykh vozdeistviem étanola vo vremia beremennosti.

It was established in experiments on nonbred albino rats that injection of limontar (1 mg/kg) in the fetal period of pregnancy in alcoholic intoxication (6 g/kg) leads to weight loss by the female, normalization of the character of behavior and metabolic shifts in the organism, and removal of the symptoms of excitation of the sympathetic link of cardiovascular system regulation. No harmful effect of limontar on the mother-fetus biosystem was detected.

[New possibilities for metabolic protection from hypoxia in pregnant rats and their progeny]. / Novye vozmozhnosti metabolicheskoi zashchity ot gipoksii beremennykh krys i ikh potomstva.

Individual resistance of pregnant rats and the newborns to acute hypoxic hypoxia was studied. It was found that individual resistance of the organism to hypoxia significantly decreases in the last period of pregnancy. A new drug limontar proved to possess the properties of an active antihypoxia agent. Its administration during the last third of pregnancy stimulated the organism's protective-adaptational reactions, increased the resistance of pregnant, rats and the newborns to hypoxia. Limontar significantly improves the mechanometabolic indices of an isolated perfused heart under hypoxic conditions. Analysis of the obtained data suggests that limontar increases energy formation in the myocardium through activation of a more efficient and energetically beneficial path of succinic acid oxidation.

[The corrective properties of glycine in alcoholic intoxication in the fetal period of pregnancy]. / Korrigiruiushchie svoistva glitsina pri alkogol'noi intoksikatsii v plodnyi period beremennosti.

Natural metabolite glycine administered per os to rats in the fetus period of pregnancy in a dose of 1 mg/kg was found to exert a corrective action with respect to the toxic effect of ethanol in the mother-fetus system. Glycine prevents loss in the body weight, normalizes functional state of the nervous system and metabolic disorders in the maternal organism, improve the redox processes in the lymphocytes changed under alcoholization, and protect the fetus both on the metabolic and microstructural levels.

[The protective action of limontar in pregnant animals with acute hypoxic hypoxia]. / Protektornoe deistvie limontara na beremennykh zhivotnykh pri ostroi gipoksicheskoi gipoksii.

A comparative study of individual resistance of rats to acute hypoxic hypoxia was performed. It was shown that individual resistance of the organism to hypoxia significantly decreases in the course of pregnancy. Limontar is shown to be active antihypoxant. Limontar administered during the last third of pregnancy stimulates protective-adaptive reactions in the females, thus increasing their resistance to hypoxia.

[The transplacental transit and action of ceftazidime on the fetus in an experiment on animals at different times of the pregnancy]. / Transplatsentarnyi perekhod i deistvie tseftazidima na plod v éksperimente u zhivotnykh v raznye sroki beremennosti.

The experiments were conducted on pregnant albino rats to study the transplacental transit of ceftazidime (Fortum) to the fetus on days 14 and 21 of pregnancy after a single intramuscular injection of 100 mg/kg. The antibiotic transition was 5.23, and 51.94% on days 14 and 21, respectively. The total toxic and embryotoxic effects of ceftazidime were studied in pregnant albino rats given intramuscular injections of 100 and 500 mg/kg/day on days 9-20 of pregnancy. Ceftazidime was found to have neither negative effects on the maternal body and nor embryotoxic and teratogenic properties.

[The effect of antenatal nicotine exposure on the male germ cells in Wistar rats]. / Vliianie antenatal'nogo vozdeistviia nikotinom na muzhskie polovye kletki krys linii Vistar.

Chemically pure nicotine in dose 0.4, 1.5 and 5.0 mg/kg bw were percutaneously injected into Wistar rats during 1-20 (I) and 1-8 days (II) of pregnancy. The gametotoxic effect of nicotine in two-month males from offspring of the first generation (F1) was observed in disturbance of differentiation dynamics of spermatocytes at the stage of preleptotene and spermatids of the seventh developmental stage. The suggested quantitative analysis of disturbance in the behaviour of the meiotic chromosomes in metaphase I and II and anatelophase I and II has revealed that nicotine introduction in the period of isolation and migration of the primary sex cells into embryo gonads (2nd series) induces an increase in the level of pathological maturation divisions in the male offspring.

[A clinico-experimental study of the tocolytic properties of salbupart in treating threatened abortion]. / Kliniko-éksperimental'noe izuchenie tokoliticheskikh svoistv sal'buparta pri lechenii ugrozhaiushchikh prezhdevremennykh rodov.

Clinical and experimental studies have revealed that salbupart, a beta-mimetic agent, administered in a dose of 0.14 mg/kg (the maximal therapeutic dose) markedly inhibited the spontaneous and oxytocin-induced uterine contractility, caused no embryotoxic or teratogenic effects, and did not influence fetal growth and development. The efficacy of salbupart tocolytic therapy was estimated as 75%. Blood plasma cAMP levels normalized in the pregnant women over the course of therapy. Clinical and experimental results recommend salbupart for pregnancy protecting therapy in cases with threatened spontaneous abortions.

[The use of the perfused rat heart as a model for selecting antihypoxic compounds]. / Nekotorye aspekty ispol'zovaniia perfuziruemogo serdtsa krysy kak modeli dlia otbora antigipoksicheskikh soedinenii.

The test system for selection of antihypoxic compounds was developed and approved on the basis of the model of the perfused rat heart. It was found that the hypoxic state of the moderate degree of severity simulated on the myocardium is optimal for the assessment of the studied antihypoxic compounds. Taking into consideration the fact that at the early stages of hypoxia the electron transport is disordered at the level of the first enzymatic complex of the respiration chain, the protective actions of the agents (menadione and hydroquinone) being able of shunting the respiration chain to bypass the damaged area were studied. It was found that under hypoxia these compounds improve the energy-dependent contractile properties of the myocardium, that is, show up the antihypoxic effects.

[Protective effect of narcotic analgesics on the mother, fetus and offspring in hypoxia]. / Protektivnoe deistvie narkoana'lgetikov na ma't, plod i potomstvo pri gipoksii.

The protective effect of the narcoanalgetics, viadril (hydroxydione sodium succinate) and administered intraperitoneally in doses of 5 and 20 mg/kg was studied in the experiment on 146 pregnant noninbred white rats with simulated hemic hypoxia in the late pregnancy (the 19th day). The aforementioned rats were studied for the composition of the peripheral blood, their weight gain oxidative isoenzymes (LDH), pH and pO2 in the blood. Wilson's technique was used for the assessment of the fetal status. The offspring was studied with regard to the weight increment, the rate of postnatal mortality, behavioral reactions, etc. It was stated that viadril strengthened the resistance of pregnant animals to hypoxia and contributed to the alleviation of late sequela of posthypoxic changes in the fetus and newborn.

[Effect of fenibut and seduxen on fetal development in the second half of pregnancy]. / Issledovanie vliianiia fenibuta i seduksena na razvitie ploda vo vtoroi polovine beremennosti.

In experiments on rats it was found that fenibut (50 mg/kg, 1/20 of LD50) during a single and repeated administration in the fetus period of pregnancy does not exert any negative effect on the maternal organism, the growth and development of the fetus. Seduxen administered in a dose of 50 mg/kg (1/80 of LD50) alone and in combination with fenibut was shown to decrease the female body weight gain and to disturb the fetus development. Following a single administration on the 17th day of pregnancy, the effect was poorly pronounced.

[Analysis of the damaging action of different doses of nicotine on the female germ cells of rat fetuses]. / Analiz povrezhdaiushchego deistviia razlichnykh doz nikotina na zhenskie polovye kletki plodov krys.

The conducted studies have shown the gametotropic dose-dependent nicotine effect revealed both at the light-optic and ultrastructural levels. The revealed disturbances in oocytes may be regarded as a nonspecific response of the sex cells which is observed mainly in damage of the membrane oocyte components and specific (for sex cells) structure, a synaptonemal complex. Disturbances in the somatic ovary cells manifest only with a high nicotine dose.