The effect of education expenditure on air pollution: Evidence from China.

Education expenditure is essential in mitigating air pollution, but the relationship between education expenditure and air pollution lacks in-depth discussion. Utilizing data at the county level in China during 2007-2021, this study estimates the effect of education expenditure from local governments on air pollution. Our findings demonstrate that education expenditure significantly and negatively affects air pollution, which remains robust after addressing endogeneity. The mechanism analysis presents that education expenditure reduces air pollution through the composition, technique, and income effects. The heterogeneity analysis indicates that the impact of education expenditure exhibits marked regional heterogeneity. Specifically, the role of education expenditure is significant in strong regulation, key, eastern, and central regions. By considering interaction terms, we identify the moderating effects of human capital, economic development, infrastructure construction, and public service for education expenditure. The cost-benefit analysis emphasizes that education expenditure improves social welfare. Our findings can inspire local governments to place more emphasis on air quality and public education expenditure.

A new attempt to remove toluene using nickel-iron bimetallic particle electrode reactor.

A new attempt of removing toluene waste gas using a three-dimensional electrode reaction device with nickel-iron bimetallic particle electrode is presented in this paper. The particle electrode was prepared by a simple liquid phase reduction method. Through bimetal modification, the particle electrode mass transfer rate is increased to 1.29 times, and the degradation efficiency of the reactor is increased by nearly 40%, which makes it possible to remove toluene waste gas by other electrochemical methods in addition to plasma method. The removal efficiency of the particle electrode can be stabilized at more than 80% after 5 cycles (50 h). At the same time, the relationship between independent working parameters and dependent variables is analyzed using the central composite design, and the operating parameters are optimized. Based on this study, the removal mechanism and possible degradation pathway of toluene were investigated. This study provides a supplement to the possibility and theoretical basis of new technology application for electrocatalytic oxidation removal of VOCs.

Pollutant removal in an experimental bioretention cell situated in a northern Chinese sponge city.

To assess the viability and effectiveness of bioretention cell in enhancing rainwater resource utilization within sponge cities, this study employs field monitoring, laboratory testing, and statistical analysis to evaluate the water purification capabilities of bioretention cell. Findings indicate a marked purification impact on surface runoff, with removal efficiencies of 59.81% for suspended solids (SS), 39.01% for chemical oxygen demand (COD), 37.53% for ammonia nitrogen (NH3-N), and 30.49% for total phosphorus (TP). The treated water largely complies with rainwater reuse guidelines and tertiary sewage discharge standards. Notably, while previous research in China has emphasized water volume control in sponge city infrastructures, less attention has been given to the qualitative aspects and field-based evaluations. This research not only fills that gap but also offers valuable insights and practical implications for bioretention cell integration into sponge city development. Moreover, the methodology and outcomes of this study serve as a benchmark for future sponge city project assessments, offering guidance to relevant authorities.

Recent progress of particle electrode materials in three-dimensional electrode reactor: synthesis strategy and electrocatalytic applications.

With the complete promotion of a green, low-carbon, safe, and efficient economic system as well as energy system, the promotion of clean governance technology in the field of environmental governance becomes increasingly vital. Because of its low energy consumption, great efficiency, and lack of secondary pollutants, three-dimensional (3D) electrode technology is acknowledged as an environmentally beneficial and sustainable way to managing clean surroundings. The particle electrode is an essential feature of the 3D electrode reactor. This study provides an in-depth examination of the most current advancements in 3D electrode technology. The significance of 3D electrode technology is emphasized, with an emphasis on its use in a variety of sectors. Furthermore, the particle electrode synthesis approach and mechanism are summarized, providing vital insights into the actual implementation of this technology. Furthermore, by a metrological examination of the research literature in this sector, the paper expounds on the potential and obstacles in the development and popularization of future technology.

Prognostic Value of Left Ventricular Longitudinal Function and Myocardial Fibrosis in Patients With Ischemic and Non-Ischemic Dilated Cardiomyopathy Concomitant With Type 2 Diabetes Mellitus: A 3.0 T Cardiac MR Study.

BACKGROUND: Poorly controlled type 2 diabetes mellitus (T2DM) is known to result in left ventricular (LV) dysfunction, myocardial fibrosis, and ischemic/nonischemic dilated cardiomyopathy (ICM/NIDCM). However, less is known about the prognostic value of T2DM on LV longitudinal function and late gadolinium enhancement (LGE) assessed with cardiac MRI in ICM/NIDCM patients. PURPOSE: To measure LV longitudinal function and myocardial scar in ICM/NIDCM patients with T2DM and to determine their prognostic values. STUDY TYPE: Retrospective cohort. POPULATION: Two hundred thirty-five ICM/NIDCM patients (158 with T2DM and 77 without T2DM). FIELD STRENGTH/SEQUENCE: 3T; steady-state free precession cine; phase-sensitive inversion recovery segmented gradient echo LGE sequences. ASSESSMENT: Global peak longitudinal systolic strain rate (GLPSSR) was evaluated to LV longitudinal function with feature tracking. The predictive value of GLPSSR was determined with ROC curve. Glycated hemoglobin (HbA1c) was measured. The primary adverse cardiovascular endpoint was follow up every 3 months. STATISTICAL TESTS: Mann-Whitney U test or student's t-test; Intra and inter-observer variabilities; Kaplan-Meier method; Cox proportional hazards analysis (threshold = 5%). RESULTS: ICM/NIDCM patients with T2DM exhibited significantly lower absolute value of GLPSSR (0.39 ± 0.14 vs. 0.49 ± 0.18) and higher proportion of LGE positive (+) despite similar LV ejection fraction, compared to without T2DM. LV GLPSSR was able to predict primary endpoint (AUC 0.73) and optimal cutoff point was 0.4. ICM/NIDCM patients with T2DM (GLPSSR < 0.4) had more markedly impaired survival. Importantly, this group (GLPSSR < 0.4, HbA1c ≥ 7.8%, or LGE (+)) exhibited the worst survival. In multivariate analysis, GLPSSR, HbA1c, and LGE (+) significantly predicted primary adverse cardiovascular endpoint in overall ICM/NIDCM and ICM/NIDCM patients with T2DM. CONCLUSIONS: T2DM has an additive deleterious effect on LV longitudinal function and myocardial fibrosis in ICM/NIDCM patients. Combining GLPSSR, HbA1c, and LGE could be promising markers in predicting outcomes in ICM/NIDCM patients with T2DM. EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: 5.

Dynamic changes in cardiac morphology, function, and diffuse myocardial fibrosis duration of diabetes in type 1 and type 2 diabetic mice models using 7.0 T CMR and echocardiography.

Background: Diabetes mellitus (DM) is associated with an increased risk of cardiovascular disease (CVD). Hence, early detection of cardiac changes by imaging is crucial to reducing cardiovascular complications. Purpose: Early detection of cardiac changes is crucial to reducing cardiovascular complications. The study aimed to detect the dynamic change in cardiac morphology, function, and diffuse myocardial fibrosis(DMF) associated with T1DM and T2DM mice models. Materials and methods: 4-week-old C57Bl/6J male mice were randomly divided into control (n=30), T1DM (n=30), and T2DM (n=30) groups. A longitudinal study was conducted every 4 weeks using serial 7.0T CMR and echocardiography imaging. Left ventricular ejection fraction (LV EF), tissue tracking parameters, and DMF were measured by cine CMR and extracellular volume fraction (ECV). Global peak circumferential strain (GCPS), peak systolic strain rate (GCPSSR) values were acquired by CMR feature tracking. LV diastolic function parameter (E/E') was acquired by echocardiography. The correlations between the ECV and cardiac function parameters were assessed by Pearson's test. Results: A total of 6 mice were included every 4 weeks in control, T1DM, and T2DM groups for analysis. Compared to control group, an increase was detected in the LV mass and E/E' ratio, while the values of GCPS, GCPSSR decreased mildly in DM. Compared to T2DM group, GCPS and GCPSSR decreased earlier in T1DM(GCPS 12W,P=0.004; GCPSSR 12W,P=0.04). ECV values showed a significant correlation with GCPS and GCPSSR in DM groups. Moreover, ECV values showed a strong positive correlation with E/E'(T1DM,r=0.757,P<0.001;T2DM, r=0.811,P<0.001). Conclusion: The combination of ECV and cardiac mechanical parameters provide imaging biomakers for pathophysiology, early diagnosis of cardiac morphology, function and early intervention in diabetic cardiomyopathy in the future.

How to promote the sustainable development of virtual reality technology for training in construction filed: A tripartite evolutionary game analysis.

In recent years, virtual reality training technology (VRTT) has been considered by many scholars as a new training method instead of traditional training (TT) to reduce unsafe behaviors ascribed to construction workers (CWs) and corporate accident rates. However, in this process, a conflict of interest arises among the government, construction enterprises (CEs), and CWs. Therefore, this study introduces a quantitative research method, the three-party evolutionary game and creatively combining them with the product life cycle (PLC) to solve this problem by analyzing the equilibrium and evolutionarily stable strategies of the system. Finally, collaborative players' decision-making behaviors and their sensitivity to critical factors are examined. This paper will illustrate these in each stage through numerical simulations. The results of the study indicate that the government plays a dominant role in the VRTT introduction stage. When the government gives CEs appropriate subsidies, CEs will eventually realize the importance of VRTT for CWs. Then the government will gradually reduce the amount of the subsidies in this process. In addition, we also find that the continually high cost will lead to negative policies by the government, which requires the active cooperation and attitude change from CEs and CWs. Ultimately, the government, CEs and CWs adopt the best strategy in the evolutionary process to facilitate the promotion, application and sustainability of VRTT in the construction industry.

Revolutionary technology of low-carbon chemical processes.

This perspective depicts a green hydrogen and green electricity-driven low-carbon future for chemical industry, which requires revolutionary technologies from feedstock replacements, catalyst and reactor innovations to integrated intelligent systems.

Degradation of ciprofloxacin by persulfate activated by Fe(III)-doped BiOCl composite photocatalyst.

Fe-BOC-X photocatalyst was successfully prepared by solvothermal method. The photocatalytic activity of Fe-BOC-X was determined by ciprofloxacin (CIP), a typical fluoroquinolone antibiotic. Under sunlight irradiation, all Fe-BOC-X showed better CIP removal performance than original BiOCl. In comparison, the photocatalyst with iron content of 50 wt% (Fe-BOC-3) has excellent structural stability and the best adsorption photodegradation efficiency. The removal rate of CIP (10 mg/L) by Fe-BOC-3 (0.6 g/L) reached 81.4% within 90 min. At the same time, the effects of photocatalyst dosage, pH, persulfate, persulfate concentration, and combinations of different systems (PS, Fe-BOC-3, Vis/PS, Vis/Fe-BOC-3, Fe-BOC-3/PS, and Vis/Fe-BOC-3/PS) on the reaction were systematically discussed. In reactive species trapping experiments, electron spin resonance (ESR) signals revealed that the photogenerated holes (h+), hydroxyl radical (•OH), sulfate radical (•SO4-), and superoxide radical (•O2-) played an important role in CIP degradation; hydroxyl radicals (•OH) and sulfate radicals (•SO4-) play a major role. Various characterization methods have demonstrated that Fe-BOC-X has larger specific surface area and pore volume than original BiOCl. UV-vis DRS indicate that Fe-BOC-X has wider visible light absorption and faster photocarrier transfer and provides abundant surface oxygen absorption sites for effective molecular oxygen activation. Accordingly, a large number of active species were produced and participated in the photocatalytic process, thus effectively promoting the degradation of ciprofloxacin. Based on HPLC-MS analysis, two possible decomposition pathways of CIP were finally proposed. The main degradation pathways of CIP are mainly due to the high electron density of piperazine ring in CIP molecule, which is mainly attacked by various free radicals. The main reactions include piperazine ring opening, decarbonylation, decarboxylation, and fluorine substitution. This study can better open up a new way for the design of visible light driven photocatalyst and provide more ideas for the removal of CIP in water environment.

Case report: An asymptomatic mother with an inborn error of cobalamin metabolism (cblC) detected through high homocysteine levels during prenatal diagnosis.

Background: The most common disorder of the intracellular cobalamin metabolism pathway is the combined methylmalonic acidemia and homocysteinemia, cblC type (cblC). There is a variation in its clinical spectrum ranging from severe neonatal-onset forms that are highly fatal to later-onset forms which are milder. In this study, the first case of an asymptomatic Chinese woman with a defect in congenital cobalamin (cblC type) metabolism at prenatal diagnosis due to elevated homocysteine level is identified. Case presentation: The proband, a male child born to a 29-year-old G1P0 mother, admitted to local hospital with feeding disorder, intellectual disability, seizures, microcephaly, as well as heterophthalmos. The level of the urine methylmalonic was elevated. Equally found were increased blood propionylcarnitine (C3) and propionylcarnitine/free carnitine ratio (C3/C0) and decreased methionine levels. The plasma total homocysteine level was elevated at 101.04 µmol/L (normal < 15 µmol/L). The clinical diagnosis of combined methylmalonic acidemia and homocysteinemia was supported. Four years later, the mother of the boy married again and came to us for prenatal diagnosis exactly 15 weeks after her last menstrual period. Subsequently, there is an increase in the amniotic fluid methylmalonate. The level of the amniotic fluid total homocysteine was marginally high. A considerably elevated amniotic fluid C3 was equally observed. In addition, there is a respective significant increase in the plasma and urine total homocysteine at 31.96 and 39.35 µmol/L. After the sequencing of MMACHC genes, it is found that the boy, a proband carried a homozygous mutation of the MMACHC at c.658_660delAAG. While the boy's mother, she carries two mutations in MMACHC: c.658_660delAAG and c.617G>A. The fetus is a carrier of the MMACHC gene. Following the administration of routine treatment, the mother remained symptom-free in the course of pregnancy, and she gave birth to a healthy boy. Conclusion: Variable and nonspecific symptoms characterized the cblC type of methylmalonic acidemia combined with homocysteinemia. Both biochemical assays and mutation analysis are recommended as crucial complementary techniques.

TIPE2 deficiency prolongs mouse heart allograft survival by facilitating immature DCs-induced Treg generation.

It has been reported that deletion of tumor necrosis factor-α-induced protein-8 like 2 (TNFAIP8L2, TIPE2) facilitates the activation of T-cell receptors. However, the role of TIPE2 in T-cell-mediated acute transplant rejection remains unclear. To illustrate the underlying cellular mechanisms, we transplanted BALB/c hearts into C57BL/6 wild-type (WT) or C57BL/6 mice deficient for TIPE2 (TIPE2-/-) and found that TIPE2-/- recipient mice showed significantly prolonged survival of heart allografts and suppressed maturation of CD11c+ dendritic cells (DCs), which largely abolished the activation and proliferation of alloreactive T cells and their cytotoxic activity. TIPE2-/- DCs increased CD4+CD25+Foxp3+CD127- regulatory T cells (Tregs)generation, likely by inhibiting DCs maturation and CD80 and CD86 expression. Administration of anti-CD25 abolished the allograft survival induced by TIPE2 deficiency. Moreover, TIPE2 deficiency increased IL-10 production in T cells and in recipient serum and allografts. Mechanistic studies revealed that TIPE2-/- restrained the maturation of DCs via inhibition of PI3K/AKT phosphorylation during alloantigen stimulation. Taken together, TIPE2 deficiency in recipient mice inhibited acute rejection by increasing Tregs generated by immature DCs. Thus, TIPE2 could be a therapeutic target for suppressing rejection in organ transplantation.

Progress in Research and Application of Metal-Organic Gels: A Review.

In recent years, metal-organic gels (MOGs) have attracted much attention due to their hierarchical porous structure, large specific surface area, and good surface modifiability. Compared with MOFs, the synthesis conditions of MOGs are gentler and more stable. At present, MOGs are widely used in the fields of catalysis, adsorption, energy storage, electrochromic devices, sensing, analysis, and detection. In this paper, literature metrology and knowledge graph visualization analysis are adopted to analyze and summarize the literature data in the field of MOGs. The visualization maps of the temporal distribution, spatial distribution, authors and institutions' distribution, influence of highly cited literature and journals, keyword clustering, and research trends are helpful to clearly grasp the content and development trend of MOG materials research, point out the future research direction for scholars, and promote the practical application of MOGs. At the same time, the paper reviews the research and application progress of MOGs in recent years by combining keyword clustering, time lines, and emergence maps, and looks forward to their challenges, future development trend, and application prospects.

Research status of volatile organic compound (VOC) removal technology and prospect of new strategies: a review.

As an important component of air pollution, the efficient removal of volatile organic compounds (VOCs) is one of the most important challenges in the world. VOCs are harmful to the environment and human health. This review systematically introduced the main VOC control technologies and research hotspots in recent years, and expanded the description of electrocatalytic oxidation technology and bimetallic catalytic removal technology. Based on a three-dimensional electrode reactor, the theoretical design of a VOC removal control technology using bimetallic three-dimensional particle electrode electrocatalytic oxidation was proposed for the first time. The future research focus of this method was analyzed, and the importance of in-depth exploration of the catalytic performance of particle electrodes and the system reaction mechanism was emphasized. This review provides a new idea for using clean and efficient methods to remove VOCs.

Degradation of ciprofloxacin by a constitutive g-C3N4/BiOCl heterojunction under a persulfate system.

Ciprofloxacin (CIP) is a third-generation quinolone antimicrobial with broad-spectrum antimicrobial activity, and is not fully metabolized in the human body, resulting in more than 70% of CIP being excreted into water as a prodrug. In this study, g-C3N4/BiOCl heterojunction structure composites were prepared to study the degradation effect of ciprofloxacin (CIP) under photocatalytic conditions. The results showed that CIP at 10 mg L-1 was best degraded after 90 min at 0.3 g L-1 g-C3N4/BiOCl-2, pH of 5.8 and PS dosing of 1 mM. The quenching experiments and electron spin resonance spectroscopy (ESR) confirmed that ˙OH, ˙SO4 - and h+ played a major role. After the photocatalytic degradation of this reaction system, the biological toxicity of CIP was effectively controlled. This material is stable and the CIP removal rate remained above 80% after four cycles of experiments.

Quantification of Early Diffuse Myocardial Fibrosis Through 7.0 T Cardiac Magnetic Resonance T1 Mapping in a Type 1 Diabetic Mellitus Mouse Model.

BACKGROUND: Diffuse myocardial interstitial fibrosis (DMIF) is a key factor for heart failure (HF) in diabetic cardiomyopathy. MRI T1-mapping technique can quantitatively evaluate DMIF. PURPOSE: To evaluate of early DMIF in a type 1 diabetes mellitus (T1DM) mouse model through 7.0 T MRI T1 mapping. STUDY TYPE: Prospective. ANIMAL MODEL: A total of 50 8-week-old C57Bl/6J male mice were divided into control (n = 20) and T1DM (n = 30) groups. FIELD STRENGTH/SEQUENCE: A 7.0 T small animal MRI; gradient echo Look-Locker inversion recovery T1-mapping sequence; cine MRI. Scans were acquired in control and T1DM mice every 4 weeks until 24 weeks. ASSESSMENT: End-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), left ventricle (LV) mass, fractional shortening (FS), and E/A ratio. They were evaluated through echocardiography and cine MRI. The extracellular volume fraction (ECV) was calculated. Sirius Red staining was performed and calculated collagen volume fraction (CVF). STATISTICAL TESTS: Differences in ECV and CVF between two groups were analyzed using one-way analysis of variance. The correlation between ECV and CVF was assessed using Pearson's correlations. RESULTS: Compared with the control group, a progressive decrease in FS, EF, and E/A ratio was observed in the T1DM group. Both ECV and CVF values gradually increased during diabetes progression. A significant increase in ECV and CVF values was observed at 12 weeks (ECV: 32.5% ± 1.6% vs. 28.1% ± 1.8%; CVF: 6.9% ± 1.8% vs. 3.3% ± 1.1%). ECV showed a strong correlation with CVF (r = 0.856). DATA CONCLUSION: ECV is an accurate and feasible imaging marker that can be used to quantitatively assess DMIF changes over time in T1DM mice. ECV has potential to accurately detect DMIF in the early stage and may be a useful imaging tool to assess the need for early intervention in T1DM mice. EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 3.

Synergistic and efficient degradation of acid red 73 by UV/O3/PDS: Kinetic studies, free radical contributions and degradation pathways.

Acid red 73 (AR73) is a representative dye pollutant that poses a threat to the environment and human health. Effectively removing this type of pollutant by conventional processes is difficult. However, this study found that compared with UV/PDS, UV/O3, and PDS/O3, UV/O3/PDS composite system had the highest degradation effect on AR73. The degradation efficiency in the composite system reached 97.61% within 30 min, and the synergistic coefficients in the composite system were all greater than 1. In the UV/O3/PDS system, ·OH was the main free radical that mainly degrades AR73. The increase of PDS dosage promoted the degradation of AR73, but the increase of O3 dosage was difficult to greatly improve the degradation of AR73 effect. The kinetic model of the apparent reaction rate was determined. The UV/O3/PDS system can efficiently degrade AR73 in a wide range of substrate concentrations and pH levels, and at the same time showed good adaptability to various concentrations of anions (Cl-, CO32-, SO32-, and C2O42-). Under raw water quality, the degradation effect of AR73 was still as high as approximately 90%. The theoretical attack site was obtained by DFT calculation, and the possible degradation pathway of AR73 was proposed based on the GC-MS spectrum and UV-Vis absorption spectrum. The attack of -NN- by ·OH, SO4-, and O3 was proposed to be the main possible degradation pathway for AR73. Therefore, this study further improves the understanding of the UV/O3/PDS system and shows the potential applicability of this system in the treatment of dye wastewater.

Mechanism and efficiency of photocatalytic triclosan degradation by TiO2/BiFeO3 nanomaterials.

Hierarchical porous TiO2 photocatalytic nanomaterials were fabricated by impregnation and calcination using a peanut shell biotemplate, and TiO2/BiFeO3 composite nanomaterials with different doping amounts were fabricated using hydrothermal synthesis. The micromorphology, structure, element composition and valence state of the photocatalyst were analyzed using a series of characterization methods, including X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), BET surface area (BET), X-ray photoelectron spectroscopy (XPS), UV-visible diffuse reflectance (UV-vis), fluorescence spectroscopy (PL) and other technological means. Finally, the degradation mechanism and efficiency of BiFeO3 composite photocatalyst on the target pollutant triclosan were analyzed using a xenon lamp to simulate sunlight. The results showed that TiO2/BiFeO3 catalyst fabricated using a peanut shell biotemplate has a specific surface area of 153.64 m2/g, a band gap of 1.92 eV, and forms heterostructures. The optimum doping amount of TiO2/BiFeO3 catalyst was 1 mol/mol, and the degradation rate was 81.2%. The main active substances degraded were ·O2-and ·OH. The degradation process measured is consistent with the pseudo-first-order kinetic model.

Comparison of disinfection by-products formed by preoxidation of sulfamethazine by K2FeO4 and O3 and the influence on cytotoxicity and biological toxicity.

This study researched the formation of disinfection by-products (DBPs) in sulfamethazine (SMZ) chlorination after preoxidation by K2FeO4 and O3 and the influence of preoxidation on cytotoxicity and biological toxicity. Then, the study emphatically analyzed the influencing factors such as NaClO dosage, pH value, reaction temperature, fulvic acid (FA), and bromide and iodide ions. The results showed that preoxidation by K2FeO4 effectively inhibited the formation of DBPs of haloketones (HKS) and trihalomethanes (THMs), with an average inhibition rate of over 60%. The formation of DBPs after preoxidation by O3 was higher than that by K2FeO4; preoxidation by K2FeO4 reduced the influence of NaClO dosage, temperature, and pH value on the production of DBPs after SMZ chlorination. The cytotoxicity and biological toxicity of SMZ chlorination after preoxidation were evaluated and compared by calculating the LC50 value of DBPs and the luminescent bacteria method. The results of both calculation methods showed that the toxicity of DBPs after preoxidation by K2FeO4 was lower than that by O3 preoxidation. K2FeO4 and O3 preoxidation improved the SMZ removal efficiency by 8.41 and 10.49%, respectively, and inhibited the formation of most DBPs, but the preoxidation promoted the formation of highly toxic DBPs (HANs). The toxicity of DBPs formed in SMZ chlorination after preoxidation by K2FeO4 and O3 was slightly higher than that of chlorination disinfection alone, but it was still within the safe range. This study provides more new details about the formation and toxicity changes of DBPs in the process of SMZ chlorination after preoxidation.

Immunotherapy for EGFR-mutant advanced non-small-cell lung cancer: Current status, possible mechanisms and application prospects.

Immune checkpoint inhibitors (ICIs) are effective against advanced and even perioperative non-small-cell lung cancer (NSCLC) and result in durable clinical benefit, regardless of programmed death ligand-1 (PD-L1) expression status in cancer. Existing clinical evidence shows that the effect of immunotherapy in patients with EGFR-mutant NSCLC after the development of tyrosine kinase inhibitor (TKI) resistance is not satisfactory. However, compared with monotherapy, ICIs combined with chemotherapy can improve the efficacy. Encouragingly, compared with that of patients with sensitive mutations, the progression-free survival of patients with rare mutations who were treated with ICIs was increased. Adequately maximizing the efficacy of ICIs in EGFR-mutant NSCLC patients is worth exploring. In this review, we described preclinical and clinical studies of ICIs or combined therapy for EGFR-mutant NSCLC. We further focused on EGFR mutations and the cancer immune response, with particular attention given to the role of EGFR activation in the cancer-immunity cycle. The mechanisms for the natural resistance to ICIs were explored to identify corresponding countermeasures that made more EGFR-mutant NSCLC patients benefit from ICIs.

The Dynamic Characteristics of Myocardial Contractility and Extracellular Volume in Type 2 Diabetes Mellitus Mice Investigated by 7.0T Cardiac Magnetic Resonance.

Type 2 diabetes mellitus (T2DM) is associated with a high prevalence of diastolic dysfunction and congestive heart failure. A potential contributing factor is the accelerated accumulation of diffuse myocardial fibrosis and stiffness. Novel cardiac magnetic resonance (CMR) imaging techniques can identify both myocardial fibrosis and contractility quantitatively. This study aimed to investigate the dynamic characteristics of the myocardial strain and altered extracellular volume (ECV) fraction as determined by 7.0 T CMR in T2DM mice. C57Bl/6J mice were randomly divided into T2DM (fed a high-fat diet) and control (fed a normal diet) groups. They were scanned on 7.0 T MRI every 4 weeks until the end of week 24. The CMR protocol included multi-slice cine imaging to assess left ventricle strain and strain rate, and pre- and post-contrast T1 mapping images to quantify ECV. The ECV in the T2DM mice was significantly higher (p < 0.05) than that in the control group since week 12 with significantly impaired myocardial strain (p < 0.05). A significant linear correlation was established between myocardial strain and ECV (p < 0.001) and left ventricular-ejection fraction and ECV (p = 0.003). The results suggested that CMR feature tracking-derived myocardial strain analysis can assess functional abnormalities that may be associated with ECM alterations in diabetic cardiomyopathy, contributing to the study of diabetic therapy effects.